Interplay between DNA damage repair and apoptosis shapes tumor evolution and clinical outcome through aneuploidy and microsatellite instability

Citation

Noam Auslander, Yuri I Wolf, Eugene V Koonin. Interplay between DNA damage repair and apoptosis shapes cancer evolution through aneuploidy and microsatellite instability. Nature Communications, March 2020.

System requirments

System requirements: MATLAB has to be installed Version checked on: MATLAB 2018a OS tested: mac OS 10.12.6 ans 10.10.5 Typical running time: all codes run in a few minutes or less

Description

This code is divided into three directories, in each is the code for different part of the manuscript. The codes are parted to different scripts, which are performing the analyses and plotting the main figures in the manuscript

STEP 1 - Analyses related to Figure 1

Scripts to run (to reproduce Figure 1 results):

1. FIGURE1A
2. FIGURE1B
3. FIGURE1C
4. FIGURE1D

STEP 2 - Analyses related to Figures 2-3

Scripts to run (to reproduce Figure 2-3 results):

1. FIGURE2A
2. FIGURE2B
3. FIGURE2D
4. FIGURE3AB
5. FIGURE3CD

STEP 3 - Analyses related to Figures 4-5

Scripts to run (to reproduce Figure 4-5 results):

1. FIGURE4A
2. FIGURE4BDE
3. FIGURE4C
4. FIGURE5ABC
5. FIGURE5DE
6. FIGURE5F