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Comparison mode

Salvador Martínez de Bartolomé edited this page Sep 14, 2016 · 2 revisions

Due to different networks are constructed from different data, it is difficult to compare these networks between them, because, for example, in case of protein nodes, one protein node in network 1 can be composed by protein A, protein B and protein C because they share all their peptides, and in network 2, due to the detection of a peptide unique to protein C, we will have protein A and protein B in one single protein node and protein C in another protein node.

These situations are difficult to manage when we want to know which proteins or peptides are in common or different between two networks, and ProteinClusterQuant identify all these nodes as the same, in order to get a rough estimation of the comparison. ProteinClusterQuant comparison mode perform a comparison of different networks created by the analysis mode in order to detect which are the peptide nodes or protein nodes that are in common or are different between these networks. It basically construct a Venn diagram between the networks reporting the overlapping nodes and unique nodes.

Venn diagram as output of the comparison

Input parameters file

A template for this input parameter file can be downloaded here.

# Note: lines starting with '#' are ignored

######################################################
# Comparison type: Compare peptide nodes ('PEPTIDE_NODES') or protein nodes ('PROTEIN_NODES')
######################################################
comparison_type	PROTEIN_NODES

######################################################
# FDR threshold: only consider the entries with a FDR value greater than the threshold
######################################################
threshold	0.05

######################################################
# INPUT FILES TO COMPARE 
# Each file contains two columns, separated by a TAB.
# first column correspond with the name of the dataset
# second column correspond with the full path to the file corresponding to the FDR output file of a PCQ analysis, which typically is named as: 'prefix_FDR_sufix.txt' where prefix and sufix correspond to the input analysis parameters: 'output_prefix' and 'output_sufix'
######################################################
dataset1	/path_to_significance_files/prefix1_FDR_suffix1.txt
dataset2	/path_to_significance_files/prefix2_FDR_suffix2.txt
dataset3	/path_to_significance_files/prefix2_FDR_suffix2.txt

Where:

  • comparison_type indicates if the comparison is going to be performed at protein_node or peptide_node level
  • threshold indicates which portion of the datasets are taken into account in the comparison by defining a minimum FDR threshold.
  • dataset1, dataset2 and dataset3 are arbitrary names assigned to each ones of the datasets to compare. They are separated by a TAB from the path where the output FDR file is located. Note that each dataset is indicated in a different line and that 2 or 3 datasets are allowed to be compared.

Example of output of a comparison between two networks at protein node level:

###############
Comparison made on: Tue Sep 13 17:45:56 PDT 2016
Datasets compared: 
RW	C:\Users\Salva\Desktop\Dropbox\papers\SCRIPPS\Protein Cluster Quant\second submission\Suplemental Networks\SuppNetwork8_FibulinRW_OLD_DB_3PSMsPerPeptide_2016-09-13-15-07-38\FibulinRW_OLD_DB_FDR_3PSMsPerPeptide.txt
WT	C:\Users\Salva\Desktop\Dropbox\papers\SCRIPPS\Protein Cluster Quant\second submission\Suplemental Networks\SuppNetwork9_FibulinWT_OLD_DB_3PSMsPerPeptide_2016-09-13-16-45-25\FibulinWT_OLD_DB_FDR_3PSMsPerPeptide.txt
lacZ	C:\Users\Salva\Desktop\Dropbox\papers\SCRIPPS\Protein Cluster Quant\second submission\Suplemental Networks\SuppNetwork10_FibulinLacZ_OLD_DB_3PSMsPerPeptide_2016-09-13-17-17-11\FibulinLacZ_OLD_DB_FDR_3PSMsPerPeptide.txt

Venn diagram URL (copy and paste the following URL in a browser to get the Venn Diagram): 
http://chart.apis.google.com/chart?chs=500x500&chd=t:85,103,111,37,36,33,26&cht=v&chdl=RW(85)|WT(103)|lacZ(111)&chtt=RW vs WT vs lacZ&chds=0,111&chdlp=b&chma=|10,10

