The current v1.0 of node-neo4j is pretty functional and feature-complete. You can do most things supported by the Neo4j REST API, including sending custom Cypher queries and Gremlin scripts. We've been using it in production for over a year, and it works just fine.
We will likely give this library a complete overhaul to take full advantage of Neo4j 2.0 features. Since most of those features are in Cypher (or only make sense in practice alongside other actions in a Cypher query), the design will probably emphasize Cypher, potentially even exclusively.