forked from ITHIM/ITHIM-R
-
Notifications
You must be signed in to change notification settings - Fork 0
/
multi_city_voi.R
1055 lines (844 loc) · 53.7 KB
/
multi_city_voi.R
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
53
54
55
56
57
58
59
60
61
62
63
64
65
66
67
68
69
70
71
72
73
74
75
76
77
78
79
80
81
82
83
84
85
86
87
88
89
90
91
92
93
94
95
96
97
98
99
100
101
102
103
104
105
106
107
108
109
110
111
112
113
114
115
116
117
118
119
120
121
122
123
124
125
126
127
128
129
130
131
132
133
134
135
136
137
138
139
140
141
142
143
144
145
146
147
148
149
150
151
152
153
154
155
156
157
158
159
160
161
162
163
164
165
166
167
168
169
170
171
172
173
174
175
176
177
178
179
180
181
182
183
184
185
186
187
188
189
190
191
192
193
194
195
196
197
198
199
200
201
202
203
204
205
206
207
208
209
210
211
212
213
214
215
216
217
218
219
220
221
222
223
224
225
226
227
228
229
230
231
232
233
234
235
236
237
238
239
240
241
242
243
244
245
246
247
248
249
250
251
252
253
254
255
256
257
258
259
260
261
262
263
264
265
266
267
268
269
270
271
272
273
274
275
276
277
278
279
280
281
282
283
284
285
286
287
288
289
290
291
292
293
294
295
296
297
298
299
300
301
302
303
304
305
306
307
308
309
310
311
312
313
314
315
316
317
318
319
320
321
322
323
324
325
326
327
328
329
330
331
332
333
334
335
336
337
338
339
340
341
342
343
344
345
346
347
348
349
350
351
352
353
354
355
356
357
358
359
360
361
362
363
364
365
366
367
368
369
370
371
372
373
374
375
376
377
378
379
380
381
382
383
384
385
386
387
388
389
390
391
392
393
394
395
396
397
398
399
400
401
402
403
404
405
406
407
408
409
410
411
412
413
414
415
416
417
418
419
420
421
422
423
424
425
426
427
428
429
430
431
432
433
434
435
436
437
438
439
440
441
442
443
444
445
446
447
448
449
450
451
452
453
454
455
456
457
458
459
460
461
462
463
464
465
466
467
468
469
470
471
472
473
474
475
476
477
478
479
480
481
482
483
484
485
486
487
488
489
490
491
492
493
494
495
496
497
498
499
500
501
502
503
504
505
506
507
508
509
510
511
512
513
514
515
516
517
518
519
520
521
522
523
524
525
526
527
528
529
530
531
532
533
534
535
536
537
538
539
540
541
542
543
544
545
546
547
548
549
550
551
552
553
554
555
556
557
558
559
560
561
562
563
564
565
566
567
568
569
570
571
572
573
574
575
576
577
578
579
580
581
582
583
584
585
586
587
588
589
590
591
592
593
594
595
596
597
598
599
600
601
602
603
604
605
606
607
608
609
610
611
612
613
614
615
616
617
618
619
620
621
622
623
624
625
626
627
628
629
630
631
632
633
634
635
636
637
638
639
640
641
642
643
644
645
646
647
648
649
650
651
652
653
654
655
656
657
658
659
660
661
662
663
664
665
666
667
668
669
670
671
672
673
674
675
676
677
678
679
680
681
682
683
684
685
686
687
688
689
690
691
692
693
694
695
696
697
698
699
700
701
702
703
704
705
706
707
708
709
710
711
712
713
714
715
716
717
718
719
720
721
722
723
724
725
726
727
728
729
730
731
732
733
734
735
736
737
738
739
740
741
742
743
744
745
746
747
748
749
750
751
752
753
754
755
756
757
758
759
760
761
762
763
764
765
766
767
768
769
770
771
772
773
774
775
776
777
778
779
780
781
782
783
784
785
786
787
788
789
790
791
792
793
794
795
796
797
798
799
800
801
802
803
804
805
806
807
808
809
810
811
812
813
814
815
816
817
818
819
820
821
822
823
824
825
826
827
828
829
830
831
832
833
834
835
836
837
838
839
840
841
842
843
844
845
846
847
848
849
850
851
852
853
854
855
856
857
858
859
860
861
862
863
864
865
866
867
868
869
870
871
872
873
874
875
876
877
878
879
880
881
882
883
884
885
886
887
888
889
890
891
892
893
894
895
896
897
898
899
900
901
902
903
904
905
906
907
908
909
910
911
912
913
914
915
916
917
918
919
920
921
922
923
924
925
926
927
928
929
930
931
932
933
934
935
936
937
938
939
940
941
942
943
944
945
946
947
948
949
950
951
952
953
954
955
956
957
958
959
960
961
962
963
964
965
966
967
968
969
970
971
972
973
974
975
976
977
978
979
980
981
982
983
984
985
986
987
988
989
990
991
992
993
994
995
996
997
998
999
1000
library(ithimr)
library(earth)
library(RColorBrewer)
library(plotrix)
library(foreach)
library(future)
plan(multisession)
library(doRNG)
library(future.apply)
library(voi) #install_github("chjackson/voi")
library(readxl)
if (!require("drpa",character.only = TRUE)) {
print('Installing "drpa" package...')
