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examples.Rmd
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examples.Rmd
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---
title: "Examples"
author: "Richèl J.C. Bilderbeek"
date: "`r Sys.Date()`"
output: rmarkdown::html_vignette
vignette: >
%\VignetteIndexEntry{Examples}
%\VignetteEngine{knitr::rmarkdown}
%\VignetteEncoding{UTF-8}
---
```{r setup, include = FALSE}
knitr::opts_chunk$set(
collapse = TRUE,
comment = "#>"
)
```
```{r check_empty_cache_at_start, include = FALSE}
beastier::remove_beaustier_folders()
beastier::check_empty_beaustier_folders()
```
## Introduction
![](babette_logo.png)
This vignette shows some examples how to set up different inference models
in `babette`.
For all examples, do load `babette`:
```{r load_babette, results='hide', warning=FALSE, error=FALSE, message=FALSE}
library(babette)
```
All these examples check that `BEAST2` is installed at the default
location at `r get_default_beast2_path()`. If this is not the case,
we will use some fabricated output:
```{r}
posterior <- create_test_bbt_run_output()
posterior$anthus_aco_sub_trees <- posterior$anthus_aco_trees
names(posterior)
```
All examples read the alignment from a FASTA file (usually `my_fasta.fas`).
```{r}
fasta_filename <- get_babette_path("anthus_aco_sub.fas")
```
Instead of a full run, the MCMC chain length is shortened to 10K states,
with a measurement every 1K states:
```{r}
mcmc <- create_test_mcmc(chain_length = 10000)
```
We will re-create this MCMC setup,
as doing so initializes it with new filenames for
temporary files.
These temporary files should not exist before a run and should exist
after a run. Sure, there is the option to overwrite...
## Example #1: all default
Using all default settings, only specify a DNA alignment.
![Example #1: all default](all_default.png)
```{r example_1, cache=TRUE}
if (is_beast2_installed()) {
inference_model <- create_inference_model(
mcmc = mcmc
)
beast2_options <- create_beast2_options()
posterior <- bbt_run_from_model(
fasta_filename = fasta_filename,
inference_model = inference_model,
beast2_options = beast2_options
)
bbt_delete_temp_files(
inference_model = inference_model,
beast2_options = beast2_options
)
}
```
All other parameters are set to their defaults, as in BEAUti.
```{r fig.width=7, fig.height=7}
plot_densitree(posterior$anthus_aco_sub_trees, width = 2)
```
## Example #2: using an MRCA prior to specify a crown age
![Example #2: using an MRCA prior to specify a crown age](mrca_crown_age.png)
An alternative is to date the node of the most recent common ancestor
of all taxa.
Create the MCMC:
```{r}
mcmc <- create_test_mcmc(chain_length = 10000)
```
```{r example_2_mrca, cache=FALSE}
if (is_beast2_installed()) {
inference_model <- create_inference_model(
mcmc = mcmc,
mrca_prior = create_mrca_prior(
taxa_names = sample(get_taxa_names(fasta_filename), size = 3),
alignment_id = get_alignment_id(fasta_filename),
is_monophyletic = TRUE,
mrca_distr = create_normal_distr(
mean = 15.0,
sigma = 0.025
)
)
)
beast2_options <- create_beast2_options()
posterior <- bbt_run_from_model(
fasta_filename = fasta_filename,
inference_model = inference_model,
beast2_options = beast2_options
)
bbt_delete_temp_files(
inference_model = inference_model,
beast2_options = beast2_options
)
}
```
Here we use an MRCA prior with fixed (non-estimated) values of the mean
and standard deviation for the common ancestor node's time.
