Original Author: Kortine Kleinheinz k.kleinheinz@dkfz-heidelberg.de
Current Author: Gregor Warsow g.warsow@dkfz-heidelberg.de
ACEseq (Allele-specific copy number estimation with whole genome sequencing) is a tool to estimate allele-specific copy numbers from WGS data and comes along with a variety of features:
- GC/replication timing Bias correction
- quality check
- SV breakpoint inclusion
- automated estimation of ploidy and tumor cell content
- HRD/TAI/LST score estimation
- with/without matched control processing
The complete installation instructions can be found in the documentation.
Additional necessary software like e.g. Roddy can be found here
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Kortine Kleinheinz, Isabell Bludau, Daniel Huebschmann, Michael Heinold, Philip Kensche, Zuguang Gu, Cristina Lopez, Michael Hummel, Wolfram Klapper, Peter Moeller, Inga Vater, Rabea Wagener, ICGC MMML-Seq project, Benedikt Brors, Reiner Siebert, Roland Eils, Matthias Schlesner. ACEseq - allele specific copy number estimation from whole genome sequencing. biorxiv.