remotes::install_github("meta-analyses/drpa")
library(drpa)
print("")
}
rm(list=ls())
# cities <- c('antofagasta', 'arica', 'belo_horizonte', 'bogota', 'buenos_aires',
# 'cali', 'copiapo', 'coquimbo_laserena', 'gran_valparaiso',
# 'iquique_altohospicio', 'medellin', 'mexico_city', 'montevideo',
# 'osorno', 'puerto_montt', 'san_antonio',
# 'santiago', 'sao_paulo', 'temuco_padrelascasas', 'valdivia')
cities <- c('osorno')
# number of times input values are sampled from each input parameter distribution
nsamples <- 2
# list of potential values for the outcome_voi_list
# 'pa_ap_all_cause', 'pa_ap_IHD', 'pa_total_cancer', 'pa_ap_lung_cancer', 'ap_COPD',
# 'pa_ap_stroke', 'pa_ap_T2D', 'ap_LRI', 'pa_breast_cancer', 'pa_colon_cancer', 'pa_endo_cancer',
# 'pa_liver_cancer', 'pa_ap_CVD', 'pa_total_dementia', 'pa_myeloma', 'pa_Parkinson',
# 'pa_head_neck_cancer', 'pa_stomach_cancer', 'inj'
# outcome_voi_list <- c('pa_ap_all_cause', 'pa_ap_IHD', 'pa_total_cancer', 'pa_ap_lung_cancer', 'ap_COPD',
# 'pa_ap_stroke', 'pa_ap_T2D', 'ap_LRI', 'pa_breast_cancer', 'pa_colon_cancer', 'pa_endo_cancer',
# 'pa_liver_cancer', 'pa_ap_CVD', 'pa_total_dementia', 'pa_myeloma', 'pa_Parkinson',
# 'pa_head_neck_cancer', 'pa_stomach_cancer', 'inj')
outcome_voi_list <- c('pa_ap_all_cause')
# flag whether to run VOI analysis split by age and gender as well
voi_age_gender <- T # set to T if want to include split and to F otherwise
# add total across all outputs in VOI list for each scenario - only makes sense if results are independent of each other
# i.e. combining e.g. "total_cancer" with "lung_cancer" results in double-counting and invalid VOI analysis for the sum
voi_add_sum <- T
input_parameter_file <- "InputParameters_v4.0.xlsx"
output_version <- "v0.3" # gives the version number of the output documents, independent of the input parameter file name
author <- "AKS"
comment <- "Added CO2 emission sampling"
# scenario definition
scenario_name <- "GLOBAL"
reference_scenario <- 'Baseline'
compute_mode <- 'sample' # sample from the given input parameter distributions
############################### No need to change the following ##################################
# keep record when code started:
starttime <- Sys.time()
all_inputs <- read_excel(input_parameter_file, sheet = "all_city_parameter_inputs")
all_inputs[is.na(all_inputs)] <- ""
all_inputs <- as.data.frame(all_inputs)
#all_inputs <- read.csv('all_city_parameter_inputs.csv',stringsAsFactors = F) # read in parameter list
# get input parameters into correct format
parameter_names <- all_inputs$parameter
parameter_starts <- which(parameter_names!='')
parameter_stops <- c(parameter_starts[-1] - 1, nrow(all_inputs))
parameter_names <- parameter_names[parameter_names!='']
parameter_list <- list()
for(i in 1:length(parameter_names)){
parameter_list[[parameter_names[i]]] <- list()
parameter_index <- which(all_inputs$parameter==parameter_names[i])
if(all_inputs[parameter_index,2]=='') {
parameter_list[[parameter_names[i]]] <- lapply(cities,function(x) {
city_index <- which(colnames(all_inputs)==x)
val <- all_inputs[parameter_index,city_index]
ifelse(val%in%c('T','F'),val,as.numeric(val))
})
names(parameter_list[[parameter_names[i]]]) <- cities
}else if(all_inputs[parameter_index,2]=='constant'){
if (compute_mode != 'sample'){
indices <- 0
parameter_list[[parameter_names[i]]] <- lapply(cities,function(x) {
city_index <- which(colnames(all_inputs)==x)
val <- all_inputs[parameter_index+indices,city_index]
ifelse(val=='',0,as.numeric(val))
})
}
if(compute_mode=='sample'){ # if sampling from distribution, check that distribution parameters exist