 1 -> RW = 85 (39.2% of union)
 2 -> WT = 103 (47.5% of union)
 3 -> lacZ = 111 (51.2% of union)

Union=217 (100%)
Overlap (1,2) = 37 (24.5% of Union (1,2))
Union (1,2) = 151 (69.6% of Total Union)
Overlap (1,3) = 36 (22.6% of Union (1,3))
Union (1,3) = 159 (73.3% of Total Union)
Overlap (2,3) = 33 (18.2% of Union (2,3))
Union (2,3) = 181 (83.4% of Total Union)
Overlap (1,2,3) = 26 (12% of union)
Just in 1 = 38 (17.5% of union) (55.3% overlapped)
Just in 2 = 58 (26.7% of union) (42.7% overlapped)
Just in 3 = 66 (30.4% of union) (38.7% overlapped)


The following lists correspond to the different overlappings between the lists, printing the PROTEIN_NODES name and the FDR value: 


Intersection (26): 
1	[ASNS	1.49902952973	FDR=1.13667556878E-6	Var=0.028473747332883083	#psms=6]
2	[HMGCS1	1.42141484575	FDR=2.5399628065E-6	Var=0.024902904950665744	#psms=20]
3	[VLDLR	0.915525369242	FDR=0.0196174897496	Var=0.024112519393382843	#psms=21]
4	[FADS2	2.22405279889	FDR=1.68101896039E-12	Var=0.04424805751985458	#psms=6]
5	[DST,THBS1,THBS2	1.26966472222	FDR=7.50112457161E-5	Var=0.025320653756107533	#psms=13]
6	[SMAD1,SMAD2,SMAD3,SMAD5,SMAD9	1.41570255199	FDR=1.34133634962E-4	Var=0.04427339030925525	#psms=4]
7	[FN1	1.22401485592	FDR=1.50588967253E-4	Var=0.02526431163855654	#psms=16]
8	[MFGE8	-1.05339070357	FDR=1.51994493815E-4	Var=0.021359464793734212	#psms=60]
9	[CBS	1.31220456145	FDR=2.76860547988E-4	Var=0.03798316832228635	#psms=6]
10	[GJA1	1.15276544598	FDR=5.20437298797E-4	Var=0.024666236061038762	#psms=12]
11	[COL11A1	1.05892733664	FDR=0.00297426076227	Var=0.025231834671429643	#psms=13]
12	[BCAT1	1.02362037365	FDR=0.00407878812159	Var=0.023293889600406355	#psms=39]
13	[GYS1	0.979472283557	FDR=0.00674857618242	Var=0.021779384524497774	#psms=33]
14	[GALNT1	1.00326848501	FDR=0.00713868056622	Var=0.025107947853406597	#psms=16]
15	[FTH1	-0.774886694325	FDR=0.0205488807321	Var=0.023449106752135115	#psms=29]
16	[P4HA2	0.831895627217	FDR=0.0459147227959	Var=0.022606449984463615	#psms=53]
17	[HSPG2	0.822185326135	FDR=0.0425163241433	Var=0.02037588604083698	#psms=85]
18	[ORC5,PLOD2	0.908568033401	FDR=0.0195531339311	Var=0.022716518697170472	#psms=33]
19	[ITGA5	0.908037081208	FDR=0.0191500069876	Var=0.02272151114781399	#psms=23]
20	[ERO1A	0.908665848157	FDR=0.0161862170785	Var=0.020844955090628194	#psms=96]
21	[SPARC	0.950883553024	FDR=0.0111899842286	Var=0.022802623017007195	#psms=22]
22	[PSAT1	1.24102075708	FDR=7.4211857087E-5	Var=0.022925350951431393	#psms=39]
23	[LOXL2	1.27082317853	FDR=7.22712288277E-5	Var=0.025910956375769206	#psms=16]
24	[MOV10	1.32453735232	FDR=4.64288832852E-5	Var=0.028078837418580277	#psms=11]
25	[CA9	1.26033019611	FDR=4.56831670018E-5	Var=0.022268383197575743	#psms=35]
26	[FTL	-1.24215851511	FDR=5.05826927554E-6	Var=0.023376404983415942	#psms=22]

