ASSIGN: Adaptive Signature Selection and InteGratioN
Author: Ying Shen, Andrea H. Bild, David Jenkins, and W. Evan Johnson
ASSIGN is a computational tool to evaluate the pathway deregulation/activation status in individual patient samples. ASSIGN employs a flexible Bayesian factor analysis approach that adapts predetermined pathway signatures derived either from knowledge-based literatures or from perturbation experiments to the cell-/tissue-specific pathway signatures. The deregulation/activation level of each context-specific pathway is quantified to a score, which represents the extent to which a patient sample encompasses the pathway deregulation/activation signature.
ASSIGN is available on Bioconductor:
## try http:// if https:// URLs are not supported source("https://bioconductor.org/biocLite.R") biocLite("ASSIGN")
Or install the development version from github:
# install.packages("devtools") devtools::install_github("wevanjohnson/ASSIGN")