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#!/usr/bin/env python | ||
"""Ancestors/Descendants.""" | ||
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import os | ||
import sys | ||
import timeit | ||
import numpy as np | ||
from numpy.random import shuffle | ||
from scipy import stats | ||
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from goatools.base import download_go_basic_obo | ||
from goatools.obo_parser import GODag | ||
from goatools.test_data.godag_timed import prt_hms | ||
from goatools.gosubdag.gosubdag import GoSubDag | ||
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def test_go_pools(): | ||
"""Print a comparison of GO terms from different species in two different comparisons.""" | ||
objr = _Run() | ||
# Check that subset GoSubDags have the same ancestors/descendants as Full GoSubDag | ||
for qty in np.random.randint(10, 100, size=10): | ||
print("") | ||
goids = objr.get_goids_rand(qty) | ||
# No relationships loaded; GoSubDag subset equivalent to Full subset? | ||
gosubdag_r0 = objr.get_gosubdag_r0(goids) | ||
for goid in gosubdag_r0.go2obj: | ||
r0_u = gosubdag_r0.rcntobj.go2parents[goid] | ||
r0_d = gosubdag_r0.rcntobj.go2descendants[goid] | ||
assert r0_u == objr.gosubdag_r0.rcntobj.go2parents[goid] | ||
assert r0_d == objr.gosubdag_r0.rcntobj.go2descendants[goid] | ||
# All relationships loaded; GoSubDag(r0) vs. GoSubDag(r1) | ||
gosubdag_r1 = objr.get_gosubdag_r1(goids) | ||
assert gosubdag_r0.go_sources == gosubdag_r1.go_sources | ||
assert set(gosubdag_r0.go2obj).issubset(gosubdag_r1.go2obj) | ||
cnts = {'r0_u':[], 'r1_u':[], 'r0_d':[], 'r1_d':[]} | ||
for goid in gosubdag_r0.go2obj: | ||
r0_u = gosubdag_r0.rcntobj.go2parents[goid] | ||
r0_d = gosubdag_r0.rcntobj.go2descendants[goid] | ||
r1_u = gosubdag_r1.rcntobj.go2parents[goid] | ||
r1_d = gosubdag_r1.rcntobj.go2descendants[goid] | ||
assert r0_d.issubset(r1_d), "R1({}) R0({})".format(len(r1_d), len(r0_d)) | ||
assert r0_u.issubset(r1_u), "R1({}) R0({})".format(len(r1_u), len(r0_u)) | ||
cnts['r0_u'].append(len(r0_u)) | ||
cnts['r1_u'].append(len(r1_u)) | ||
cnts['r0_d'].append(len(r0_d)) | ||
cnts['r1_d'].append(len(r1_d)) | ||
objr.prt_cnts(cnts) | ||
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class _Run(object): | ||
"""Group entire go-basic.obo""" | ||
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obo = os.path.join(os.path.dirname(os.path.abspath(__file__)), "../../go-basic.obo") | ||
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def __init__(self): | ||
download_go_basic_obo(self.obo, sys.stdout, loading_bar=None) | ||
self.godag_r0 = GODag("go-basic.obo") | ||
self.godag_r1 = GODag("go-basic.obo", optional_attrs=set(['relationship'])) | ||
self.goids = list(set(o.id for o in self.godag_r0.values())) | ||
# GoSubDag (plain) | ||
tic = timeit.default_timer() | ||
self.gosubdag_r0 = GoSubDag(self.goids, self.godag_r0, prt=None) | ||
prt_hms(tic, "GoSubDag r0 {N:4} GOs {S:3} srcs".format( | ||
N=len(self.gosubdag_r0.go2obj), S=len(self.gosubdag_r0.go_sources))) | ||
# GoSubDag with relationships | ||
self.gosubdag_r1 = GoSubDag(self.goids, self.godag_r1, prt=None, relationships=True) | ||
prt_hms(tic, "GoSubDag r1 {N:4} GOs {S:3} srcs".format( | ||
N=len(self.gosubdag_r1.go2obj), S=len(self.gosubdag_r1.go_sources))) | ||
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def prt_cnts(self, cnts): | ||
"""Compare ancestor/descendant counts with relatives=False/True.""" | ||
k2v = {k:self.str_stats(v) for k, v in cnts.items()} | ||
print(k2v) | ||
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@staticmethod | ||
def str_stats(vals): | ||
"""Print statistics on values.""" | ||
ntd = stats.describe(vals) | ||
std = int(round(np.sqrt(ntd.variance))) | ||
return "({m} {M}) STD={STD:,}".format(m=ntd.minmax[0], M=ntd.minmax[1], STD=std) | ||
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def get_gosubdag_r0(self, goids): | ||
"""Return a GoSubDag with N randomly chosen GO sources.""" | ||
tic = timeit.default_timer() | ||
gosubdag = GoSubDag(goids, self.godag_r0, relationships=None, | ||
#rcntobj=self.gosubdag_r0.rcntobj, | ||
prt=None) | ||
prt_hms(tic, "GoSubDag r0 {N:4} GOs {S:3} srcs".format( | ||
N=len(gosubdag.go2obj), S=len(gosubdag.go_sources))) | ||
return gosubdag | ||
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def get_gosubdag_r1(self, goids): | ||
"""Return a GoSubDag with N randomly chosen GO sources.""" | ||
tic = timeit.default_timer() | ||
gosubdag = GoSubDag(goids, self.godag_r1, relationships=True, | ||
#rcntobj=self.gosubdag_r1.rcntobj, | ||
prt=None) | ||
prt_hms(tic, "GoSubDag r1 {N:4} GOs {S:3} srcs".format( | ||
N=len(gosubdag.go2obj), S=len(gosubdag.go_sources))) | ||
return gosubdag | ||
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def get_goids_rand(self, qty): | ||
"""Return N randomly chosen GO IDs.""" | ||
shuffle(self.goids) | ||
return self.goids[:qty] | ||
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if __name__ == '__main__': | ||
test_go_pools() |