Companion code (RNA-seq pre-processing, STED image macros, and statistical analyses) to assess the activity of novel small-molecules that target condensates formed by the androgen receptor in prostate cancer cell lines.
Results are summarized in "Rational Optimization of a Transcription Factor Activation Domain Inhibitor" by Basu et al.
Published: Nature Structural & Molecular Biology, Dec 06 2023
DOI: https://doi.org/10.1038/s41594-023-01159-5
R (>= 4.3.0)
Bioconductor (3.17)
STAR aligner (2.7.5a)
RNA-seq data deposited to Gene Expression Omnibus under accession GSE206853
https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE206853
GSEA lists (Human MSigDB Collections: H)
https://data.broadinstitute.org/gsea-msigdb/msigdb/release/7.4/h.all.v7.4.symbols.gmt