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Code for simulation and figure plotting for "Loss or Gain of Function? Effects of Ion Channel Mutations on Neuronal Firing Depend on the Neuron Type" by Koch et al. 2023. Modelling on the effects of ion current property changes on firing behaviour in diverse neuronal models and in with episodic ataxia type 1 associated KCNA1 mutations.

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Koch et al. 2023 Code Repository

Code for simulation and figure plotting for "Loss or Gain of Function? Effects of Ion Channel Mutations on Neuronal Firing Depend on the Neuron Type" by Koch et al. 2023. https://doi.org/10.3389/fneur.2023.1194811 Modelling on the effects of ion current property changes on firing behaviour in diverse neuronal models and in with episodic ataxia type 1 associated KCNA1 mutations.

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  1. ./Code Python code for simulations and analysis.

    • ./Code/run_simulations.sh Bash shell script to run all simulations and analysis
    • ./Code/Functions All functions for all neuronal models
    • ./Code/Neuron_models Scripts to run each neuronal models
    • ./Code/Sensitivity_Analysis Scripts to run sensitivity analysis for each neuronal models
    • ./Code/KCNA1_mutations Scripts to simulate all KCNA1 mutations in each neuronal models
    • ./Code/csv_generation Scripts for additionaly analysis and to make .csv files needed for plottting
  2. ./Figures Figures and python files for generating them

    • ./Figures/Data Data used to plot figures

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Code for simulation and figure plotting for "Loss or Gain of Function? Effects of Ion Channel Mutations on Neuronal Firing Depend on the Neuron Type" by Koch et al. 2023. Modelling on the effects of ion current property changes on firing behaviour in diverse neuronal models and in with episodic ataxia type 1 associated KCNA1 mutations.

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