In the spirit of Zach Holman's wildly successful AMA, I've decided to do the same. I figure this is a lot easier than trying to monitor some kind of Disqus forum, and since I've been working at GitHub, this should suit us fine.
Asking a question is as easy as creating a new issue on this project. You can also add a label to it depending on the category (I've created some general ones already, so if it doesn't fit into one of those, just leave it blank.
Check out the Closed Issues filter to see what I've answered before. You can also filter by label if you'd like.
If you'd rather just inquire about something in shortform, I'm @mattschaar on Twitter.