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Convex penalties for the alignment patching #229

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merged 9 commits into from
Mar 23, 2024
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@AndreaGuarracino AndreaGuarracino commented Mar 23, 2024

This PR introduces:

  • convex penalties for the patching
  • mismatch/gap penalties tuning
  • true extension alignment for heat/tail patching
  • trigger patching a bit more often
  • close indel detection during patching (to fix a bit bigger errors). This is triggered not too often as it can be very helpful, but expensive
  • The 1st round of patching is aggressive, and the 2nd round is soft.

We pay in runtime and gain in alignment quality.

@AndreaGuarracino AndreaGuarracino mentioned this pull request Mar 23, 2024
@AndreaGuarracino AndreaGuarracino merged commit d7b6960 into main Mar 23, 2024
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