Unique to: RW (38)
1	[MIF	-1.39991724426	FDR=1.15419136953E-5	Var=0.04156702461964517	#psms=16]
2	[BRD3	-1.28708179289	FDR=7.4609622438E-5	Var=0.040348692471837505	#psms=7]
3	[FUT8	-0.874255864619	FDR=0.0106682080581	Var=0.029144273740259904	#psms=3]
4	[COG7	1.07566957677	FDR=0.0154886692694	Var=0.04280344612531006	#psms=3]
5	[MMP15	1.05167507833	FDR=0.0174664141215	Var=0.041319993863463085	#psms=3]
6	[GPNMB	-0.876041057573	FDR=0.0176133612874	Var=0.034813784650142184	#psms=12]
7	[EFEMP2	1.05043090361	FDR=0.0176882554825	Var=0.04094249780651749	#psms=3]
8	[FIS1	-1.12029423372	FDR=0.0299608115494	Var=0.08582731016174798	#psms=3]
9	[NT5C	-0.836414598203	FDR=0.0347546818332	Var=0.03910383836366322	#psms=7]
10	[NDUFAF1	-0.834554596928	FDR=0.0397832342827	Var=0.04091606947523016	#psms=5]
11	[FAM21A,FAM21B,FAM21C	-1.15200309345	FDR=0.0459317236962	Var=0.105166181451179	#psms=6]
12	[NUDCD3	-0.843891090087	FDR=0.0486112697482	Var=0.045947108406931794	#psms=3]
13	[NDRG4	-0.8769112416	FDR=0.0295079408825	Var=0.04275519874493582	#psms=6]
14	[PRKDC,VPS26A	-1.59946207042	FDR=1.52264904296E-4	Var=0.08515785286042672	#psms=9]
15	[GNB1,GNB2,GNB3,GNB4	-1.18445082279	FDR=3.84039469998E-4	Var=0.040533537448000846	#psms=8]
16	[SMPD4	-1.18702400593	FDR=6.17132040221E-4	Var=0.04436333343366013	#psms=3]
17	[MRE11A	-1.13239000806	FDR=7.37421465342E-4	Var=0.03922927836657316	#psms=3]
18	[CBLB,DKFZp779A0729	1.28443236353	FDR=9.56687948391E-4	Var=0.043936364678503335	#psms=4]
19	[ENPP2	1.09589535892	FDR=0.0103488176527	Var=0.04040939267152964	#psms=6]
20	[CTSD	-0.939198709521	FDR=0.0103442469509	Var=0.03736624694595215	#psms=19]
21	[SIRPA,SIRPB1	-1.251538767	FDR=0.0101916096821	Var=0.08598514191219057	#psms=9]
22	[PSPH	1.09718741229	FDR=0.0100168892503	Var=0.04064353667641737	#psms=4]
23	[JAK1	-1.01551459701	FDR=0.00604171143555	Var=0.04183440192534903	#psms=3]
24	[SUPV3L1	-0.936470138905	FDR=0.00434740305413	Var=0.028998920002867374	#psms=8]
25	[NIT1	-1.65953438176	FDR=6.47338891241E-8	Var=0.042735512374216515	#psms=7]
26	[GPT2	1.7904557538	FDR=4.63065928269E-8	Var=0.041316152895064184	#psms=3]
27	[UBE4A	1.99486165873	FDR=2.98105232807E-10	Var=0.04147091556788849	#psms=11]
28	[UBL7	-2.85048564521	FDR=0.0	Var=0.0774801670969568	#psms=5]
29	[THUMPD3	-3.44509001378	FDR=0.0	Var=0.042739289477418854	#psms=4]
30	[LMF2	-3.83650126772	FDR=0.0	Var=0.08637510164802702	#psms=3]
31	[MYH10,MYH11,MYH14,MYH9	-5.05889368905	FDR=0.0	Var=0.0850207706885046	#psms=7]
32	[STAU1	-3.78266757949	FDR=0.0	Var=0.07263780555465793	#psms=8]
33	[SMARCAD1	-1.94341647163	FDR=1.08427907229E-6	Var=0.08550152393758327	#psms=4]
34	[ECE2	1.036814925	FDR=0.0197369831178	Var=0.04130271453609074	#psms=3]
35	[IBA57	-0.911784771087	FDR=0.0206146930176	Var=0.042964989805110335	#psms=4]
36	[IGF1R	-0.879344881973	FDR=0.0234327104486	Var=0.039576021594976085	#psms=6]
37	[SLC25A16	-0.870042272568	FDR=0.0278610496085	Var=0.04060569687771303	#psms=8]
38	[APP	-1.05905086454	FDR=0.029181119344	Var=0.07441823116828218	#psms=4]