parameter_list[[parameter_names[i]]] <- lapply(cities,function(x) {
indices <- 1:2
city_index <- which(colnames(all_inputs)==x)
val <- all_inputs[parameter_index+indices,city_index]
if (val[1] == '' & val[2]==''){ # if no distribution parameters given in input file, read in constant value instead
indices <-0
city_index <- which(colnames(all_inputs)==x)
val <- all_inputs[parameter_index+indices,city_index]}
val <- as.numeric(val)
})
}
names(parameter_list[[parameter_names[i]]]) <- cities
}else{
parameter_list[[parameter_names[i]]] <- lapply(cities,function(x) {
city_index <- which(colnames(all_inputs)==x)
if(any(all_inputs[parameter_starts[i]:parameter_stops[i],city_index]!='')){
sublist_indices <- which(all_inputs[parameter_starts[i]:parameter_stops[i],city_index]!='')
thing <- as.list(as.numeric(c(all_inputs[parameter_starts[i]:parameter_stops[i],city_index])[sublist_indices]))
names(thing) <- c(all_inputs[parameter_starts[i]:parameter_stops[i],2])[sublist_indices]
thing
}
}
)
names(parameter_list[[parameter_names[i]]]) <- cities
}
}
list2env(parameter_list, environment())
# read in global parameters
all_global_inputs <- read_excel(input_parameter_file, sheet = "all_global_parameter_inputs")
all_global_inputs[is.na(all_global_inputs)] <- ""
all_global_inputs <- as.data.frame(all_global_inputs)
# get input parameters into correct format
global_parameter_names <- all_global_inputs$parameter
global_parameter_starts <- which(global_parameter_names!='')
global_parameter_stops <- c(global_parameter_starts[-1] - 1, nrow(all_global_inputs))
global_parameter_names <- global_parameter_names[global_parameter_names!='']
global_parameter_list <- list()
for(i in 1:length(global_parameter_names)){
global_parameter_list[[global_parameter_names[i]]] <- list()
global_parameter_index <- which(all_global_inputs$parameter==global_parameter_names[i])
if(all_global_inputs[global_parameter_index,2]=='') {
global_parameter_list[[global_parameter_names[i]]] <- all_global_inputs[global_parameter_index,'global']
}else if(all_global_inputs[global_parameter_index,2]=='constant'){
if (compute_mode != 'sample'){
global_parameter_list[[global_parameter_names[i]]] <- ifelse(all_global_inputs[global_parameter_index,'global']=='',
0,as.numeric(all_global_inputs[global_parameter_index,'global']))
}
else if(compute_mode=='sample'){ # if sampling from distribution, check that distribution parameters exist
indices <- 1:2
val <- all_global_inputs[global_parameter_index+indices,'global']
if (val[1] == '' & val[2]==''){ # if no distribution parameters given in input file, read in constant value instead
val <- all_global_inputs[global_parameter_index,'global']}
val <- as.numeric(val)
global_parameter_list[[global_parameter_names[i]]] <- val
}
}
}
list2env(global_parameter_list, environment())
dist_cat <- unlist(strsplit(gsub(" ", "", dist_cat, fixed = TRUE), "\\,"))
outcome_age_min <- as.numeric(unlist(strsplit(gsub(" ", "", outcome_age_min, fixed = TRUE), "\\,")))
outcome_age_max <- as.numeric(unlist(strsplit(gsub(" ", "", outcome_age_max, fixed = TRUE), "\\,")))
outcome_age_groups <- unlist(strsplit(gsub(" ", "", outcome_age_groups, fixed = TRUE), "\\,"))
min_age <- as.numeric(min_age)
max_age <- as.numeric(max_age)
################################### Start running the the actual analysis
## with uncertainty
## comparison across cities
setting_parameters <- c("PM_CONC_BASE","BACKGROUND_PA_SCALAR","BACKGROUND_PA_ZEROS","PM_EMISSION_INVENTORY","CO2_EMISSION_INVENTORY",
"CHRONIC_DISEASE_SCALAR","PM_TRANS_SHARE","INJURY_REPORTING_RATE","BUS_TO_PASSENGER_RATIO", "CAR_OCCUPANCY_RATIO",