```{r fig.width=7, fig.height=7}
plot_densitree(posterior$anthus_aco_sub_trees, width = 2)
```
## Example #3: JC69 site model
![Example #3: JC69 site model](jc69_2_4.png)
```{r example_3, cache=TRUE}
if (is_beast2_installed()) {
inference_model <- create_inference_model(
site_model = create_jc69_site_model(),
mcmc = mcmc
)
beast2_options <- create_beast2_options()
posterior <- bbt_run_from_model(
fasta_filename = fasta_filename,
inference_model = inference_model,
beast2_options = beast2_options
)
bbt_delete_temp_files(
inference_model = inference_model,
beast2_options = beast2_options
)
}
```
```{r fig.width=7, fig.height=7}
plot_densitree(posterior$anthus_aco_sub_trees, width = 2)
```
## Example #4: Relaxed clock log normal
![Example #4: Relaxed clock log normal](rln_2_4.png)
```{r example_4, cache=TRUE}
if (is_beast2_installed()) {
inference_model <- create_inference_model(
clock_model = create_rln_clock_model(),
mcmc = mcmc
)
beast2_options <- create_beast2_options()
posterior <- bbt_run_from_model(
fasta_filename = fasta_filename,
inference_model = inference_model,
beast2_options = beast2_options
)
bbt_delete_temp_files(
inference_model = inference_model,
beast2_options = beast2_options
)
}
```
```{r fig.width=7, fig.height=7}
plot_densitree(posterior$anthus_aco_sub_trees, width = 2)
```
## Example #5: Birth-Death tree prior
![Example #5: Birth-Death tree prior](bd_2_4.png)
```{r example_5, cache=TRUE}
if (is_beast2_installed()) {
inference_model <- create_inference_model(
tree_prior = create_bd_tree_prior(),
mcmc = mcmc
)
beast2_options <- create_beast2_options()
posterior <- bbt_run_from_model(
fasta_filename = fasta_filename,
inference_model = inference_model,
beast2_options = beast2_options
)
bbt_delete_temp_files(
inference_model = inference_model,
beast2_options = beast2_options
)
}
```
```{r fig.width=7, fig.height=7}
plot_densitree(posterior$anthus_aco_sub_trees, width = 2)
```
## Example #6: Yule tree prior with a normally distributed birth rate
![Example #6: Yule tree prior with a normally distributed birth rate](birth_rate_normal_2_4.png)
```{r example_6, cache=TRUE}
if (is_beast2_installed()) {
inference_model <- create_inference_model(
tree_prior = create_yule_tree_prior(
birth_rate_distr = create_normal_distr(
mean = 1.0,
sigma = 0.1
)
),
mcmc = mcmc
)
beast2_options <- create_beast2_options()
posterior <- bbt_run_from_model(
fasta_filename = fasta_filename,
inference_model = inference_model,
beast2_options = beast2_options
)
bbt_delete_temp_files(
inference_model = inference_model,
beast2_options = beast2_options
)
}
```
```{r fig.width=7, fig.height=7}
plot_densitree(posterior$anthus_aco_sub_trees, width = 2)
```
Thanks to Yacine Ben Chehida for this use case
## Example #7: HKY site model with a non-zero proportion of invariants
![Example #7: HKY site model with a non-zero proportion of invariants](hky_prop_invariant_0_5_2_4.png)
```{r example_7, cache=TRUE}
if (is_beast2_installed()) {
inference_model <- create_inference_model(
site_model = create_hky_site_model(
gamma_site_model = create_gamma_site_model(prop_invariant = 0.5)
),
mcmc = mcmc
)
beast2_options <- create_beast2_options()
posterior <- bbt_run_from_model(
fasta_filename = fasta_filename,
inference_model = inference_model,
beast2_options = beast2_options
)
bbt_delete_temp_files(
inference_model = inference_model,
beast2_options = beast2_options
)
}
```
```{r fig.width=7, fig.height=7}
plot_densitree(posterior$anthus_aco_sub_trees, width = 2)
```
Thanks to Yacine Ben Chehida for this use case
## Example #8: Strict clock with a known clock rate
![Example #8: Strict clock with a known clock rate](strict_clock_rate_0_5_2_4.png)
```{r example_8, cache=TRUE}
if (is_beast2_installed()) {
inference_model <- create_inference_model(
clock_model = create_strict_clock_model(
clock_rate_param = 0.5
),
mcmc = mcmc
)
beast2_options <- create_beast2_options()
posterior <- bbt_run_from_model(
fasta_filename = fasta_filename,
inference_model = inference_model,
beast2_options = beast2_options
)
bbt_delete_temp_files(
inference_model = inference_model,
beast2_options = beast2_options
)
}
```
```{r fig.width=7, fig.height=7}
plot_densitree(posterior$anthus_aco_sub_trees, width = 2)
```
Thanks to Paul van Els and Yacine Ben Chehida for this use case.
```{r check_empty_cache_at_end, include = FALSE}
beastier::remove_beaustier_folders()
beastier::check_empty_beaustier_folders()
```