Unique to: WT (58)
1	[ADSSL1	0.826000654806	FDR=0.0226347286862	Var=0.01329089975046473	#psms=4]
2	[ITGAV	-0.883790655896	FDR=0.0214331639457	Var=0.013036214084941277	#psms=5]
3	[ANKMY2	0.762350816756	FDR=0.0471776204485	Var=0.013237571057764312	#psms=4]
4	[NADSYN1	0.816958717931	FDR=0.0457106468187	Var=0.021391432333857263	#psms=3]
5	[LPCAT1	0.799256632793	FDR=0.0448920288646	Var=0.018187960626560924	#psms=5]
6	[AFG3L2	-0.800170407827	FDR=0.0439306870509	Var=0.009569048828336984	#psms=11]
7	[BCL2L1	1.17632277264	FDR=4.71436313077E-4	Var=0.022999336005284938	#psms=5]
8	[MGEA5	-1.21759143507	FDR=4.06549565402E-4	Var=0.02044596284422332	#psms=5]
9	[ME3	-1.16654082146	FDR=2.95089444336E-4	Var=0.012782344169386698	#psms=21]
10	[RPF2	-1.40638510828	FDR=2.79583078168E-6	Var=0.013132502879267295	#psms=3]
11	[AP2A1,AP2A2,NUDT9	-1.51457317283	FDR=2.2535748919E-6	Var=0.021749691857249544	#psms=9]
12	[WDR4	-1.51457317283	FDR=1.7763874193E-6	Var=0.020462100896901494	#psms=5]
13	[CADM4	-1.51457317283	FDR=1.77320642821E-6	Var=0.020305285730854238	#psms=5]
14	[MAP2K4	-2.12029423372	FDR=1.80712587751E-13	Var=0.019349363811568633	#psms=5]
15	[MESDC2	-2.05889368905	FDR=5.17239584497E-12	Var=0.022576391601792353	#psms=3]
16	[SUSD5	-2.12029423372	FDR=2.04506411805E-11	Var=0.030713298262002326	#psms=4]
17	[EML1	-2.05889368905	FDR=4.65813270309E-11	Var=0.028552778674176292	#psms=6]
18	[TSTA3	-0.90025642728	FDR=0.0269827453504	Var=0.01852573804378209	#psms=4]
19	[APPL2	-0.915935735212	FDR=0.0285072180763	Var=0.021670640450308896	#psms=4]
20	[ACAT1	-0.81964316994	FDR=0.033882589885	Var=0.009281865235680965	#psms=4]
21	[HIST1H1A,HIST1H1C,HIST1H1D,HIST1H1E,HIST1H1T	-0.803595269305	FDR=0.0352439626193	Var=0.007443517852178804	#psms=7]
22	[NFX1	-2.39592867633	FDR=0.0	Var=0.02339190321476708	#psms=4]
23	[KIF13B	-5.64385618977	FDR=0.0	Var=0.019958078225293618	#psms=3]
24	[NFXL1	-6.64385618977	FDR=0.0	Var=0.020820378487580726	#psms=11]
25	[WDR33	-3.32192809489	FDR=0.0	Var=0.020684095860267624	#psms=7]
26	[WDR77	-2.81514499935	FDR=0.0	Var=0.016561422601349383	#psms=8]
27	[DBN1	-4.64385618977	FDR=0.0	Var=0.01970297263703374	#psms=5]
28	[MYO18A	-3.23772920339	FDR=0.0	Var=0.012076962972832474	#psms=5]
29	[FLRT2	2.5993177937	FDR=0.0	Var=0.019164097938888253	#psms=4]
