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luispedro committed Sep 1, 2020
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_Tobi Olanipekun, Celio Dias Santos Junior and Luis Pedro Coelho_

<div style="padding: 1em" markdown="1">

**Abstract:** When screening publicly available metagenomes for potential AMP
sequences using [Macrel](https://doi.org/10.1101/2019.12.17.880385v4), some of
these sequences were homologous to azuC, a protein without a known biological
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to interact with and modulate membranes. Taken together, we speculate that
besides killing microorganisms, AMPs can evolve into other functions.

</div>

<h2>AzuC was predicted as an AMP</h2>

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expression responding linearly to pressures between 0 MPa to 1 MPa. The same
authors still conclude:

It is tempting to speculate that AzuC was upregulated in response to mild
elevated pressure to maintain membrane stability just like Csps in higher
pressure treatments.
> It is tempting to speculate that AzuC was upregulated in response to mild
> elevated pressure to maintain membrane stability just like Csps in higher
> pressure treatments.
Other authors found azuC over expressed under other stress conditions such as
low pH, heat shock and oxidative stress, although it was regulated under low
Expand Down Expand Up @@ -146,7 +149,8 @@ Guyet A, Dade-Robertson M, Wipat A, Casement J, Smith W, Mitrani H, et al. (2018

<p>Zhang LJ, Gallo RL. Antimicrobial peptides. Curr Biol. 2016;26(1):R14-R19. doi:10.1016/j.cub.2015.11.017</p>

<p>Sharma A, Singla D, Rashid M, Raghava GP. Designing of peptides with desired half-life in intestine-like environment. BMC Bioinformatics. 2014;15(1):282. Published 2014 Aug 20. doi:10.1186/1471-2105-15-282</p>
</p>
<p>Sharma A, Singla D, Rashid M, Raghava GP. Designing of peptides with desired
half-life in intestine-like environment. BMC Bioinformatics. 2014;15(1):282.
Published 2014 Aug 20. doi:10.1186/1471-2105-15-282</p>

</div>

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