Version 1.2.0

What's Changed

• Modified the graph schema adding two new relationship types between genes (imported from Hetionet): geneCovariesWithGene and geneRegulatesGene.
• Updated AlzKB with recent NCBI Gene data (2023-11-09).

Summary of the changes in nodes and relationships

Node (208,436 --> 251,704):

• Gene: 150,045 --> 193,313

Relationship (1,309,466 --> 1,636,739):

• geneCovariesWithGene: 61,606
• geneRegulatesGene: 265,667

The full database dump can be downloaded from the following link:
https://upenn.box.com/s/jmnlcc3zk9yzclky0uv8dd9q7nkxmcgm

Version 1.1.0

What's Changed (Aug 2, 2023)

• Updated the AlzKB with the most recent DrugBank data (V5.1.10 that was released on 2023-01-04) and NCBI Gene data (2023-05-03).
• Upgraded AlzKB to neo4j version 5.

Summary of the changes in nodes and relationships
Node (118,902 --> 208,436):

• Gene: 62407 --> 150045 (geneAssociatesWithDisease doesn't change)
• Drug from drug bank: 13339 --> 15235 (Drug 35063 -->36959)

Relationship (1,309,527 --> 1,309,466):

• bodyPartOverexpressesGene: 97782 --> 97772
• bodyPartUnderexpressesGene: 102194 --> 102185
• geneInPathway: 179464 --> 179433
• geneInteractsWithGene: 147008 --> 147001
• geneParticipatesInBiologicalProcess: 559389 --> 559385

The full database dump can be downloaded from the following link:
https://cedars.box.com/v/epistasislab-alzkb-v1-1-0

AlzKB first DOI release

This is a duplicate of the first release of AlzKB at https://github.com/EpistasisLab/AlzKB/releases/tag/v1.0.0 .

Version 1.0.0

This is our initial release of AlzKB!

The full database dump can be downloaded from the following link:
https://upenn.box.com/s/dalcofa8i7rkkc2h2n6bfg8nvmwi83pq
or
https://cedars.box.com/v/epistasislab-alzkb-v1-0-0

Advanced users have the option of building the database from scratch, although we are still working on finishing the documentation for this procedure..