"TRUCK_TO_CAR_RATIO", "FLEET_TO_MOTORCYCLE_RATIO","DISTANCE_SCALAR_CAR_TAXI",
"DISTANCE_SCALAR_WALKING", "DISTANCE_SCALAR_PT", "DISTANCE_SCALAR_CYCLING", "DISTANCE_SCALAR_MOTORCYCLE")
# logical for PA dose response: set T for city 1, and reuse values in 2 and 3; no need to recompute
pa_dr_quantile <- c(rep(as.logical(pa_dr_quantile_city1), length(cities)))
# logical for AP dose response: set T for city 1, and reuse values in 2 and 3; no need to recompute
ap_dr_quantile <- c(rep(as.logical(ap_dr_quantile_city1), length(cities)))
betaVariables <- c("PM_TRANS_SHARE",
"INJURY_REPORTING_RATE",
"CASUALTY_EXPONENT_FRACTION",
"BUS_TO_PASSENGER_RATIO",
"CAR_OCCUPANCY_RATIO",
"TRUCK_TO_CAR_RATIO",
"FLEET_TO_MOTORCYCLE_RATIO",
"PROPORTION_MOTORCYCLE_TRIPS",
"CHRONIC_DISEASE_SCALAR",
"SIN_EXPONENT_SUM",
"SIN_EXPONENT_SUM_NOV",
"SIN_EXPONENT_SUM_CYCLE",
"SIN_EXPONENT_SUM_PED",
"SIN_EXPONENT_SUM_VEH")
normVariables <- c("MMET_CYCLING",
"MMET_WALKING",
"PM_CONC_BASE",
"BACKGROUND_PA_SCALAR",
"CASUALTY_EXPONENT_FRACTION",
"CASUALTY_EXPONENT_FRACTION_CYCLE",
"CASUALTY_EXPONENT_FRACTION_PED",
"CASUALTY_EXPONENT_FRACTION_VEH",
"DISTANCE_SCALAR_CAR_TAXI",
"DISTANCE_SCALAR_WALKING",
"DISTANCE_SCALAR_PT",
"DISTANCE_SCALAR_CYCLING",
"DISTANCE_SCALAR_MOTORCYCLE")
save(cities,setting_parameters,injury_reporting_rate,chronic_disease_scalar,pm_conc_base,pm_trans_share,
background_pa_scalar,background_pa_confidence,mmet_cycling,mmet_walking,PM_emission_inventories,CO2_emission_inventories,
sin_exponent_sum,casualty_exponent_fraction, sin_exponent_sum_nov,
sin_exponent_sum_cycle,casualty_exponent_fraction_cycle, sin_exponent_sum_ped,casualty_exponent_fraction_ped,
sin_exponent_sum_veh,casualty_exponent_fraction_veh, pa_dr_quantile,ap_dr_quantile,
bus_to_passenger_ratio,car_occupancy_ratio,truck_to_car_ratio,PM_emission_confidence,CO2_emission_confidence,
distance_scalar_car_taxi,distance_scalar_motorcycle,
distance_scalar_pt,distance_scalar_walking,distance_scalar_cycling,add_motorcycle_fleet,add_personal_motorcycle_trips,
fleet_to_motorcycle_ratio, proportion_motorcycle_trips,
betaVariables,normVariables,file='diagnostic/parameter_settings.Rdata')
#parameters_only <- F
#numcores <- parallel::detectCores() - 1
multi_city_ithim <- outcome <- outcome_pp <- yll_per_hundred_thousand <- list()
print(system.time(
for(ci in 1:length(cities)){
city <- cities[ci]
print(city)
multi_city_ithim[[ci]] <- run_ithim_setup(NSAMPLES = nsamples,
seed=ci,
# from multi city script
DIST_CAT = as.character(dist_cat),
ADD_WALK_TO_PT_TRIPS = as.logical(add_walk_to_pt_trips[[city]]),# originally = F,
CITY=city,
AGE_RANGE = c(min_age,max_age),
ADD_TRUCK_DRIVERS = as.logical(add_truck_drivers),
ADD_BUS_DRIVERS = as.logical(add_bus_drivers),
ADD_CAR_DRIVERS = as.logical(add_car_drivers),
ADD_MOTORCYCLE_FLEET = as.logical(add_motorcycle_fleet[[city]]), #ADD_MOTORCYCLE_FLEET = add_motorcycle_fleet[[city]],
ADD_PERSONAL_MOTORCYCLE_TRIPS = as.character(add_motorcycle_fleet[[city]]),
PM_emission_inventory = PM_emission_inventories[[city]],
CO2_emission_inventory = CO2_emission_inventories[[city]], # added
speeds = speeds[[city]],
FLEET_TO_MOTORCYCLE_RATIO = fleet_to_motorcycle_ratio[[city]],
PROPORTION_MOTORCYCLE_TRIPS = proportion_motorcycle_trips[[city]],
MMET_CYCLING = mmet_cycling,
MMET_WALKING = mmet_walking,
DAY_TO_WEEK_TRAVEL_SCALAR = as.numeric(day_to_week_scalar),
SIN_EXPONENT_SUM = sin_exponent_sum,
CASUALTY_EXPONENT_FRACTION = casualty_exponent_fraction,
SIN_EXPONENT_SUM_NOV = sin_exponent_sum_nov,
SIN_EXPONENT_SUM_CYCLE = sin_exponent_sum_cycle,
