topics

• Absorption models
  • Sequential Zero-/first-order absorption
  • Parallel zero-/first-order absorption
  • Time-varying KA
  • Transit model with estimated compartment number
• Infusion
  • Modeling rate and duration
• Population modeling
  • Mixture models
  • simeta example
  • Inter-occasion variability
  • Simulate from bootstrap parameter estimates
• Error models
  • Sigma-Like THETA
• Data sets
  • Input data sets
• Application
  • Simulating large time-to-event trials
  • Sobol sensitivity analysis - with sensobol package
  • Sobol sensitivity analysis - with sensitivity package
  • Local sensitivity analysis - with mrgsim.sa
  • Graphical sensitivity analysis - with mrgsim.sa
  • Parallel simulation
  • Estimate parameters for two endpoints
• Adaptive dosing examples
  • Simple adaptive dosing