Introduction

This repository provides R codes for performing Self-Controlled Case Series (SCCS) analysis in a health records database to investigate the association of antidepressants with the risk of dementia.

The general design of the SCCS analysis

Data

The original Data used in the paper is restricted by the ethics of Hospital Authority of Hong Kong. Fictive data is provided instead.

Columns

~ obs_start
~ obs_end
~ first_treatment_start
~ first_treatment_end
~ eventdate
~ case_id
~ sub_treatment_start
~ sub_treatment_end

Example

library(SCCS)
dats <- read.csv('simulated_data.csv',header = TRUE)
dat <- dats
#-----------------------------------
# Multiple exposure types
ageg=c(300,600,900)
con.mod <- standardsccs(event~first_treatment_start+sub_treatment_start+age, indiv=case_id,
                        astart=obs_start, aend=obs_end, aevent=eventdate,
                        adrug =cbind(first_treatment_start,sub_treatment_start),
                        aedrug=cbind(first_treatment_end,sub_treatment_end),
                        expogrp=list(c(-50,1), c(1)), washout=list(c(0,50), c(0)),
                        agegrp=ageg, data=dat)
con.mod

Environment

R (version 3.3.2)
Package "SCCS" (version 1.1)