-
Notifications
You must be signed in to change notification settings - Fork 52
/
dat.li2007.html
269 lines (215 loc) · 13.5 KB
/
dat.li2007.html
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
53
54
55
56
57
58
59
60
61
62
63
64
65
66
67
68
69
70
71
72
73
74
75
76
77
78
79
80
81
82
83
84
85
86
87
88
89
90
91
92
93
94
95
96
97
98
99
100
101
102
103
104
105
106
107
108
109
110
111
112
113
114
115
116
117
118
119
120
121
122
123
124
125
126
127
128
129
130
131
132
133
134
135
136
137
138
139
140
141
142
143
144
145
146
147
148
149
150
151
152
153
154
155
156
157
158
159
160
161
162
163
164
165
166
167
168
169
170
171
172
173
174
175
176
177
178
179
180
181
182
183
184
185
186
187
188
189
190
191
192
193
194
195
196
197
198
199
200
201
202
203
204
205
206
207
208
209
210
211
212
213
214
215
216
217
218
219
220
221
222
223
224
225
226
227
228
229
230
231
232
233
234
235
236
237
238
239
240
241
242
243
244
245
246
247
248
249
250
251
252
253
254
255
256
257
258
259
260
261
262
263
264
265
266
267
<!-- Generated by pkgdown: do not edit by hand -->
<!DOCTYPE html>
<html lang="en">
<head>
<meta charset="utf-8">
<meta http-equiv="X-UA-Compatible" content="IE=edge">
<meta name="viewport" content="width=device-width, initial-scale=1.0">
<title>Studies on the Effectiveness of Intravenous Magnesium in Acute Myocardial Infarction — dat.li2007 • metafor</title>
<!-- jquery -->
<script src="https://cdnjs.cloudflare.com/ajax/libs/jquery/3.4.1/jquery.min.js" integrity="sha256-CSXorXvZcTkaix6Yvo6HppcZGetbYMGWSFlBw8HfCJo=" crossorigin="anonymous"></script>
<!-- Bootstrap -->
<link href="https://cdnjs.cloudflare.com/ajax/libs/bootswatch/3.4.0/cosmo/bootstrap.min.css" rel="stylesheet" crossorigin="anonymous" />
<script src="https://cdnjs.cloudflare.com/ajax/libs/twitter-bootstrap/3.4.1/js/bootstrap.min.js" integrity="sha256-nuL8/2cJ5NDSSwnKD8VqreErSWHtnEP9E7AySL+1ev4=" crossorigin="anonymous"></script>
<!-- bootstrap-toc -->
<link rel="stylesheet" href="../bootstrap-toc.css">
<script src="../bootstrap-toc.js"></script>
<!-- Font Awesome icons -->
<link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/all.min.css" integrity="sha256-mmgLkCYLUQbXn0B1SRqzHar6dCnv9oZFPEC1g1cwlkk=" crossorigin="anonymous" />
<link rel="stylesheet" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/5.12.1/css/v4-shims.min.css" integrity="sha256-wZjR52fzng1pJHwx4aV2AO3yyTOXrcDW7jBpJtTwVxw=" crossorigin="anonymous" />
<!-- clipboard.js -->
<script src="https://cdnjs.cloudflare.com/ajax/libs/clipboard.js/2.0.6/clipboard.min.js" integrity="sha256-inc5kl9MA1hkeYUt+EC3BhlIgyp/2jDIyBLS6k3UxPI=" crossorigin="anonymous"></script>
<!-- headroom.js -->
<script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/headroom.min.js" integrity="sha256-AsUX4SJE1+yuDu5+mAVzJbuYNPHj/WroHuZ8Ir/CkE0=" crossorigin="anonymous"></script>
<script src="https://cdnjs.cloudflare.com/ajax/libs/headroom/0.11.0/jQuery.headroom.min.js" integrity="sha256-ZX/yNShbjqsohH1k95liqY9Gd8uOiE1S4vZc+9KQ1K4=" crossorigin="anonymous"></script>
<!-- pkgdown -->
<link href="../pkgdown.css" rel="stylesheet">
<script src="../pkgdown.js"></script>
<meta property="og:title" content="Studies on the Effectiveness of Intravenous Magnesium in Acute Myocardial Infarction — dat.li2007" />
<meta property="og:description" content="Results from 22 trials examining the effectiveness of intravenous magnesium in the prevention of death following acute myocardial infarction." />
