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slatkin_impl.c
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slatkin_impl.c
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#include <stdio.h>
#include <math.h>
#include <stddef.h>
#include <stdlib.h>
#include <time.h>
#include <limits.h>
/*
#include <omp.h>
*/
#include "slatkin_impl.h"
#include "mersenne.h"
static int seed;
/* Main External API */
void montecarlo(int maxreps, int** counts, int numalleles, double* probability, double* theta_estimate) {
slatkin_result results;
int r_obs[numalleles + 2]; /* slatkin's code expects zeros on both ends of the counts array */
int i;
r_obs[0] = 0;
for(i = 1; i <= numalleles; i++) {
r_obs[i] = counts[i-1];
}
r_obs[numalleles + 1] = 0;
/*
printf("Configuration entered on command line: ");
for (i = 0; i <= numalleles + 1; i++) {
printf(" %i ", r_obs[i]);
}
printf("\n");
*/
results = slatkin_mc(maxreps, r_obs);
/* printf("prob: %f theta: %f\n", results.probability, results.theta_estimate); */
*probability = results.probability;
*theta_estimate = results.theta_estimate;
}
// used by the original main() program for montecarlo.c
slatkin_result slatkin_mc(int maxreps, int r_obs[]) {
slatkin_result results;
double theta_estimate;
int i, j, k, n, repno, Ecount, Fcount;
int *r_random, *r_random_to_free;
double E_obs, F_obs;
double *ranvec;
seedMT(time(NULL));
/* Find k and n from the observed configuration */
k = 0;
n = 0;
while (r_obs[k+1]) {
k++;
n+=r_obs[k];
}
/*
memory management notes - the following are dynamically allocated and need to be freed:
Slatkin allocates these in the ivector, vector, and matrix methods, BUT does not pass back
the raw pointer to the allocated region or "head." Instead, he passes back the spot where he wants
the calling code to write data (in the case of the vector call especially). So...we have to readjust
the pointers *back* in order to free them...wacky, but true.
r_random -- what's being returned is head + 1, so free r_random - 1
ranvec -- just free this pointer
b -- have to walk K+1 rows, free each of the rows, then free b
*/
r_random = ivector(0, k+1);
r_random_to_free = r_random - 1;
r_random[0] = r_random[k+1] = 0;
ranvec = vector(1, k-1); // to avoid doing this in each replicate
/* fill b matrix */
//double **b = matrix(1, k, 1, n);
double **b = create2DDoubleArray(k+1, n+1);
for (j=1; j<=n; j++)
b[1][j] = 1.0 / j;
for (i=2; i<=k; i++) {
b[i][i] = 1.0;
for (j=i; j<n; j++)
b[i][j+1] = (i * b[i-1][j] + j * b[i][j]) / (j + 1.0);
}
F_obs = F(k, n, r_obs);
E_obs = ewens_stat(r_obs);
/*printf("\nn = %d, k = %d, theta = %g, F = %g, maxrep = %d\n",
n, k, theta_est(k, n), F_obs, maxrep);*/
Ecount = 0;
Fcount = 0;
for (repno=1; repno<=maxreps; repno++) {
generate(k, n, r_random, ranvec, b);
if (ewens_stat(r_random) <= E_obs)
Ecount++;
if (F(k, n, r_random) <= F_obs)
Fcount++;
}
theta_estimate = theta_est(k, n);
results.probability = (double) Ecount / (double) maxreps;
results.theta_estimate = theta_estimate;
/* free the dynamically allocated memory - the matrix b is still problematic */
free(ranvec);
free(r_random_to_free);
/*
the allocations occur in the matrix() function, starting on line 207
The matrix first allocates a number of rows (k) as pointers to doubles.
then it allocates all the columns (n) as pointers to doubles.
So to unwind this, we need to walk the matrix and free each row of doubles, and then we
can free the original list of double* pointers to the rows themselves.
right?