CASUALTY_EXPONENT_FRACTION_CYCLE = casualty_exponent_fraction_cycle,
SIN_EXPONENT_SUM_PED = sin_exponent_sum_ped,
CASUALTY_EXPONENT_FRACTION_PED = casualty_exponent_fraction_ped,
SIN_EXPONENT_SUM_VEH = sin_exponent_sum_veh,
CASUALTY_EXPONENT_FRACTION_VEH = casualty_exponent_fraction_veh,
CALL_INDIVIDUAL_SIN = as.logical(call_individual_sin),
CASUALTY_EXPONENT_FRACTION = casualty_exponent_fraction,
PA_DOSE_RESPONSE_QUANTILE = pa_dr_quantile[ci],
AP_DOSE_RESPONSE_QUANTILE = ap_dr_quantile[ci],
INJURY_REPORTING_RATE = injury_reporting_rate[[city]],
CHRONIC_DISEASE_SCALAR = chronic_disease_scalar[[city]],
PM_CONC_BASE = pm_conc_base[[city]],
PM_TRANS_SHARE = pm_trans_share[[city]],
BACKGROUND_PA_SCALAR = background_pa_scalar[[city]],
BUS_WALK_TIME = bus_walk_time[[city]],
RAIL_WALK_TIME = rail_walk_time[[city]],
#additional in VoI script
REFERENCE_SCENARIO= reference_scenario,
BACKGROUND_PA_CONFIDENCE = background_pa_confidence[[city]],
BUS_TO_PASSENGER_RATIO = bus_to_passenger_ratio[[city]],
CAR_OCCUPANCY_RATIO = car_occupancy_ratio[[city]],
TRUCK_TO_CAR_RATIO = truck_to_car_ratio[[city]],
PM_EMISSION_INVENTORY_CONFIDENCE = PM_emission_confidence[[city]],
CO2_EMISSION_INVENTORY_CONFIDENCE = CO2_emission_confidence[[city]],
DISTANCE_SCALAR_CAR_TAXI = distance_scalar_car_taxi[[city]],
DISTANCE_SCALAR_WALKING = distance_scalar_walking[[city]],
DISTANCE_SCALAR_PT = distance_scalar_pt[[city]],
DISTANCE_SCALAR_CYCLING = distance_scalar_cycling[[city]],
DISTANCE_SCALAR_MOTORCYCLE = distance_scalar_motorcycle[[city]],
SCENARIO_NAME = scenario_name)
# for first city, store model parameters. For subsequent cities, copy parameters over.
if(ci==1){
model_parameters <- names(multi_city_ithim[[ci]]$parameters)[!names(multi_city_ithim[[ci]]$parameters)%in%setting_parameters]
parameter_names <- model_parameters[model_parameters!="DR_AP_LIST"]
parameter_samples <- sapply(parameter_names,function(x)multi_city_ithim[[ci]]$parameters[[x]])
}else{
for(param in model_parameters) multi_city_ithim[[ci]]$parameters[[param]] <- multi_city_ithim[[1]]$parameters[[param]]
background_quantile <- plnorm(multi_city_ithim[[1]]$parameters$PM_CONC_BASE,log(pm_conc_base[[1]][1]),log(pm_conc_base[[1]][2]))
multi_city_ithim[[ci]]$parameters$PM_CONC_BASE <- qlnorm(background_quantile,log(pm_conc_base[[city]][1]),log(pm_conc_base[[city]][2]))
proportion_quantile <- pbeta(multi_city_ithim[[1]]$parameters$PM_TRANS_SHARE,pm_trans_share[[1]][1],pm_trans_share[[1]][2])
multi_city_ithim[[ci]]$parameters$PM_TRANS_SHARE <- qbeta(proportion_quantile,pm_trans_share[[city]][1],pm_trans_share[[city]][2])
}
# if(!parameters_only){
# if(Sys.info()[['sysname']] == "Windows"){
# # multi_city_ithim[[ci]]$outcomes <- list()
# require(parallelsugar)
# multi_city_ithim[[ci]]$outcomes <- parallelsugar::mclapply(1:nsamples, FUN = run_ithim, ithim_object = multi_city_ithim[[ci]],mc.cores = numcores)
#
#
# # for(i in 1:nsamples) multi_city_ithim[[ci]]$outcomes[[i]] <- run_ithim(ithim_object = multi_city_ithim[[ci]],seed=i)
# }else{
# multi_city_ithim[[ci]]$outcomes <- mclapply(1:nsamples, FUN = run_ithim, ithim_object = multi_city_ithim[[ci]],mc.cores = numcores)
# }
# multi_city_ithim[[ci]]$DEMOGRAPHIC <- DEMOGRAPHIC
# }
# if(!parameters_only){
multi_city_ithim[[ci]]$outcomes <- list()
doFuture::registerDoFuture()
run_ithm_fn <- function(nsamples, ithim_object,seed, FUN=run_ithim){
foreach(i=1:nsamples, .export = ls(globalenv()) ) %dopar% { #%dorng%
FUN(ithim_object, seed=i)
}
}
multi_city_ithim[[ci]]$outcomes <- run_ithm_fn(nsamples,ithim_object = multi_city_ithim[[ci]], seed)
multi_city_ithim[[ci]]$DEMOGRAPHIC <- DEMOGRAPHIC