<!-- mathjax -->
<script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/MathJax.js" integrity="sha256-nvJJv9wWKEm88qvoQl9ekL2J+k/RWIsaSScxxlsrv8k=" crossorigin="anonymous"></script>
<script src="https://cdnjs.cloudflare.com/ajax/libs/mathjax/2.7.5/config/TeX-AMS-MML_HTMLorMML.js" integrity="sha256-84DKXVJXs0/F8OTMzX4UR909+jtl4G7SPypPavF+GfA=" crossorigin="anonymous"></script>
<!--[if lt IE 9]>
<script src="https://oss.maxcdn.com/html5shiv/3.7.3/html5shiv.min.js"></script>
<script src="https://oss.maxcdn.com/respond/1.4.2/respond.min.js"></script>
<![endif]-->
</head>
<body data-spy="scroll" data-target="#toc">
<div class="container template-reference-topic">
<header>
<div class="navbar navbar-default navbar-fixed-top" role="navigation">
<div class="container">
<div class="navbar-header">
<button type="button" class="navbar-toggle collapsed" data-toggle="collapse" data-target="#navbar" aria-expanded="false">
<span class="sr-only">Toggle navigation</span>
<span class="icon-bar"></span>
<span class="icon-bar"></span>
<span class="icon-bar"></span>
</button>
<span class="navbar-brand">
<a class="navbar-link" href="../index.html">metafor</a>
<span class="version label label-default" data-toggle="tooltip" data-placement="bottom" title="Released version">2.5-50</span>
</span>
</div>
<div id="navbar" class="navbar-collapse collapse">
<ul class="nav navbar-nav">
<li>
<a href="../index.html">
<span class="fa fa-home fa-lg"></span>
</a>
</li>
<li>
<a href="../reference/metafor-package.html">Intro</a>
</li>
<li>
<a href="../reference/index.html">Functions</a>
</li>
<li>
<a href="../articles/pkgdown/diagram.html">Diagram</a>
</li>
<li>
<a href="https://www.jstatsoft.org/index.php/jss/article/view/v036i03/v36i03.pdf">JSS Article (pdf)</a>
</li>
<li>
<a href="../news/index.html">Changelog</a>
</li>
</ul>
<ul class="nav navbar-nav navbar-right">
<li>
<a href="https://twitter.com/wviechtb">
<span class="fa fa-twitter"></span>
</a>
</li>
<li>
<a href="https://github.com/wviechtb/metafor">
<span class="fa fa-github"></span>
</a>
</li>
</ul>
</div><!--/.nav-collapse -->
</div><!--/.container -->
</div><!--/.navbar -->
</header>
<div class="row">
<div class="col-md-9 contents">
<div class="page-header">
<h1>Studies on the Effectiveness of Intravenous Magnesium in Acute Myocardial Infarction</h1>
<div class="hidden name"><code>dat.li2007.Rd</code></div>
</div>
<div class="ref-description">
<p>Results from 22 trials examining the effectiveness of intravenous magnesium in the prevention of death following acute myocardial infarction.</p>
</div>
<pre class="usage"><span class='va'>dat.li2007</span></pre>
<h2 class="hasAnchor" id="format"><a class="anchor" href="#format"></a>Format</h2>
<p>The data frame contains the following columns:</p><table class='table'>
<tr><td><b>id</b></td><td><code>numeric</code></td><td>trial id number</td></tr>
<tr><td><b>study</b></td><td><code>character</code></td><td>first author or trial name</td></tr>
<tr><td><b>year</b></td><td><code>numeric</code></td><td>publication year</td></tr>
<tr><td><b>ai</b></td><td><code>numeric</code></td><td>number of deaths in the magnesium group</td></tr>
<tr><td><b>n1i</b></td><td><code>numeric</code></td><td>number of patients in the magnesium group</td></tr>
<tr><td><b>ci</b></td><td><code>numeric</code></td><td>number of deaths in the control group</td></tr>