*/
for(i=0; i < k+1; i++) {
free(b[i]);
}
free(b);
return results;
}
/* Internal Methods */
void generate(int k, int n, int *r, double *ranvec, double **b) {
double unif(), cum;
int i, l, nleft;
for (i=1; i<=k-1; i++)
ranvec[i] = unif();
nleft = n;
for (l=1; l<k; l++) {
cum = 0.0;
for (i=1; i<=nleft; i++) {
cum += b[k-l][nleft-i] / (i * b[k-l+1][nleft]);
if (cum >= ranvec[l]) break;
}
r[l] = i;
nleft -= i;
}
r[k] = nleft;
}
void print_config(int k, int *r) {
int i;
printf("(");
for (i=1; i<k; i++)
printf("%d,", r[i]);
printf("%d)", r[k]);
printf("\n");
}
double ewens_stat(int *r) {
int *ipt;
double coef;
coef = 1.0;
for (ipt=r+1; *ipt; ipt++)
coef *= *ipt;
return 1.0 / coef;
}
double F(int k, int n, int *r) {
int i;
double sum;
sum = 0.0;
for (i=1; i<=k; i++) sum += r[i] * r[i];
return sum / (n * n);
}
double theta_est(int k_obs, int n) {
/* Estimates theta = 4N*mu using formula 9.26 in Ewens' book */
double kval(double theta, int n);
double xlow, xhigh, xmid;
double eps;
eps = 0.00001;
xlow = 0.1;
while (kval(xlow, n) > k_obs)
xlow /= 10.0;
xhigh = 10.0;
while (kval(xhigh, n) < k_obs)
xhigh *= 10.0;
while ((xhigh - xlow) > eps) {
xmid = (xhigh + xlow) / 2.0;
if (kval(xmid, n) > k_obs)
xhigh = xmid;
else
xlow = xmid;
}
return xmid;
} /* end, theta_est */
double kval(double x, int n) {
int i;
double sum;
sum = 0.0;
for (i=0; i<n; i++)
sum += x / (i + x);
return sum;
}
double** create2DDoubleArray(int rows, int cols) {
double **array;
int i;
array = (double**) malloc(rows * sizeof(double*));
for(i=0; i < rows; i++) {
array[i] = (double*) malloc(cols * sizeof(double));
}
return array;
}
/* DEPRECATED
double **matrix(long nrl, long nrh, long ncl, long nch)
// allocate a double matrix with subscript range m[nrl..nrh][ncl..nch]
{
long i, nrow=nrh-nrl+1,ncol=nch-ncl+1;
double **m;
void nrerror(char error_text[]);
// allocate pointers to rows
m=(double **) malloc((size_t)((nrow+NR_END)*sizeof(double*)));
if (!m) nrerror("allocation failure 1 in matrix()");
m += NR_END;
m -= nrl;
// allocate rows and set pointers to them
m[nrl]=(double *) malloc((size_t)((nrow*ncol+NR_END)*sizeof(double)));
if (!m[nrl]) nrerror("allocation failure 2 in matrix()");
m[nrl] += NR_END;
m[nrl] -= ncl;
for(i=nrl+1;i<=nrh;i++) m[i]=m[i-1]+ncol;
// return pointer to array of pointers to rows
return m;
} */
double *vector(long nl, long nh)
/* allocate a double vector with subscript range v[nl..nh] */
{
double *v;
void nrerror(char error_text[]);
v=(double *)malloc((size_t) ((nh-nl+1+NR_END)*sizeof(double)));
if (!v) nrerror("allocation failure in vector()");
return v-nl+NR_END;
}
int *ivector(long nl, long nh)
/* allocate an int vector with subscript range v[nl..nh] */
{
int *v;
void nrerror(char error_text[]);
v=(int *)malloc((size_t) ((nh-nl+1+NR_END)*sizeof(int)));
if (!v) nrerror("allocation failure in ivector()");
return v-nl+NR_END;
}
void nrerror(char error_text[])
{
fprintf(stderr,"Run-time error...\n");
fprintf(stderr,"%s\n",error_text);
fprintf(stderr,"...now exiting to system...\n");
exit(1);
}
void gsrand(s)
int s;
{
seed = s;
}
double unif() /* REIMPLEMENTED to use Mersenne twister as the PRNG */
{
//int grand();
//return ((double) grand() / RM);
return ((double) randomMT() / UINT_MAX);
}
int grand()
{
int test;
test = A * (seed % Q) - R * (seed / Q);
if (test > 0) seed = test;
else seed = test + M;
return(seed);
}