A novel meta-heuristic optimization method, namely “Chernobyl Disaster Optimizer (CDO)” is proposed. The underlying concepts and principles behind the proposed approach is inspired by the nuclear reactor core explosion of Chernobyl. In CDO, radioactivity happened because of nuclear instability, which different types of radiations are emitted from nuclei. The most common kinds of these radiations are called gamma, beta, and alpha particles. These particles fly away from the explosion point (high pressure point) to the low pressure point (the human standing point), which are harmful to the humans. The CDO mimics the process of nuclear radiation while attaching human after the nuclear explosion. The main steps of nuclear explosion and attaching human are implemented in which gamma, beta, and alpha particles are involved in this process.