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yongzhuang committed Jul 17, 2015
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#DNMFilter
#Version 0.1.1

1. Installation
Installation

1) Install Java JDK or JRE;

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4) Install gbm package (http://cran.rproject.org/web/packages/gbm/index.html) in R environment.

2. Running
Running

usage: java -jar DNMFilter.jar <COMMAND> [OPTIONS]

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--cutoff <DOUBLE> cutoff to determine a putative DNM (optional, default 0.4)
--output <FILE> output file (required)

3. File Instruction
File Instruction

1) bam list file (two columns, tab-separated)

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Note the Family ID must be the same as the first column of DNM file and the Individual ID must be the same as the first column of bam list file

4. Others
Others

The package includes a training set built with 264 Epi4k exome trios, which users can employ it to filter new potential DNMs. In addition, the package also includes a feature configuration file.

5. Contact
Contact
yzhuangliu@gmail.com; yongzhuang.liu@hit.edu.cn

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