acceleration_phewas

Scripts for UK Biobank accelerometer PheWAS analysis

citation

See Khurshid et al. Accelerometer-Derived and Genetically Inferred Physical Activity and Human Disease. medRxiv 2021. https://doi.org/10.1101/2021.08.05.21261586

overview

• scripts arranged into groups based on functionality
  • phecodes: scripts to generate phecode/outcome tables for association testing
  • seed_files: scripts to generate exposure tables for association testing
  • analysis/analysis: scripts to perform PheWAS analysis (relies on pre-built UK Biobank disease tables, see 'phecodes'), designed to run on outputs of 'phecodes' and 'seed_files'
  • analysis/plotting: scripts to process and visualize association tests
• 'covar' denotes fully adjusted models