30	[PITHD1	-3.47393118833	FDR=0.0	Var=0.02201530307226255	#psms=6]
31	[OCIAD2	-2.251538767	FDR=6.48711853466E-14	Var=0.02484465740930336	#psms=4]
32	[PARD3B	-1.35845397091	FDR=9.81874329042E-5	Var=0.026427483811309983	#psms=6]
33	[NDUFA12	-1.25385174032	FDR=6.63063719208E-5	Var=0.01312347388370167	#psms=3]
34	[PTCD3	-1.35845397091	FDR=3.54221613882E-5	Var=0.020494694356784346	#psms=4]
35	[AHR	-1.2960264881	FDR=3.21356407214E-5	Var=0.013651518470162268	#psms=4]
36	[RELA	1.9107326619	FDR=1.39415005856E-10	Var=0.024810339810810763	#psms=4]
37	[ITIH5	1.79486390743	FDR=2.05434069755E-10	Var=0.017452751989503284	#psms=3]
38	[KIAA1429	-1.78587519465	FDR=4.13909610934E-8	Var=0.029281689131265425	#psms=3]
39	[UROD	1.59039935587	FDR=1.01618462978E-7	Var=0.020472771665842993	#psms=5]
40	[TRAPPC1	-1.59946207042	FDR=6.22508645751E-7	Var=0.023500312840072632	#psms=7]
41	[MGST1	-1.18442457114	FDR=7.08821992495E-4	Var=0.020576171425333734	#psms=5]
42	[GORASP2	-1.25059709393	FDR=8.1576702848E-4	Var=0.029858073149872433	#psms=3]
43	[ZFX,ZFY	-1.1351492112	FDR=0.00116415677448	Var=0.018314987057104964	#psms=4]
44	[FEN1	1.07724299893	FDR=0.00154096058696	Var=0.020039918523076735	#psms=6]
45	[NUDT5	-1.12029423372	FDR=0.00176049894657	Var=0.01980407710001724	#psms=6]
46	[APTX	-1.11528435948	FDR=0.00251179991665	Var=0.02251517157250262	#psms=6]
47	[GPM6A	0.971713600981	FDR=0.00254938181448	Var=0.011564344388696414	#psms=7]
48	[SH3BP4	-1.09150442883	FDR=0.00270804615219	Var=0.020407083135970814	#psms=7]
49	[LRRFIP1	0.569438951328	FDR=0.00312328556834	Var=-0.02616672957897698	#psms=13]
50	[ASF1A	0.917075470227	FDR=0.00352824674342	Var=0.007748705857943978	#psms=3]
51	[SRSF5	-1.05889368905	FDR=0.00469597727262	Var=0.021213023513308896	#psms=4]
52	[SOD2	-0.998931937196	FDR=0.0049956803922	Var=0.014188318976252563	#psms=5]
53	[RALGAPB	-1.04791424814	FDR=0.00542438998289	Var=0.02156068770124013	#psms=4]
54	[EEFSEC	1.05658352837	FDR=0.00551060220058	Var=0.030754357376724308	#psms=4]
55	[HSPA1B,HSPA6,HSPA7	0.89089242775	FDR=0.00904135360561	Var=0.012680684762544404	#psms=7]
56	[CRIPT	-0.880769646945	FDR=0.0107654431338	Var=0.005877417937576084	#psms=17]
57	[TMLHE	-0.885010197436	FDR=0.0118614313666	Var=0.007341741877410148	#psms=11]
58	[SORT1	0.817054063506	FDR=0.017703374771	Var=0.009313537952375847	#psms=5]

