Skip to content
New issue

Have a question about this project? Sign up for a free GitHub account to open an issue and contact its maintainers and the community.

By clicking “Sign up for GitHub”, you agree to our terms of service and privacy statement. We’ll occasionally send you account related emails.

Already on GitHub? Sign in to your account

smaller expression value after imputation? #35

Open
chansigit opened this issue Apr 10, 2020 · 0 comments
Open

smaller expression value after imputation? #35

chansigit opened this issue Apr 10, 2020 · 0 comments

Comments

@chansigit
Copy link

Hi,

I ran dca with scanpy and checked the maximum value of the matrix,

np.max(adata_imputed.X)
185.14267

which is even smaller than the original raw counts' maximum

np.max(adata.layers["counts"])
296

How shall I explain such a phenomenon? My personal explanation would be, dca is an AE-based denoiser, not guaranteed to be a missing data imputing tool. Am I right? can you give me more explanation from the AE theoretical principle?

Look forward to your reply. Thanks.

Sign up for free to join this conversation on GitHub. Already have an account? Sign in to comment
Labels
None yet
Projects
None yet
Development

No branches or pull requests

1 participant