<tr><td><b>n2i</b></td><td><code>numeric</code></td><td>number of patients in the control group</td></tr>
</table>
<h2 class="hasAnchor" id="details"><a class="anchor" href="#details"></a>Details</h2>
<p>The dataset includes the results from 22 randomized clinical trials that examined the effectiveness of intravenous magnesium in the prevention of death following acute myocardial infarction. It is similar to the dataset <code><a href='dat.egger2001.html'>dat.egger2001</a></code>, with some slight differences in the included trials and data used.</p>
<h2 class="hasAnchor" id="source"><a class="anchor" href="#source"></a>Source</h2>
<p>Li, J., Zhang, Q., Zhang, M., & Egger, M. (2007). Intravenous magnesium for acute myocardial infarction. <em>Cochrane Database of Systematic Reviews</em>, <b>2</b>, CD002755. <a href='https://doi.org/10.1002/14651858.CD002755.pub2'>https://doi.org/10.1002/14651858.CD002755.pub2</a></p>
<h2 class="hasAnchor" id="see-also"><a class="anchor" href="#see-also"></a>See also</h2>
<div class='dont-index'><p><code><a href='dat.egger2001.html'>dat.egger2001</a></code></p></div>
<h2 class="hasAnchor" id="examples"><a class="anchor" href="#examples"></a>Examples</h2>
<pre class="examples"><div class='input'><span class='co'>### copy data into 'dat' and examine data</span>
<span class='va'>dat</span> <span class='op'><-</span> <span class='va'>dat.li2007</span>
<span class='va'>dat</span>
</div><div class='output co'>#> id study year ai n1i ci n2i
#> 1 1 Morton 1984 1 40 2 36
#> 2 2 Rasmussen 1986 4 56 14 74
#> 3 3 Smith 1986 2 92 7 93
#> 4 4 Abraham 1987 1 48 1 46
#> 5 5 Ceremuzynski 1989 1 25 3 23
#> 6 6 Shechter 1990 1 50 9 53
#> 7 7 Singh 1990 6 81 11 81
#> 8 8 Feldstedt 1991 10 150 8 148
#> 9 9 Shechter 1991 2 21 4 25
#> 10 10 Woods 1992 90 1150 118 1150
#> 11 11 Wu 1992 5 125 12 102
#> 12 12 Thogersen 1995 4 130 8 122
#> 13 13 Shechter 1995 4 96 17 98
#> 14 14 ISIS-4 1995 2216 29011 2103 29039
#> 15 15 Bhargava 1995 3 40 3 38
#> 16 16 Urek 1996 1 31 0 30
#> 17 17 Raghu 1999 6 169 18 181
#> 18 18 MAGIC 2000 475 3113 472 3100
#> 19 19 Gyamlani 2000 2 50 10 50
#> 20 20 Santoro 2000 0 75 1 75
#> 21 21 Zhu 2002 101 1691 134 1488
#> 22 22 Nakashima 2004 1 89 3 91</div><div class='input'>
<span class='co'>### meta-analysis of all trials except ISIS-4</span>
<span class='va'>res</span> <span class='op'><-</span> <span class='fu'><a href='rma.uni.html'>rma</a></span><span class='op'>(</span>measure<span class='op'>=</span><span class='st'>"OR"</span>, ai<span class='op'>=</span><span class='va'>ai</span>, n1i<span class='op'>=</span><span class='va'>n1i</span>, ci<span class='op'>=</span><span class='va'>ci</span>, n2i<span class='op'>=</span><span class='va'>n2i</span>, data<span class='op'>=</span><span class='va'>dat</span>, method<span class='op'>=</span><span class='st'>"FE"</span>, subset<span class='op'>=</span><span class='op'>-</span><span class='fl'>14</span><span class='op'>)</span>
<span class='fu'><a href='https://rdrr.io/r/base/print.html'>print</a></span><span class='op'>(</span><span class='va'>res</span>, digits<span class='op'>=</span><span class='fl'>2</span><span class='op'>)</span>
</div><div class='output co'>#>
#> Fixed-Effects Model (k = 21)
#>
#> I^2 (total heterogeneity / total variability): 51.43%
#> H^2 (total variability / sampling variability): 2.06
#>
#> Test for Heterogeneity:
#> Q(df = 20) = 41.18, p-val < .01
#>
