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bbbq_article

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DOI

The article 'Transmembrane helices are an overlooked and evolutionarily conserved source of major histocompatibility complex class I and II epitopes', by Bilderbeek, Baranov, van den Bogaart and Bianchi.

Article download and citation

This article was published in Frontiers in Immunology, with a pre-print on bioRxiv.

Frontiers in Immunology

Bilderbeek, Richèl JC, et al. "Transmembrane Helices Are an Over-Presented and Evolutionarily Conserved Source of Major Histocompatibility Complex Class I and II Epitopes." Frontiers in immunology 12 (2021).
@article{bilderbeek2021transmembrane,
  title={Transmembrane Helices Are an Over-Presented and Evolutionarily Conserved Source of Major Histocompatibility Complex Class I and II Epitopes},
  author={Bilderbeek, Rich{\`e}l JC and Baranov, Maksim V and Van Den Bogaart, Geert and Bianchi, Frans},
  journal={Frontiers in immunology},
  volume={12},
  year={2021},
  publisher={Frontiers Media SA}
}

bioRxiv

Bilderbeek, Richèl JC, et al. "Transmembrane helices are an overlooked and evolutionarily conserved source of major histocompatibility complex class I and II epitopes." bioRxiv (2021).
@article{bilderbeek2021transmembrane,
  title={Transmembrane helices are an overlooked and evolutionarily conserved source of major histocompatibility complex class {I} and {II} epitopes},
  author={Bilderbeek, Richèl JC and Baranov, Maxim and van den Bogaart, Geert and Bianchi, Frans},
  journal={bioRxiv},
  year={2021},
  publisher={Cold Spring Harbor Laboratory}
}

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Zip the article for Frontiers

make frontiers

Will create a file ~/frontiers.zip with all files for a Frontiers submission.

Figure sources

See numbered_figure_files.csv where the numbered figures (figure_1a.tiff, etc) originally come from.

The subfigures (e.g. figure 1a, figure 1b), were put into TIFF figure files (e.g. figure 1, figure 2) by @fransbianchi.

The figure TIFF files (e.g. figure_1.tiff, figure_2.tiff) were converted to EPS files (e.g. figure_1.eps, figure_2.eps) using https://www.freeconvert.com/tiff-to-eps.

Re-do the analysis

Naturally presented epitopes are derived from TMH

DOI

See https://github.com/richelbilderbeek/bbbq_article_issue_157.

TMH-derived epitopes are over-presented

See https://github.com/richelbilderbeek/bbbq_1_smart.

DOI

TMHs are conserved

See https://github.com/richelbilderbeek/ncbi_peregrine for the scripts.

DOI

See https://github.com/richelbilderbeek/ncbi_results to see how the results are processed.

DOI

Dependencies

Repository GitHub Actions logo
bbbq R-CMD-check
bbbq_1_smart make
bbbq_article_issue_157 R-CMD-check
ncbi_peregrine R-CMD-check
ncbi_results R-CMD-check

How did you make the comparison figure?

I made the comparison figure using:

compare bbbq_1_smart_results/fig_f_tmh_2_panel.png bbbq_1_smart_2aa_results/fig_f_tmh_2_panel.png compare_fig_f_tmh_2_panel.png

The comparison figure:

Labels

Fig Label
1A fig:bbbq_1_smart_results
1B fig:hydrophobicity_1
1C fig:hydrophobicity_2
2 fig:elution
2A fig:2a
2B fig:2b
3A fig:f_snps_found_and_expected
3B fig:f_tmh_ncbi
3C fig:conservation
4A fig:f_snps_found_and_expected_per_spanner
4B fig:conservation_per_spanner
4C fig:f_tmh_ncbi_per_spanner
S1 fig:bianch_et_al_2017_1a
S2 fig:bilderbeek_et_al_2021_1a
S3 fig:snp_rel_pos
S4 fig:thm_presentation_correlation
S5 fig:t_cells_present_tmh_derived_epitopes
S6 fig:f_tmh_mhc1_normalized
S7 fig:f_tmh_mhc2_normalized
S8 fig:rel_presentation_per_haplotype
S9 fig:rel_presentation
S10 fig:snps_per_gene_name_ncbi
S11 fig:snps_per_gene_name_processed
S12 fig:n_proteins_per_gene_name
S13 fig:fig_n_snps_per_tmp
S14 fig:fig_n_tmhs_per_protein
S15 fig:bbbq_1_smart_results_2aas
Tab Label
ST1 tab:ic50_binders_mhc1
ST2 tab:ic50_binders_mhc2
ST3 tab:ncbi_counts_1
ST4 tab:ncbi_counts_2
ST5 tab:tmh_binders_mhc2
ST6 tab:elution
ST7 tab:tmh_binders_mhc1
ST8 tab:haplotype_abbreviations
ST9 table:software_used
ST10 tab:f_tmh
ST11 tab:snp_stats
ST12 tab:snp_stats_per_spanner_single
ST13 tab:snp_stats_per_spanner_multi
ST14 tab:tmh_binders_mhc2_2aas
ST15 tab:tmh_binders_mhc1_2aas

Frontiers files

frontiers.aux
frontiersFPHY.cls
frontiersHLTH.cls
frontiersinHLTH&FPHY.bst
frontiersinSCNS_ENG_HUMS.bst
frontiers.log
frontiers.out
frontiers.pdf
frontiersSCNS.cls
frontiers_SupplementaryMaterial.tex
frontiers_suppmat.cls
frontiers.tex
logo1.eps
logo1-eps-converted-to.pdf
logo2.eps
logos.eps
logos-eps-converted-to.pdf
PDF examples
stfloats.sty
test.bib
YM-logo.eps