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JN.1* + A29086T with S:Q677H (96 Sequences) and a further sublineage with S:S680F (42 seqs) #1326

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krosa1910 opened this issue Jan 22, 2024 · 10 comments

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@krosa1910
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krosa1910 commented Jan 22, 2024

Edited by mod
JN.1*> A29086T > G23593T(S:Q677H)
Query:G23593T, A29086T,T3565C
Samples: 63
IDs:EPI_ISL_18598041, EPI_ISL_18639885, EPI_ISL_18685007,
EPI_ISL_18688698, EPI_ISL_18688878, EPI_ISL_18706617-18706618,
EPI_ISL_18706622, EPI_ISL_18711912, EPI_ISL_18720952,
EPI_ISL_18732956, EPI_ISL_18733298-18733299, EPI_ISL_18740816,
EPI_ISL_18740832, EPI_ISL_18740834, EPI_ISL_18751372,
EPI_ISL_18751611, EPI_ISL_18751613, EPI_ISL_18751615,
EPI_ISL_18751618, EPI_ISL_18751681, EPI_ISL_18751780,
EPI_ISL_18751989, EPI_ISL_18792064-18792065, EPI_ISL_18793124,
EPI_ISL_18823339, EPI_ISL_18823388, EPI_ISL_18823457,
EPI_ISL_18823585, EPI_ISL_18823643, EPI_ISL_18823661,
EPI_ISL_18823670, EPI_ISL_18823716, EPI_ISL_18823745,
EPI_ISL_18823758, EPI_ISL_18823868, EPI_ISL_18823898,
EPI_ISL_18841467, EPI_ISL_18853043, EPI_ISL_18853131,
EPI_ISL_18853143, EPI_ISL_18853161, EPI_ISL_18853171,
EPI_ISL_18853181, EPI_ISL_18853195, EPI_ISL_18853197,
EPI_ISL_18853202, EPI_ISL_18853219, EPI_ISL_18853282,
EPI_ISL_18853286, EPI_ISL_18853292, EPI_ISL_18853311,
EPI_ISL_18853404, EPI_ISL_18853406, EPI_ISL_18853426,
EPI_ISL_18858430, EPI_ISL_18858434, EPI_ISL_18858445,
EPI_ISL_18858560, EPI_ISL_18860243, EPI_ISL_18869604,

Tree:
Screenshot 2024-02-07 alle 10 38 54
https://nextstrain.org/fetch/genome-test.gi.ucsc.edu/trash/ct/subtreeAuspice1_genome_test_34002_34d1c0.json?c=gt-S_677&gmax=25384&gmin=21563&label=id:node_6903698

A sublineage has further acquired S:S680F in the FCS
Search: C23601T,T15756A,C18894T,G23593T,
Mutations Added: A29086T (a relatively large branch of JN.1*, nor sure if it is mentioned or not)->G23593T(S:Q677H) ,C23601T (S:S680F)
Samples: 29
First Sequence: EPI_ISL_18688878 Scotland 2023-11-30
Latest Sequence: EPI_ISL_18751611 South Korea 2024-01-02
Usher:
Screenshot 2024-01-23 at 2 39 58 AM
https://nextstrain.org/fetch/genome.ucsc.edu/trash/ct/singleSubtreeAuspice_genome_12c39_eb63d0.json?f_userOrOld=uploaded%20sample
Many of the sequences are actually trash as they contain too many reversions ( I hate South Korea for its trash sequences), but showing up in three countries is good enough for me, and if it is not completely an artefect, it could resemble the trend @LongDesertTrain have observed that multiple close to FCS mutations are now rising among JN.1*

@FedeGueli
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very good catch.

@krosa1910 krosa1910 changed the title JN.1* small branch with S:Q677H and S:S680F JN.1* small branch with S:Q677H and S:S680F (3 Scotland,4Japan,14 South Korea) Jan 23, 2024
@FedeGueli FedeGueli changed the title JN.1* small branch with S:Q677H and S:S680F (3 Scotland,4Japan,14 South Korea) JN.1* small branch with S:Q677H and S:S680F (3 Scotland,4Japan,19 South Korea) 26 Jan 26, 2024
@FedeGueli
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26 , a lot from S.Korea . 5 in January ( 2%)

@FedeGueli FedeGueli added the To be proposed Green light for proposal label Jan 26, 2024
@FedeGueli
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please propose it

@FedeGueli FedeGueli changed the title JN.1* small branch with S:Q677H and S:S680F (3 Scotland,4Japan,19 South Korea) 26 JN.1* + A29086T with S:Q677H (63 Sequences) and a further sublineage with S:S680F (29 seqs) Feb 7, 2024
@FedeGueli
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@krosa1910 i have reorganized the proposal cause it seems that the parental branch with S:Q677H is growing.
So please propose it in the way i displayed above. Thank you

@krosa1910 krosa1910 changed the title JN.1* + A29086T with S:Q677H (63 Sequences) and a further sublineage with S:S680F (29 seqs) JN.1* + A29086T with S:Q677H (81 Sequences) and a further sublineage with S:S680F (34 seqs) Feb 20, 2024
@krosa1910
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I think I would propose the Q677H branch, but the S680F also looks tempting so I would also include it.

@FedeGueli FedeGueli changed the title JN.1* + A29086T with S:Q677H (81 Sequences) and a further sublineage with S:S680F (34 seqs) JN.1* + A29086T with S:Q677H (96 Sequences) and a further sublineage with S:S680F (42 seqs) Mar 3, 2024
@FedeGueli
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please propose it especially the 680F branch

@krosa1910
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108 seq and 49 for branch, I think I will propose it tomorrow (too tired today)

@krosa1910
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Transferred.

@aviczhl2 aviczhl2 added this to the JN.1.36 milestone Mar 17, 2024
@FedeGueli
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Designated JN.1.36 via cov-lineages/pango-designation@99bec76

@FedeGueli FedeGueli added designated and removed To be proposed Green light for proposal labels Mar 17, 2024
FedeGueli referenced this issue in cov-lineages/pango-designation Mar 17, 2024
@FedeGueli
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The sublineage with S:S680F designated JN.1.36.1 via cov-lineages/pango-designation@dc9f270

@FedeGueli FedeGueli modified the milestones: JN.1.36, JN.1.36 JN.1.36.1 Mar 25, 2024
FedeGueli referenced this issue in cov-lineages/pango-designation Mar 25, 2024
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