Sterope is a python3 package that implement a method based on the Dynamic Influence Network (https://www.ncbi.nlm.nih.gov/pubmed/28866584) to analyze the sensitivity of parameter values in the response of a Rule-Based Model written in kappa (https://kappalanguage.org/)
The plan to add methods into Pleiades (https://github.com/glucksfall/pleiades) includes a parameterization employing a Particle Swarm Optimization protocol and other analysis methods that are typical of frameworks like Ordinary Differential Equations. You could write us if you wish to add methods into pleione or aid in the development of them.