Display action of the drug on the target

website/static/js_templates/node_tooltip.njk

@@ -26,18 +26,27 @@
 {% endif %}
 
 {% if node.type === types.drug %}
+  {% set drug = node.data.drug %}
+  {% set interaction = node.data.interaction %}
   <div class="badges">
-  {% for group in node.data.groups %}
+  {% for group in drug.groups %}
     <div class="badge {{ group }}">{{ group }}</div>
   {% endfor %}
   </div>
   <div>
-  {% if node.data.type %}
-  {{ node.data.type | title }}
+  {% if drug.type %}
+  {{ drug.type | title }}
+  {% endif %}
   </div>
+  {% if interaction.actions %}
+    <div>
+    {% for action in interaction.actions %}
+      {{ action | title }}
+    {% endfor %}
+    </div>
   {% endif %}
   <p>
-    See more in DrugBank: <a href="https://www.drugbank.ca/drugs/{{ node.data.drugbank }}">{{ node.data.drugbank }}</a>
+    See more in DrugBank: <a href="https://www.drugbank.ca/drugs/{{ drug.drugbank }}">{{ drug.drugbank }}</a>
   </p>
 {% endif %}
 

website/static/network.js

@@ -915,14 +915,14 @@ var Network = function ()
         kinase_nodes.forEach(function(kinase) {
             var kinase_drugs = []
             kinase.drugs_targeting_kinase_gene.forEach(
-                function(drug_data)
+                function(target_data)
                 {
                     var drug_node = {
-                        name: drug_data.name,
+                        name: target_data['drug'].name,
                         r: config.radius,
                         type: types.drug,
                         group: kinase.group,
-                        data: drug_data
+                        data: target_data
                     }
                     addEdge(drug_node, kinase)
                     kinase_drugs.push(drug_node)
@@ -1450,4 +1450,4 @@ var Network = function ()
     }
 
     return public_space
-}
+}

website/tests/views/test_network.py

@@ -53,6 +53,7 @@ def create_network():
     target = DrugTarget()
     target.gene = known_interactor_of_x.protein.gene
     target.drug = drug
+    target.actions = {'antagonist', 'inhibitor'}
 
     group = KinaseGroup(
         name='Group of kinases',
@@ -130,11 +131,12 @@ def test_representation(self):
         assert kinase['name'] == 'Kinase Y'
 
         # test kinase drugs
-        drugs = kinase['drugs_targeting_kinase_gene']
-        assert len(drugs) == 1
-        drug = drugs[0]
+        targets = kinase['drugs_targeting_kinase_gene']
+        assert len(targets) == 1
+        drug = targets[0]['drug']
         assert drug['name'] == 'Drug targeting Kinase Y'
         assert drug['drugbank'] == 'DB01'
+        assert set(targets[0]['interaction']['actions']) == {'antagonist', 'inhibitor'}
 
         # test sites
         assert len(representation['sites']) == 2

website/views/_commons.py

@@ -1,4 +1,5 @@
 from collections import defaultdict
+from typing import Dict, Set
 
 from models import Gene
 from models.bio.drug import Drug, DrugTarget
@@ -22,7 +23,7 @@ def represent_mutation(mutation, data_filter, representation_type=dict):
     )
 
 
-def drugs_interacting_with_kinases(filter_manager, kinases):
+def drugs_interacting_with_kinases(filter_manager, kinases) -> Dict[Gene, Set[DrugTarget]]:
     from sqlalchemy import and_
 
     kinase_gene_ids = [kinase.protein.gene_id for kinase in kinases if kinase.protein]
@@ -34,8 +35,8 @@ def drugs_interacting_with_kinases(filter_manager, kinases):
         ),
         lambda query: query.join(DrugTarget)
     )
-    drugs_by_kinase = defaultdict(set)
+    targets_by_kinase = defaultdict(set)
     for drug in drugs:
-        for target_gene in drug.target_genes:
-            drugs_by_kinase[target_gene].add(drug)
-    return drugs_by_kinase
+        for target in drug.targets:
+            targets_by_kinase[target.gene].add(target)
+    return targets_by_kinase

website/views/network.py

@@ -92,7 +92,7 @@ def __init__(self, protein, filter_manager, include_kinases_from_groups=False):
 
         protein_kinases_names = [kinase.name for kinase in kinases]
 
-        drugs_by_kinase = drugs_interacting_with_kinases(filter_manager, kinases)
+        targets_by_kinase = drugs_interacting_with_kinases(filter_manager, kinases)
 
         kinase_reprs = []
         for kinase, count in kinases_counts.items():
@@ -101,7 +101,13 @@ def __init__(self, protein, filter_manager, include_kinases_from_groups=False):
                 json_repr['protein']['mutations_count'] = count
 
             json_repr['drugs_targeting_kinase_gene'] = [
-                drug.to_json() for drug in drugs_by_kinase[kinase.protein.gene]
+                {
+                    'drug': target.drug.to_json(),
+                    'interaction': {
+                        'actions': list(target.actions)
+                    }
+                }
+                for target in targets_by_kinase[kinase.protein.gene]
             ]
             kinase_reprs.append(json_repr)
 
@@ -261,7 +267,7 @@ def choose_impact(mutations, site, kinase_name, mimp_list):
                     continue
                 impact = choose_impact(site_mutations, site, kinase_name, site_mimp_kinases)
                 drugs = kinase['drugs_targeting_kinase_gene']
-                drugs = ','.join([drug['name'] for drug in drugs]) or ''
+                drugs = ','.join([drug['drug']['name'] for drug in drugs]) or ''
                 row = protein_and_site + [impact, kinase_name, drugs]
                 content.append('\t'.join(row))