Skip to content
New issue

Have a question about this project? Sign up for a free GitHub account to open an issue and contact its maintainers and the community.

By clicking “Sign up for GitHub”, you agree to our terms of service and privacy statement. We’ll occasionally send you account related emails.

Already on GitHub? Sign in to your account

EG.5.1.13+Orf1a:R135S(rev) (1314 seqs global > 30 countries,further gaining Flip+S:A288S,P1162L 42 Seqs) #1074

Closed
aviczhl2 opened this issue Nov 10, 2023 · 12 comments
Labels
Big branch FLip = S:L455F / S:F456L Interesting diversity in the tree the tree shows multiple interesting branches Reversions To be proposed Green light for proposal

Comments

@aviczhl2
Copy link
Contributor

aviczhl2 commented Nov 10, 2023

There is a large EG.5.1+G670T(Orf1a:R135S)(rev) branch.

Orf1a:R135S was a known homoplastic reversion designated in BA.2.23 cov-lineages/pango-designation#546, so likely to be real.

EG.5.1+C12439T+G670T(Orf1a:R135S)(rev)

GISAID query: C12439T,C241T,-T670G, C2334T, T22930A
No. of seqs: 790(Australia, Belgium, Brazil, Canada, Chile, Denmark, UK, France, Germany, Greece, Iceland, Israel, Ireland, Italy,
Japan, Mexico, Netherlands, New Zealand, Peru, Portugal, Romania, South Korea, Spain, Sweden, Switzerland, USA)

GISAID query for sub-branch with S:A288S,P1162L,L455F: C12439T,C241T,-T670G, C2334T, G22927T

usher

image

@aviczhl2
Copy link
Contributor Author

image

It is faster than baseline EG.5.1 , and about the same speed with the whole EG.5.1 family(including Flips)

@FedeGueli
Copy link

i ve tried : C12439T,C241T,-T670G, C2334T, T22930A that gives 790

@FedeGueli FedeGueli added Reversions Interesting diversity in the tree the tree shows multiple interesting branches Big branch labels Nov 11, 2023
@aviczhl2 aviczhl2 changed the title EG.5.1+Orf1a:R135S(rev) (~1000 seqs) EG.5.1+Orf1a:R135S(rev) (790 seqs, 26 countries) Nov 11, 2023
@aviczhl2
Copy link
Contributor Author

i ve tried : C12439T,C241T,-T670G, C2334T, T22930A that gives 790

Oh I don't notice the C12439T mutation . Thanks for pointing out .

@FedeGueli
Copy link

cc @corneliusroemer maybe you could designate this one? the existence of one reversion in a defining mutation of BA.2 should be something to keep tracked also for potential recombinations in the future.

@aviczhl2 aviczhl2 changed the title EG.5.1+Orf1a:R135S(rev) (790 seqs, 26 countries) EG.5.1+Orf1a:R135S(rev) (840 seqs, 26 countries) Nov 16, 2023
@aviczhl2
Copy link
Contributor Author

862, Poland

@aviczhl2 aviczhl2 changed the title EG.5.1+Orf1a:R135S(rev) (840 seqs, 26 countries) EG.5.1+Orf1a:R135S(rev) (862 seqs, 27 countries) Nov 20, 2023
@aviczhl2 aviczhl2 changed the title EG.5.1+Orf1a:R135S(rev) (862 seqs, 27 countries) EG.5.1+Orf1a:R135S(rev) (942 seqs, 27 countries) Nov 25, 2023
@aviczhl2 aviczhl2 changed the title EG.5.1+Orf1a:R135S(rev) (942 seqs, 27 countries) EG.5.1.13+Orf1a:R135S(rev) (942 seqs, 27 countries) Nov 28, 2023
FedeGueli referenced this issue in cov-lineages/pango-designation Nov 28, 2023
@aviczhl2 aviczhl2 changed the title EG.5.1.13+Orf1a:R135S(rev) (942 seqs, 27 countries) EG.5.1.13+Orf1a:R135S(rev) (1036 seqs, 27 countries) Dec 3, 2023
@aviczhl2 aviczhl2 changed the title EG.5.1.13+Orf1a:R135S(rev) (1036 seqs, 27 countries) EG.5.1.13+Orf1a:R135S(rev) (1103 seqs, 27 countries) Dec 7, 2023
@Over-There-Is
Copy link

Shanghai/SCDC-XG11-15119/2023

@aviczhl2 aviczhl2 changed the title EG.5.1.13+Orf1a:R135S(rev) (1103 seqs, 27 countries) EG.5.1.13+Orf1a:R135S(rev) (1103 seqs, 27 countries, 21 with Flip+S:A288S,P1162L) Dec 10, 2023
@aviczhl2
Copy link
Contributor Author

1128, China.
There is a S:A288S,P1162L.L455F sub-branch of 21.

