MouseBytes (https://mousebytes.ca/home) is an open-access high-throughput pipeline and database for rodent touchscreen-based cognitive assessment. You can find cognitive behavioral datasets from different animal disease models and cognitive tasks, here. Note that only public datasets in MouseBytes can be shared and re-used under CC0 License.
Each folder belongs to a dataset, and it has its own README file describing metadata associate to all the data files in the dataset. Trial-by-trial data and aggregated data were provided for each dataset in the corresponding folder.
If you are interested in specific data, you can query it using this link: https://mousebytes.ca/data-extraction
This dataset has data files from 5-Choice, Pairwise Visual Discrimination (PVD), and Paired-Associates Learning (PAL) cognitive behavioral tasks in which male and female mice from 3 Alzheimer’s mouse models (3xTG-AD, 5XFAD, APP/PS1) were tested using touchscreen technology at two different sites (e.g. University of Western Ontario and University of Guelph). Both aggregated data and trial-by-trial data are provided in this dataset.
Dataset 2 (Cholinergic-deficient-mouse-model): "Brainstem cholinergic-deficient mouse model (VAChT^En1-Cre-flox/flox) dataset"
Male mice and their wild-type controls were evaluated at 7-10 months of age using the 5-Choice Serial Reaction Time (5-CSRT) task to assess attention. Immediately after (approximately at 9-12 months of age) these same mice were evaluated using the Extinction task to assess their ability to extinguish a response. A different cohort of male mice and their wild-type controls were evaluated at 11-13 months of age in the Pairwise visual discrimination (PVD) task to assess discrimination and reversal learning. Immediately after (still within 11-13 months of age) these same mice were evaluated using the Pairwise Associate Learning (PAL) task to assess learning and memory.
Dataset 3: (Co-transmission-of-cholinergic-interneurons): "Mouse models that differ in neurotransmitter release from striatal cholinergic interneurons"
This dataset has data files from 5-Choice Serial Reaction Time (5-CSRT), Pairwise Visual Discrimination (PVD), and Extinction cognitive behavioral tasks for 4 mouse lines that differ in neurotransmitter release from striatal cholinergic interneurons (ACh or Glu). D2CreVGLUT3fx and ChATIRESVGLUT3fx mice and their wild-type controls were evaluated at 3-7 months of age in the PVD task to assess discrimination and reversal learning. Immediately after (still within 3-7 months of age) these same mice were evaluated using the Extinction task to assess their ability to extinguish a response. D2CreVAChTfx mice and their wild-type controls were evaluated at 5-7 months of age in the 5-CSRT task to assess attention. Immediately after (still within 3-7 months of age) these same mice were evaluated using the Extinction task. VAChTfx control mice that were virally injected with GFP or Cre in the dorsal striatum were evaluated at 6-12 months in the PVD task, followed by the 5-CSRT task (approximately at 8-14 months of age).
Please contact us at mousebytes@uwo.ca if you have any question/concern.
Touchscreen Cognition (https://touchscreencognition.org/) is a virtual space for touchscreen users interested in behavioural testing. If you would like to learn about cognitive behavioral data and touchscreen technology, you can find protocols, training courses, events, and videos tutorials explaining steps of using touchscreen in this website.