* Correspondence: Nan Liu (liu.nan AT duke-nus.edu.sg)
If you are conducting research on HRnV, please cite the following article (methodology with clinical application):
Liu N, Guo DG, Koh ZX, Ho AFW, Xie F, Tagami T, Sakamoto JT, Pek PP, Chakraborty B, Lim SH, Tan JWC, Ong MEH. Heart rate n-variability (HRnV) with its application to risk stratification of chest pain patients in the emergency department. BMC Cardiovascular Disorders 2020; 20: 168. https://doi.org/10.1186/s12872-020-01455-8
If you are using the "HRnV-Calc" software (HRnV-Calc is developed based on the PhysioNet Cardiovascular Signal Toolbox), please also cite the following articles:
Vest A, Da Poian G, Li Q, Liu C, Nemati S, Shah A, Clifford GD. An Open Source Benchmarked Toolbox for Cardiovascular Waveform and Interval Analysis. Physiological Measurement 39, no. 10 (2018): 105004. https://doi.org/10.5281/zenodo.1243111; 2018.
Niu C, Guo D, Ong MEH, Koh ZX, Marie-Alix GAL, Ho AFW, Lin Z, Liu C, Clifford DG, Liu N. HRnV-Calc: A software for heart rate n-variability and heart rate variability analysis. Journal of Open Source Software 2023; 8(85): 5391. https://doi.org/10.21105/joss.05391
We proposed a novel representation of beat-to-beat variation in ECG, named as heart rate n-variability (HRnV), as an alternative to conventional heart rate variability (HRV). The derivation of HRnV parameters are based on multiple RR interval sequences, with or without overlap. We are able to create many sets of HRnV parameters which are promising at generating supplementary information from limited data source. We believe that HRnV is an important addition to traditional HRV, and will contribute to extending the landscape of current studies.
HRnV-Calc is a software package that calculates both HRnV and conventional HRV parameters. Please refer to the following link for details. https://github.com/nliulab/HRnV-Calc