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Variants causing deletion between two enzymatic cleavage sites #655

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zhuchcn opened this issue Jan 19, 2023 · 1 comment · Fixed by #657
Closed

Variants causing deletion between two enzymatic cleavage sites #655

zhuchcn opened this issue Jan 19, 2023 · 1 comment · Fixed by #657

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@zhuchcn
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zhuchcn commented Jan 19, 2023

For a graph like below, the deletion is causing the peptide LHWSR being lost, which is between two cleavage sites. PVG currently can't tell that MTER is a variant peptide.

MR-GTVALYVDGIGVLYYR-MTER-LHWSR-RN
                   \          /
                    MTER------
@zhuchcn zhuchcn mentioned this issue Jan 20, 2023
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@lydiayliu
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why should MTER be a variant peptide? it will be filtered out from canonical anyways?

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@lydiayliu @zhuchcn