Web application: https://synergyfinder.org
Efficient implementations for all the popular synergy scoring models for drug combinations, including HSA, Loewe, Bliss and ZIP and visualization of the synergy scores as either a two-dimensional or a three-dimensional interaction surface over the dose matrix.
If you have any problems in using SynergyFinder, please contact Shuyu Zheng (shuyu.zheng@helsinki.fi) or Jing Tang (jing.tang@helsinki.fi)
Code released under the Mozilla Public License 2.0.
In case you use the package in your work, we do appreciate a citation to our publications:
Zheng S., Wang W., Aldahdooh J., Malyutina A., Shadbahr T., Pessia A., Tang J.* (2022). SynergyFinder Plus: towards a better interpretation and annotation of drug combination screening datasets. Genomics Proteomics Bioinformatics. 20(3):587-596. doi: 10.1016/j.gpb.2022.01.004.
He L., Kulesskiy E, Saarela J., Turunen L., Wennerberg, K., Aittokallio T., Tang J.* (2018) Methods for high-throughput drug combination screening and synergy scoring. Methods Mol Biol. 1711:351-398. doi: 10.1007/978-1-4939-7493-1_17
Ianevski A., He L., Aittokallio T., Tang J.* (2017) SynergyFinder: a web application for analyzing drug combination dose-response matrix data. Bioinformatics 33(15):2413-2415. doi: 10.1093/bioinformatics/btx162