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Welcome to the QUAIL wiki!

Overview of QUAIL

QUAIL (quantile integral linear model) is a quantile regression-based framework to estimate genetic effects on the variance of quantitative traits.

The QUAIL software can be used to

• Genome-wide vQTL analysis - QUAIL constructs a quantile integral phenotype which aggregates information from all quantile levels, and only requires fitting two linear regressions per SNP in genome-wide analysis.
• Evaluating the vPGS performance - QUAIL can be extended to continuous predictors such as vPGS and quantify the performance of vPGS in predicting the phenotypic variability.

In this wiki, we provided short tutorials describing the two basic functions (Genome-wide vQTL analysis and Evaluating the vPGS performance) in QUAIL.

Contents of the wiki

• Install QUAIL and prepare the data required.
• Genome-wide vQTL analysis
• Evaluate the predictive performance of vPGS