Unique to: lacZ (66)
1	[RRAGC,RRAGD	-0.75155911826	FDR=0.0143139170616	Var=0.013870808062308553	#psms=7]
2	[SCAF11	-1.02914634566	FDR=0.0136464609437	Var=0.0505331641666931	#psms=6]
3	[GRN	-0.735278233864	FDR=0.0135837778971	Var=0.011554300670339848	#psms=8]
4	[CUX1	-0.744840112219	FDR=0.0133658937943	Var=0.01238225820218287	#psms=6]
5	[PDP1	-0.772422634895	FDR=0.0131472972846	Var=0.015309950806677027	#psms=4]
6	[GMPR2	-0.755917038758	FDR=0.0116759411471	Var=0.012561367546993123	#psms=6]
7	[TPD52	0.781177901517	FDR=0.00928606727518	Var=0.014989027947940806	#psms=3]
8	[ACAD9	-0.761410376418	FDR=0.00894193733632	Var=0.011295627404377503	#psms=20]
9	[OCIAD1	0.79831590771	FDR=0.00750435250372	Var=0.015436862143139976	#psms=3]
10	[MATN2	0.742951109966	FDR=0.00739716720197	Var=0.009470073622773746	#psms=6]
11	[VARS	-0.785875194647	FDR=0.0465774703642	Var=0.029964785714429884	#psms=4]
12	[HN1	0.649848866677	FDR=0.0371183144687	Var=0.011026271837577085	#psms=6]
13	[UNC13D	0.627911210009	FDR=0.0358640157235	Var=0.008110222852377426	#psms=9]
14	[TIMP3	0.647076544455	FDR=0.0352732515714	Var=0.010188244751021064	#psms=7]
15	[CTNNA1,CTNNA2	-0.81096617561	FDR=0.0345030266688	Var=0.029957286271860957	#psms=4]
16	[EIF2A	-0.81096617561	FDR=0.0344593601873	Var=0.030031624820235605	#psms=4]
17	[P4HA1	0.610958007371	FDR=0.0344271636298	Var=0.005742401328415379	#psms=26]
18	[GTF2F1	-1.15200309345	FDR=3.00233945358E-4	Var=0.030811714838504103	#psms=4]
19	[RAB10	-1.15200309345	FDR=2.60613788384E-4	Var=0.0299585766378626	#psms=7]
20	[SLC29A1	1.18269229752	FDR=1.49076537076E-4	Var=0.030886184960375672	#psms=4]
21	[ERBB2IP	-1.35845397091	FDR=1.06865216851E-4	Var=0.04604442467194855	#psms=3]
22	[ST13,ST13P4,ST13P5	-1.04386596537	FDR=9.2097223417E-5	Var=0.014823667203193565	#psms=3]
23	[NAT10	-1.05899396632	FDR=7.99898171392E-5	Var=0.015373601774737967	#psms=10]
24	[BCAR1	1.1027128921	FDR=6.225677236E-5	Var=0.019023985747105204	#psms=4]
25	[SORBS3	-0.801929217773	FDR=0.0165976735508	Var=0.021276223824020626	#psms=12]
26	[IPO5	0.706569072947	FDR=0.0166682556061	Var=0.011422823831238656	#psms=3]
27	[SDHB	-0.724068533695	FDR=0.0166985680088	Var=0.012254040060412382	#psms=5]
28	[TTC38	-0.819151838995	FDR=0.0167352317621	Var=0.02366910483283462	#psms=5]
29	[TOM1L2	0.723758925654	FDR=0.0185809264294	Var=0.014366209479220243	#psms=5]
30	[SUCLG1	-0.712831932121	FDR=0.0186919598676	Var=0.01177742073521891	#psms=14]
31	[CHPF	0.847996906555	FDR=0.0192643133313	Var=0.03067197556335719	#psms=4]
32	[DAP3	-0.798401311871	FDR=0.0218143348695	Var=0.023598510194547406	#psms=6]