@aviczhl2 aviczhl2 changed the title EG.5.1.13+Orf1a:R135S(rev) (1103 seqs, 27 countries, 21 with Flip+S:A288S,P1162L) EG.5.1.13+Orf1a:R135S(rev) (1128 seqs, 28 countries, 21 with Flip+S:A288S,P1162L) Dec 10, 2023
@aviczhl2
Copy link
Contributor Author

aviczhl2 commented Dec 14, 2023

1189, Luxembourg, Norway.

Flip+288+1162 branch grows to 29.

@aviczhl2 aviczhl2 changed the title EG.5.1.13+Orf1a:R135S(rev) (1128 seqs, 28 countries, 21 with Flip+S:A288S,P1162L) EG.5.1.13+Orf1a:R135S(rev) (1189 seqs, 30 countries, 29 with Flip+S:A288S,P1162L) Dec 14, 2023
@aviczhl2
Copy link
Contributor Author

1218, Finland

@aviczhl2 aviczhl2 changed the title EG.5.1.13+Orf1a:R135S(rev) (1189 seqs, 30 countries, 29 with Flip+S:A288S,P1162L) EG.5.1.13+Orf1a:R135S(rev) (1218 seqs, 31 countries, 29 with Flip+S:A288S,P1162L) Dec 19, 2023
@aviczhl2 aviczhl2 changed the title EG.5.1.13+Orf1a:R135S(rev) (1218 seqs, 31 countries, 29 with Flip+S:A288S,P1162L) EG.5.1.13+Orf1a:R135S(rev) (1282 seqs, 31 countries, 31 with Flip+S:A288S,P1162L) Dec 24, 2023
@aviczhl2 aviczhl2 changed the title EG.5.1.13+Orf1a:R135S(rev) (1282 seqs, 31 countries, 31 with Flip+S:A288S,P1162L) EG.5.1.13+Orf1a:R135S(rev) (1307 seqs, 31 countries, 40 with Flip+S:A288S,P1162L) Dec 29, 2023
@aviczhl2
Copy link
Contributor Author

The Flip sub-lineage grows to 40.

@FedeGueli FedeGueli added To be proposed Green light for proposal FLip = S:L455F / S:F456L labels Dec 29, 2023
@FedeGueli FedeGueli changed the title EG.5.1.13+Orf1a:R135S(rev) (1307 seqs, 31 countries, 40 with Flip+S:A288S,P1162L) EG.5.1.13+Orf1a:R135S(rev) (1307 seqs, 31 countries, 42 with Flip+S:A288S,P1162L) Dec 29, 2023
@FedeGueli FedeGueli changed the title EG.5.1.13+Orf1a:R135S(rev) (1307 seqs, 31 countries, 42 with Flip+S:A288S,P1162L) EG.5.1.13+Orf1a:R135S(rev) (1314 seqs global > 30 countries,further gaining Flip+S:A288S,P1162L 42 Seqs Dec 29, 2023
@FedeGueli FedeGueli changed the title EG.5.1.13+Orf1a:R135S(rev) (1314 seqs global > 30 countries,further gaining Flip+S:A288S,P1162L 42 Seqs EG.5.1.13+Orf1a:R135S(rev) (1314 seqs global > 30 countries,further gaining Flip+S:A288S,P1162L 42 Seqs) Dec 29, 2023
@FedeGueli
Copy link

already +2 the flip branch

@FedeGueli
Copy link

FedeGueli commented Dec 29, 2023

i ve misssed to track this Flip sorry, great you found. propose it together with the parental big lineage.

Sign up for free to join this conversation on GitHub. Already have an account? Sign in to comment
Labels
Big branch FLip = S:L455F / S:F456L Interesting diversity in the tree the tree shows multiple interesting branches Reversions To be proposed Green light for proposal
Projects
None yet
Development

No branches or pull requests

3 participants