Genetic associations at regulatory phenotypes improve fine-mapping of causal variants for twelve immune-mediated diseases

Kousik Kundu^1,2, Manuel Tardaguila¹, Alice L. Mann¹, Stephen Watt¹, Hannes Ponstingl¹, Louella Vasquez¹, Dominique Von Schiller¹, Nicholas W. Morrell³,, Oliver Stegle^4,5, Tomi Pastinen⁶, Stephen J. Sawcer⁷, Carl A. Anderson¹, Klaudia Walter¹, and Nicole Soranzo^1,2,8,9,10*

<sub>1. Human Genetics, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1HH, UK
2. Department of Haematology, University of Cambridge, Cambridge Biomedical Campus, Puddicombe Way, Cambridge CB2 0AW, UK
3. Division of Respiratory Medicine, Department of Medicine, University of Cambridge School of Clinical Medicine, Addenbrooke’s and Papworth Hospitals, Cambridge, United Kingdom
4. European Molecular Biology Laboratory, Genome Biology Unit, 69117 Heidelberg, Germany
5. Division of Computational Genomics and Systems Genetics, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany
6. Genomic Medicine Center, Children’s Mercy Kansas City and Children’s Mercy Research Institute, 2401 Gilham Rd, Kansas City, MO, 64108, USA
7. Department of Clinical Neurosciences, University of Cambridge, BOX 165, Cambridge Biomedical Campus, Hills Road, Cambridge CB2 0QQ, UK
8. British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, UK.
9. National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, Cambridge, UK.
10. Genomics Research Centre, Human Technopole, Milan, Italy.</sub>

All the codes for this study are available here.