33	[ALDH2	-0.695800138756	FDR=0.0227707704394	Var=0.011328461639395536	#psms=3]
34	[SUPT6H	0.871843648509	FDR=0.0147784461542	Var=0.030461732632053047	#psms=3]
35	[CPSF1	-4.05889368905	FDR=0.0	Var=0.03147672136841231	#psms=8]
36	[PRDX4	-1.86181298864	FDR=0.0	Var=0.015160047381962692	#psms=13]
37	[EPB41,EPB41L1,EPB41L2,EPB41L3	-2.05941464824	FDR=0.0	Var=0.016263339790260546	#psms=4]
38	[GAPDH	2.11511621884	FDR=0.0	Var=0.023782512515894846	#psms=3]
39	[FAF2	-2.55639334852	FDR=0.0	Var=0.02936325923999309	#psms=7]
40	[C1orf52	-2.64385618977	FDR=0.0	Var=0.029892096491323582	#psms=5]
41	[ARMC10	-1.68895387794	FDR=4.00568467285E-13	Var=0.01539409851688918	#psms=4]
42	[COL18A1	0.5807694251	FDR=0.0469464000202	Var=0.004561534931156431	#psms=33]
43	[IDH3B	-0.677721092531	FDR=0.0487104561113	Var=0.015377946597920956	#psms=4]
44	[STOML2	-0.704558829567	FDR=0.0488339704372	Var=0.01889670099368666	#psms=3]
45	[REC8	0.672360648434	FDR=0.0320571137596	Var=0.0123373168343153	#psms=3]
46	[PTPRK	-0.69235941772	FDR=0.0319465868729	Var=0.013305420132130845	#psms=5]
47	[LSG1	-0.903881828638	FDR=0.00198856556439	Var=0.016600859687012665	#psms=4]
48	[PDHB	-0.905986624735	FDR=0.00167566739509	Var=0.015730789608860454	#psms=4]
49	[MME	-0.882246732648	FDR=0.00119073125503	Var=0.011832241776933667	#psms=5]
50	[CPOX	-0.969535821158	FDR=9.68953069554E-4	Var=0.01906110614259388	#psms=3]
51	[MAT2B	-0.95045463796	FDR=7.06036289974E-4	Var=0.0157385035183588	#psms=7]
52	[NSUN2	-1.0892673381	FDR=6.9060394115E-4	Var=0.029417620568434378	#psms=4]
53	[UBA6	-2.32192809489	FDR=0.0	Var=0.02959832292360461	#psms=4]
54	[HBA1	-2.64385618977	FDR=0.0	Var=0.029974361494640184	#psms=3]
55	[FAM102A	-5.05889368905	FDR=0.0	Var=0.029295728806327	#psms=4]
56	[UBXN1	-1.43440282415	FDR=1.75206737737E-6	Var=0.031597439503274476	#psms=5]
57	[RAVER1	-1.34876280986	FDR=2.36336443852E-6	Var=0.025759814276783456	#psms=3]
58	[NTPCR	1.37851162325	FDR=2.44531120422E-6	Var=0.029453193995020673	#psms=6]
59	[VTA1	-1.17582225739	FDR=5.43530713462E-6	Var=0.015296249252537029	#psms=3]
60	[CERS2	1.2177622547	FDR=1.26193882132E-5	Var=0.022809875949462193	#psms=5]
61	[MCFD2	-1.02914634566	FDR=0.00216376649941	Var=0.03067935063497734	#psms=3]
62	[SERPINB8,SERPINB9	-0.874451664779	FDR=0.00266852326482	Var=0.015746954042276155	#psms=7]
63	[PPP4R1,PPP4R1L	0.928228490659	FDR=0.00277915829452	Var=0.022933706404734626	#psms=4]
64	[PTMA,SPAG9	-1.0	FDR=0.00289756602505	Var=0.030285766640821186	#psms=3]
65	[RPF1	0.739182360334	FDR=0.00518726903143	Var=0.007219747447187614	#psms=10]
66	[NIFK	-0.943416471634	FDR=0.0064878336566	Var=0.029956821928145066	#psms=6]