UR-TICS (Unbounded Reactions and Thermodynamic Infeasible Cycles)

Matlab implementation for identifying Unbounded Reactions and Thermodynamically infeasible cycles in Genome-Scale Models of Mycobacterium tuberculosis and Streptomyces clavuligerus Published in:

• López-Agudelo, V. A., Mendum, T. A., Laing, E., Wu, H., Baena, A., Barrera, L. F., ... & Rios-Estepa, R. (2020). A systematic evaluation of Mycobacterium tuberculosis Genome-Scale Metabolic Networks. PLoS computational biology, 16(6), e1007533.(https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1007533)
• Gómez-Ríos, D., López-Agudelo, V. A., Ramírez-Malule, H., Neubauer, P., Junne, S., Ochoa, S., & Ríos-Estepa, R. (2020). A Genome-Scale Insight into the Effect of Shear Stress During the Fed-Batch Production of Clavulanic Acid by Streptomyces Clavuligerus. Microorganisms, 8(9), 1255.(https://www.mdpi.com/2076-2607/8/9/1255)

Dependencies

• Cobra Toolbox 3.0
• Gurobi
• Matlab 2018a