# }
## rename city-specific parameters according to city
for(i in 1:length(multi_city_ithim[[ci]]$parameters$PM_EMISSION_INVENTORY[[1]])){
extract_vals <- sapply(multi_city_ithim[[ci]]$parameters$PM_EMISSION_INVENTORY,function(x)x[[i]])
if(sum(extract_vals)!=0)
multi_city_ithim[[ci]]$parameters[[paste0('PM_EMISSION_INVENTORY_',names(multi_city_ithim[[ci]]$parameters$PM_EMISSION_INVENTORY[[1]])[i],'_',city)]] <- extract_vals
}
for(i in 1:length(multi_city_ithim[[ci]]$parameters$CO2_EMISSION_INVENTORY[[1]])){
extract_vals <- sapply(multi_city_ithim[[ci]]$parameters$CO2_EMISSION_INVENTORY,function(x)x[[i]])
if(sum(extract_vals)!=0)
multi_city_ithim[[ci]]$parameters[[paste0('CO2_EMISSION_INVENTORY_',names(multi_city_ithim[[ci]]$parameters$CO2_EMISSION_INVENTORY[[1]])[i],'_',city)]] <- extract_vals
}
for(param in setting_parameters) names(multi_city_ithim[[ci]]$parameters)[which(names(multi_city_ithim[[ci]]$parameters)==param)] <- paste0(param,'_',city)
multi_city_ithim[[ci]]$parameters <- multi_city_ithim[[ci]]$parameters[-which(names(multi_city_ithim[[ci]]$parameters)==paste0('PM_EMISSION_INVENTORY_',city))]
multi_city_ithim[[ci]]$parameters <- multi_city_ithim[[ci]]$parameters[-which(names(multi_city_ithim[[ci]]$parameters)==paste0('CO2_EMISSION_INVENTORY_',city))]
parameter_names_city <- names(multi_city_ithim[[ci]]$parameters)[sapply(names(multi_city_ithim[[ci]]$parameters),function(x)grepl(x,pattern=city))]
## add to parameter names
parameter_names <- c(parameter_names,parameter_names_city)
## get parameter samples and add to array of parameter samples
parameter_samples <- cbind(parameter_samples,sapply(parameter_names_city,function(x)multi_city_ithim[[ci]]$parameters[[x]]))
if(ci>1) multi_city_ithim[[ci]]$parameters <- c()
saveRDS(multi_city_ithim[[ci]],paste0('results/multi_city/',city,'.Rds'))
if(ci>1){
multi_city_ithim[[ci]] <- 0
}else{
multi_city_ithim[[ci]]$outcome <- 0
}
}
))
saveRDS(parameter_samples,'diagnostic/parameter_samples.Rds',version=2)
print('finished ithim-run')
## re-read and extract results #########################################
## set age groups to summarise results across all cities
parameter_samples <- readRDS('diagnostic/parameter_samples.Rds')
# create dataframe containing outcome by age and gender
voi_data_all <- list()
voi_data_all_df <- data.frame()
age_pops <- list()
age_populations <- rep(0,length(outcome_age_groups))
city_populations <- matrix(0,nrow=length(cities),ncol=length(outcome_age_groups))
for(ci in 1:length(cities)){
city <- cities[ci]
multi_city_ithim[[ci]] <- readRDS(paste0('results/multi_city/',city,'.Rds'))
DEMOGRAPHIC <- multi_city_ithim[[ci]]$DEMOGRAPHIC
age_pops[[city]] <- list()
min_pop_ages <- sapply(DEMOGRAPHIC$age,function(x)as.numeric(strsplit(x,'-')[[1]][1]))
max_pop_ages <- sapply(DEMOGRAPHIC$age,function(x)as.numeric(strsplit(x,'-')[[1]][2]))
age_pops[[city]]$min_pop_ages <- min_pop_ages
age_pops[[city]]$max_pop_ages <- max_pop_ages
## get outcomes
min_ages <- sapply(multi_city_ithim[[ci]]$outcomes[[1]]$hb$ylls$age_cat,function(x)as.numeric(strsplit(x,'-')[[1]][1]))
max_ages <- sapply(multi_city_ithim[[ci]]$outcomes[[1]]$hb$ylls$age_cat,function(x)as.numeric(strsplit(x,'-')[[1]][2]))
keep_rows <- which(min_ages>=min_age&max_ages<=max_age)
#keep_cols <- which(!sapply(names(multi_city_ithim[[ci]]$outcomes[[1]]$hb$ylls),function(x)grepl('ac|neo|age|sex',as.character(x))))
keep_cols <- which(!sapply(names(multi_city_ithim[[ci]]$outcomes[[1]]$hb$ylls),function(x)grepl('age|sex',as.character(x))))
#for(i in 1:length(multi_city_ithim[[ci]]$outcomes)) print(length(multi_city_ithim[[ci]]$outcomes[[i]]))