#> Model Results:
#>
#> estimate se zval pval ci.lb ci.ub
#> -0.20 0.05 -3.64 <.01 -0.31 -0.09 ***
#>
#> ---
#> Signif. codes: 0 ‘***’ 0.001 ‘**’ 0.01 ‘*’ 0.05 ‘.’ 0.1 ‘ ’ 1
#> </div><div class='input'><span class='fu'><a href='predict.rma.html'>predict</a></span><span class='op'>(</span><span class='va'>res</span>, transf<span class='op'>=</span><span class='va'>exp</span>, digits<span class='op'>=</span><span class='fl'>2</span><span class='op'>)</span>
</div><div class='output co'>#>
#> pred ci.lb ci.ub
#> 0.82 0.74 0.91
#> </div><div class='input'>
<span class='co'>### meta-analysis of all trials including ISIS-4</span>
<span class='va'>res</span> <span class='op'><-</span> <span class='fu'><a href='rma.uni.html'>rma</a></span><span class='op'>(</span>measure<span class='op'>=</span><span class='st'>"OR"</span>, ai<span class='op'>=</span><span class='va'>ai</span>, n1i<span class='op'>=</span><span class='va'>n1i</span>, ci<span class='op'>=</span><span class='va'>ci</span>, n2i<span class='op'>=</span><span class='va'>n2i</span>, data<span class='op'>=</span><span class='va'>dat</span>, method<span class='op'>=</span><span class='st'>"FE"</span><span class='op'>)</span>
<span class='fu'><a href='https://rdrr.io/r/base/print.html'>print</a></span><span class='op'>(</span><span class='va'>res</span>, digits<span class='op'>=</span><span class='fl'>2</span><span class='op'>)</span>
</div><div class='output co'>#>
#> Fixed-Effects Model (k = 22)
#>
#> I^2 (total heterogeneity / total variability): 63.61%
#> H^2 (total variability / sampling variability): 2.75
#>
#> Test for Heterogeneity:
#> Q(df = 21) = 57.72, p-val < .01
#>
#> Model Results:
#>
#> estimate se zval pval ci.lb ci.ub
#> -0.01 0.03 -0.25 0.80 -0.06 0.05
#>
#> ---
#> Signif. codes: 0 ‘***’ 0.001 ‘**’ 0.01 ‘*’ 0.05 ‘.’ 0.1 ‘ ’ 1
#> </div><div class='input'><span class='fu'><a href='predict.rma.html'>predict</a></span><span class='op'>(</span><span class='va'>res</span>, transf<span class='op'>=</span><span class='va'>exp</span>, digits<span class='op'>=</span><span class='fl'>2</span><span class='op'>)</span>
</div><div class='output co'>#>
#> pred ci.lb ci.ub
#> 0.99 0.94 1.05
#> </div><div class='input'>
<span class='co'>### contour-enhanced funnel plot centered at 0</span>
<span class='fu'><a href='funnel.html'>funnel</a></span><span class='op'>(</span><span class='va'>res</span>, refline<span class='op'>=</span><span class='fl'>0</span>, level<span class='op'>=</span><span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span><span class='fl'>90</span>, <span class='fl'>95</span>, <span class='fl'>99</span><span class='op'>)</span>, shade<span class='op'>=</span><span class='fu'><a href='https://rdrr.io/r/base/c.html'>c</a></span><span class='op'>(</span><span class='st'>"white"</span>, <span class='st'>"gray"</span>, <span class='st'>"darkgray"</span><span class='op'>)</span><span class='op'>)</span>
</div><div class='img'><img src='dat.li2007-1.png' alt='' width='768' height='614' /></div></pre>
</div>
<div class="col-md-3 hidden-xs hidden-sm" id="pkgdown-sidebar">
<nav id="toc" data-toggle="toc" class="sticky-top">
<h2 data-toc-skip>Contents</h2>
</nav>
</div>
</div>
<footer>
<div class="copyright">
<p>Developed by Wolfgang Viechtbauer.</p>
</div>
<div class="pkgdown">
<p>Site built with <a href="https://pkgdown.r-lib.org/">pkgdown</a> 1.6.1.</p>
</div>
</footer>
</div>
</body>
</html>