hovlinc_supplements

Some supplementary files for the hovlinc paper:

Yue Chen^#, Fei Qi^#*, Fan Gao, Huifen Cao, Dongyang Xu, Kourosh Salehi-Ashtiani, and Philipp Kapranov*. Hovlinc is a recently evolved class of ribozyme found in human lncRNA. Nat Chem Biol 17(5), 601–607 (2021). https://doi.org/10.1038/s41589-021-00763-0

alignments

Multiple sequence alignments:

• MSA_all_homologs.fa: alignment of human hovlinc and 75 homologous sequences
• MSA_hominins.fa: alignment of the 3 active sequences from human, chimpanzee and bonobo

descr

Descriptors of the RNA sequence-structure patterns of some known ribozyme classes. These descriptors were used as input to the RNAMotif program to check whether hovlinc ribozyme is an instance of these known ribozymes.

script

R code for calculating the k_obs and pK_a of hovlinc ribozyme.