outcome_pp[[city]] <- t(sapply(multi_city_ithim[[ci]]$outcomes, function(x) colSums(x$hb$ylls[keep_rows,keep_cols],na.rm=T)))
outcome_pp[[city]] <- outcome_pp[[city]]/sum(subset(DEMOGRAPHIC,min_pop_ages>=min_age&max_pop_ages<=max_age)$population)
colnames(outcome_pp[[city]]) <- paste0(colnames(outcome_pp[[city]]),'_',city)
## get yll per 100,000 by age
yll_per_hundred_thousand[[city]] <- list()
for(aa in 1:length(outcome_age_groups)){
age <- outcome_age_groups[aa]
city_populations[ci,aa] <- sum(subset(DEMOGRAPHIC,min_pop_ages>=outcome_age_min[aa]&max_pop_ages<=outcome_age_max[aa])$population)
age_populations[aa] <- age_populations[aa] + city_populations[ci,aa]
keep_rows2 <- which(min_ages>=outcome_age_min[aa]&max_ages<=outcome_age_max[aa])
tmp <- t(sapply(multi_city_ithim[[ci]]$outcomes, function(x) colSums(x$hb$ylls[keep_rows2,keep_cols],na.rm=T)))
tmp <- tmp/city_populations[ci,aa]*100000
yll_per_hundred_thousand[[city]][[age]] <- tmp
}
## omit ac (all cause) and neoplasms (neo) and age and gender columns
outcome[[city]] <- t(sapply(multi_city_ithim[[ci]]$outcomes, function(x) colSums(x$hb$ylls[keep_rows,keep_cols],na.rm=T)))
colnames(outcome[[city]]) <- paste0(colnames(outcome[[city]]),'_',city)
for(row in keep_rows){
voi_data_all[[city]]$outcomes <- t(sapply(multi_city_ithim[[ci]]$outcomes, function(x) rbind(x$hb$ylls[row,])))
voi_dummy <- data.frame(voi_data_all[[city]])
colnames(voi_dummy)<-colnames(multi_city_ithim[[ci]]$outcomes[[1]]$hb$ylls)
voi_dummy$city <- city
voi_data_all_df <- rbind(voi_data_all_df, voi_dummy)
}
#voi_data_all_df$city <- city
multi_city_ithim[[ci]] <- 0
}
voi_data_all_df$age_sex <- paste(voi_data_all_df$sex, voi_data_all_df$age_cat, sep = )
## gather results ###############################################
NSCEN <- ncol(outcome[[1]])/sum(sapply(colnames(outcome[[1]]),function(x)grepl('scen1',x)))
SCEN_SHORT_NAME <- c('baseline',sapply(colnames(outcome[[1]])[1:NSCEN],function(x)strsplit(x,'_')[[1]][1]))
NSAMPLES <- nrow(outcome[[1]])
## compute and save yll per hundred thousand by age
saveRDS(yll_per_hundred_thousand,'results/multi_city/yll_per_hundred_thousand.Rds',version=2)
yll_per_hundred_thousand_results <- list()
combined_yll <- list()
for(aa in 1:length(outcome_age_groups)){
age <- outcome_age_groups[aa]
combined_yll[[age]] <- matrix(0,ncol=NSCEN,nrow=NSAMPLES)
}
for(ci in 1:length(cities)){
city <- cities[ci]
case <- yll_per_hundred_thousand[[city]]
yll_per_hundred_thousand_results[[city]] <- list()
for(aa in 1:length(outcome_age_groups)){
age <- outcome_age_groups[aa]
min_pop_ages <- age_pops[[city]]$min_pop_ages
max_pop_ages <- age_pops[[city]]$max_pop_ages
population <- city_populations[ci,aa]
yll_per_hundred_thousand_results[[city]][[age]] <- matrix(0,nrow=NSCEN,ncol=3)#(median=numeric(),'5%'=numeric(),'95%'=numeric())
colnames(yll_per_hundred_thousand_results[[city]][[age]]) <- c('median','5%','95%')
rownames(yll_per_hundred_thousand_results[[city]][[age]]) <- SCEN_SHORT_NAME[2:length(SCEN_SHORT_NAME)]
case_age <- case[[age]]
for(k in 1:NSCEN){
scen_case <- case_age[,seq(k,ncol(case_age),by=NSCEN)]
if(nsamples==1){ # if only one sample, then scen_case gives a 1 dimensional vector
y <- sum(scen_case)
}else{
y <- rowSums(scen_case)
}
yll_per_hundred_thousand_results[[city]][[age]][k,] <- quantile(y,c(0.5,0.05,0.95))
combined_yll[[age]][,k] <- combined_yll[[age]][,k] + y*population/100000
}
}
}
yll_per_hundred_thousand_results$combined <- list()
for(aa in 1:length(outcome_age_groups)){
age <- outcome_age_groups[aa]
