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added diagram
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iskandr committed Jun 10, 2019
1 parent db4f0c6 commit 2e96455
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2 changes: 1 addition & 1 deletion README.md
Expand Up @@ -352,7 +352,7 @@ Multiple distinct variant sequences and reference contexts can generate the same

* [IsovarResult](https://github.com/openvax/isovar/blob/master/isovar/isovar_result.py): Since a single variant locus might have reads which assemble into multiple incompatible coding sequences, an `IsovarResult` represents a variant and one or more `ProteinSequence` objects which are associated with it. We typically don't want to deal with *every* possible translation of *every* distinct sequence detected around a variant, so the protein sequences are sorted by their number of supporting fragments and the best protein sequence is made easy to access. The `IsovarResult` object also has many informative properties such `num_alt_fragments`, `fraction_ref_reads`, &c.


![](isovar_design.png)

## Other Isovar Commandline Tools

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3 changes: 1 addition & 2 deletions isovar/protein_sequence_helpers.py
Expand Up @@ -43,8 +43,7 @@ def sort_protein_sequences(protein_sequences):
def group_equivalent_translations(translations):
"""
Convert a list of Translation objects into a (potentially smaller) list
of ProteinSequence objects by grouping the
equivalent amino acid sequences.
of ProteinSequence objects by grouping the equivalent amino acid sequences.
Parameters
----------
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2 changes: 1 addition & 1 deletion isovar/read_collector.py
Expand Up @@ -33,7 +33,7 @@

class ReadCollector(object):
"""
ReadCreator holds options related to extracting reads from SAM/BAM alignment files
ReadCollector holds options related to extracting reads from SAM/BAM alignment files
and provides methods for different ways to create LocusRead objects.
"""
def __init__(
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