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Merge pull request #188 from pharmaverse/187_vignettes_add_bicr@devel
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Closes #187 Update vignettes: add BICR alongside IRF
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bundfussr committed Dec 6, 2022
2 parents 1f65f64 + 30ec37f commit 2fbceba
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13 changes: 7 additions & 6 deletions vignettes/adrs.Rmd
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Expand Up @@ -71,8 +71,8 @@ unless otherwise specified.*
- [Derive Best Overall Response Parameter](#bor)
- [Derive Best Overall Response of CR/PR Parameter](#bcp)
- [Derive Response Parameters requiring Confirmation](#confirm)
- [Derive Parameters using Independent Review Facility (IRF)
responses](#irf)
- [Derive Parameters using Independent Review Facility (IRF)/
Blinded Independent Central Review (BICR) responses](#irf)
- [Derive Death Parameter](#death)
- [Derive Last Disease Assessment Parameters](#lsta)
- [Derive Measurable Disease at Baseline Parameter](#mdis)
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The first step involves company-specific pre-processing of records for
the required input to the downstream parameter functions. Note that this
could be needed multiple times (e.g. once for investigator and once for
Independent Review Facility (IRF) records). It could even involve
merging input data from other sources besides `RS`, such as `ADTR`.
Independent Review Facility (IRF)/Blinded Independent Central Review
(BICR) records). It could even involve merging input data from other
sources besides `RS`, such as `ADTR`.

This step would include any required selection/derivation of `ADT` or
applying any necessary partial date imputations, updating `AVAL` (e.g.
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)
```

## Derive Parameters using Independent Review Facility (IRF) responses {#irf}
## Derive Parameters using Independent Review Facility (IRF)/Blinded Independent Central Review (BICR) responses {#irf}

All of the above steps can be repeated for different sets of records,
such as now using assessments from the Independent Review Facility
such as now using assessments from the IRF/BICR
instead of investigator. For this you would just need to replace the
first steps with selecting the required records, and then feed these as
input to the downstream parameter functions.
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2 changes: 1 addition & 1 deletion vignettes/adtte.Rmd
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Expand Up @@ -164,7 +164,7 @@ response: If using `ADRS` / `ADEVENT` parameters as input for any response dates
to add the response date as a temporary variable (e.g. `TEMP_RESPDT`) to be able to feed
into `admiral::derive_param_tte()` as the start date. You would also need to use this
to filter the input datasets so as to only derive the records for responders.
This could also be repeated as needed for IRF and confirmed responses.
This could also be repeated as needed for IRF/BICR and confirmed responses.

Here is an example of the code needed.

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