Drug side effects in children were mined from openFDA, the publicly available repository of the FDA. This is the first resource of 460,837 adverse drug events (ADEs) with estimated risk across child development stages.
This R shinydashboard application is the publically accessible web application of our resource.
The goal of the Pediatric Drug Safety portal (PDSportal) is to access our generated database to easily identify and evaluate evidence for adverse drug events in the pediatric population.
You can download this (unzip first) and place it in the data/ folder to use the app locally:
https://pds-database.s3.amazonaws.com/effect_peds_19q2_v0.3_20211119.sqlite.gz
Giangreco, Nicholas P. and Tatonetti, Nicholas P., A Database of Pediatric Drug Effects to Evaluate Ontogenic Mechanisms From Child Growth and Development. Available at SSRN: https://ssrn.com/abstract=3898786 or http://dx.doi.org/10.2139/ssrn.3898786
Giangreco, N.P., Tatonetti, N.P. Evaluating risk detection methods to uncover ontogenic-mediated adverse drug effect mechanisms in children. BioData Mining 14, 34 (2021). https://doi.org/10.1186/s13040-021-00264-9.