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# popgenmethods / defiNETti Public

defiNETti is a program for performing Bayesian inference on exchangeable (or permutation-invariant) data via deep learning. In particular, it is well-suited for population genetic applications.

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# defiNETti

defiNETti is a program for performing Bayesian inference on exchangeable (or permutation-invariant) data via deep learning. In particular, it is well-suited for population genetic applications.

## Installation instructions

Prerequisites:

1. Scientific distribution of Python 2.7 or 3, e.g. [Anaconda](http://continuum.io/downloads), [Enthought Canopy](https://www.enthought.com/products/canopy/)
2. Alternatively, custom installation of pip, the SciPy stack

(Optional) Create a virtual environment to store the dependencies. For python 2:

$pip install virtualenv$ cd my_project_folder
$virtualenv my_project  For python 3: $ python3 -m venv my_project_folder


To activate the virtual environment:

$source my_project/bin/activate  To install, in the top-level directory of defiNETti (where "setup.py" lives), type: $ pip install .


## Simulation

The simulator is a function that returns a single datapoint tuple of (data, label).

1. data - A numpy array (e.g. genotype matrix, images, or point clouds) of 2 or 3 dimensions.
2. label - A numpy array of 1 dimension associated with the particular data array.

### Simulator Example

An example simulator for inferring gaussian parameters:

import numpy as np

def simulator_gaussian():
mu = np.random.beta(5, 10)
sigma = np.random.uniform(6,10)
data = np.random.normal(mu, sigma, (100,1))
label = np.array([mu, sigma])

return (data,label)


A more detailed population genetics-specific example is shown in example/. Note in principle the simulator object could randomly sample from a fixed dataset if no generative model is available.

## Neural Network

The neural network building blocks in this program supports two types of layers:

1. Convolutional Layers - The syntax is written as ('conv', <#width>, <#output depth>). Note that the height of the image patches is assumed to be 1 to enforce exchangeability.
2. Fully-connected Layers - The syntax is written as ('fc', <#nodes>).
3. Matrix Multiply Layers - The last layer of the h_net neural network in the regression task. The syntax is written as ('matmul',).
4. Softmax Layers - The last layer of the h_net neural network in the classification task. The syntax is written as ('softmax',).

For more information regarding the differences see: (http://cs231n.github.io/convolutional-networks/). The multiple layers can be combined in the form of a list with the first element corresponding to the first layer and so on. For example, [("fc",1024),("fc",1024), ('softmax',)].

## Training

The train command trains an exchangeable neural network using simulation-on-the-fly. The exchangeable neural network learns a permutation-invariant function mapping f from the data X = (x_1, x_2, \ldots, x_n) to the label or the posterior over the label \theta. In order to ensure permutation invariance, the function can be decomposed as:

f(X) = (h \circ g)(\Phi(x_1), \Phi(x_2), \ldots , \Phi(x_n))

• \Phi - a function parameterized by a neural network that applies to each row of the input data.
• g - a permutation-invariant function (e.g. max, sort, or moments).
• h - a function parameterized by a neural network that applies to the exchangeable feature representation g(\Phi(x_1), \Phi(x_2), \ldots , \Phi(x_n)).

For regression tasks, the output is an estimate of the label \hat{\theta} = f(X). For classification tasks, the output is a posterior over labels \mathcal{P}_{\theta} = f(X).

### Arguments

• input_shape - A tuple specifying the shape of the data output by <simulator> or X. For example, if the data is a 50 x 50 image, then the shape should be listed as (50,50). Note that we always enforce permutation invariance in the 1st dimension and only support 2 or 3 dimensions.
• output_shape - A tuple specifying the shape of the label output by <simulator> or \theta. For example, if the label is a 5-length continuous vector then the shape should be listed as (5,). If the label is a discrete variable, the size of the dimension is the number of classes. Note that currently only classification of a single label is implemented. Only 1 dimensional labels are currently supported.
• simulator - A function which returns tuples of (data, label) as mentioned above.
• phi_net - A neural network parameterizing \Phi shown above. The input syntax is shown in the Neural Network section above.
• g - An operation parameterizing the permutation-invariant function g as shown above. The supported options include ('max',), ('sort',), ('top_k', <k>), or ('moments', <m1>, <m2>, ...)
• h_net - A neural network parameterizing h as shown above. The input syntax is the same as for phi_net.
• network_function - A function of tensorflow operations specifying the neural net if you want to create your own network (if present ignores phi_net, g, and h_net).
• loss - The loss function to choose to train your neural network. Either "cross-ent" for cross-entropy loss or "l2" for l2-loss or a user-defined tensorflow function.
• accuracy - The metric for measuring accuracy to output. Either "classification" for 0-1 loss accuracy, None for using loss function as accuracy, or a user-defined tensorflow function.
• num_batches - The number of iterations (or batches) of training to perform when training the neural network.
• batch_size - The size of each batch.
• queue_capacity - The number of training examples to hold in the queue at once.
• verbosity - Print every accuracy every <verbosity> iterations.
• training_threads - The number of threads dedicated to training the network.
• sim_threads - The number of threads dedicated to simulating data.
• save_path - The base filename to save the neural network. If None, the weights are not saved.
• training_summary - The filename to save a summary of the training procedure. The format of the file is <batch_count> <loss_value> <accuracy>. If None, then no summary file is created.
• logfile - Log extra training information to logfile. If logfile='.', logs to STDERR.

Note: How to include distances for the 3-dimension use case. Vector can simply be padded with a 1 in the second dimension. Note: How to feed in simulators in python? Note: Return accuracy values for training curves?

## Testing

The test command takes in data and a trained neural network to output predictions.

### Arguments

• data - A list of numpy arrays on which to run the neural network. The dimension of each numpy array should be the same as the input_shape in train().
• model_path - Path to the basename where the network is stored, should be same as save_path in train().
• threads - Number of threads used for the tensorflow operations

### Output

• output - A numpy array containing the network output for each input. The dimensions of the numpy array are (<length of data list>, <output_shape[0]>).

## Population Genetic Example

A population genetics-specific example can be found in example/. Note that msprime version 0.4.0 is needed to run this example. This is a simpler version than the experiments used in the paper version.

### Quick Start

To run the example, (for python 3 use python3 instead of python)

$cd example$ python run_example.py


The expected accuracy after the first few hundred batches should be around ~80-90% with a slow steady increase after that. For 5 threads of simulation and training, the training should take roughly half an hour per 1000 batches. In the paper, we used compute resources that allocated 24 threads for each simulation and training.

• For inference purposes, we recommend running for around 20000 batches or once there is clear convergence.
• The speed of the method is dependent on the number of CPU cores available for simulation. We recommend experimenting with the number of threads dedicated to simulation and training to find the optimal speed. (Make sure it sums to the total number of cores available).
• Distances are normalized to be on the order of 0 and 1 for optimization purposes.
• More SNPs than necessary are simulated then truncated and the hotspot region is centered.
• A prior over rates is generated from the HapMap recombination map. In the paper version, we use windows of the fine-scale recombination map rather than flat rates as in the example.
• When dealing with missing data, it may be helpful to copy the missing-ness patterns for the real data.

defiNETti is a program for performing Bayesian inference on exchangeable (or permutation-invariant) data via deep learning. In particular, it is well-suited for population genetic applications.

v1.0 Latest
Apr 10, 2018

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