yll_per_hundred_thousand_results$combined[[age]] <- t(apply(combined_yll[[age]]/age_populations[aa]*100000,2,quantile,c(0.5,0.05,0.95)))
colnames(yll_per_hundred_thousand_results$combined[[age]]) <- c('median','5%','95%')
rownames(yll_per_hundred_thousand_results$combined[[age]]) <- SCEN_SHORT_NAME[2:length(SCEN_SHORT_NAME)]
}
saveRDS(yll_per_hundred_thousand_results,'results/multi_city/yll_per_hundred_thousand_quantiles.Rds',version=2)
for(i in 1:length(yll_per_hundred_thousand_results))
for(j in 1:length(yll_per_hundred_thousand_results[[i]]))
write.csv(yll_per_hundred_thousand_results[[i]][[j]],
paste0('results/multi_city/yll_per_hundred_thousand/',names(yll_per_hundred_thousand_results)[i],
names(yll_per_hundred_thousand_results[[i]])[j],'_',output_version,'.csv'))
for(i in 1:length(outcome_pp)){
outcome_pp_quantile <- matrix(0,nrow=NSCEN,ncol=3)#(median=numeric(),'5%'=numeric(),'95%'=numeric())
colnames(outcome_pp_quantile) <- c('median','5%','95%')
rownames(outcome_pp_quantile) <- SCEN_SHORT_NAME[2:length(SCEN_SHORT_NAME)]
for(k in 1:NSCEN){
scen_case <- outcome_pp[[i]][,seq(k,ncol(outcome_pp[[i]]),by=NSCEN)]
if (nsamples==1){
y <- sum(scen_case)*100000
}else{
y <- rowSums(scen_case)*100000
}
outcome_pp_quantile[k,] <- quantile(y,c(0.5,0.05,0.95))
}
#write.csv(outcome_pp_quantile,paste0('results/multi_city/yll_per_hundred_thousand/',cities[i],'.csv'))
}
outcomes_pp <- do.call(cbind,outcome_pp)
outcome$combined <- outcomes_pp
saveRDS(outcome,'results/multi_city/outcome.Rds',version=2)
######################################################### plot results #######################################################
print('plot results')
# plots only work if more than one sample was selected
if(nsamples > 1){
{pdf(paste0('results/multi_city/city_yll_',output_version,'.pdf'),height=6,width=6)
# one plot for all cities - might be difficult to read
par <- par(mar=c(5,5,1,1))
sp_index <- which(cities==city)
scen_out <- lapply(outcome[-length(outcome)],function(x)sapply(1:NSCEN,function(y)rowSums(x[,seq(y,ncol(x),by=NSCEN)])))
means <- sapply(scen_out,function(x)apply(x,2,mean))
ninefive <- lapply(scen_out,function(x) apply(x,2,quantile,c(0.05,0.95)))
yvals <- rep(1:length(scen_out),each=NSCEN)/10 + rep(1:NSCEN,times=length(scen_out))
cols <- rainbow(length(outcome)-1)
plot(as.vector(means),yvals,pch=16,cex=1,frame=F,ylab='',xlab='Change in YLL relative to baseline',
col=rep(cols,each=NSCEN),yaxt='n',xlim=range(unlist(ninefive)))
axis(2,las=2,at=(1+0.1):(NSCEN+0.1),labels=SCEN_SHORT_NAME[2:length(SCEN_SHORT_NAME)])
for(i in 1:length(outcome[-length(outcome)])) for(j in 1:NSCEN) lines(ninefive[[i]][,j],rep(yvals[j+(i-1)*NSCEN],2),lwd=2,col=cols[i])
abline(v=0,col='grey',lty=2,lwd=2)
text(y=(NSCEN-1)+0.2,x=ninefive[[sp_index]][1,(NSCEN-1)],'90%',col='navyblue',adj=c(-0,-0.3*sp_index))
legend(col=rev(cols),lty=1,bty='n',x= mean(means),legend=rev(names(outcome)[-length(outcome)]),y=NSCEN-1,lwd=2)
par(par)
for(city in cities){ # one plot per city
sp_index <- which(cities==city)
scen_out <- lapply(outcome[-length(outcome)],function(x)sapply(1:NSCEN,function(y)rowSums(x[,seq(y,ncol(x),by=NSCEN)])))
scen_out_city <- scen_out[[city]]
means <- colMeans(scen_out_city) #sapply(scen_out_city,function(x)apply(x,2,mean))
ninefive <- apply(scen_out_city,2,quantile,probs = c(0.05,0.95))
yvals <- rep(1,each=NSCEN)/10 + rep(1:NSCEN) #rep(1:length(scen_out_city),each=NSCEN)/10 + rep(1:NSCEN,times=length(scen_out_city))
cols <- rainbow(length(outcome)-1)
col_city <- cols[sp_index]
par_city <- par(mar=c(5,5,1,1))
xlab <- paste0(city,': Change in YLL relative to baseline')
plot(as.vector(means),yvals,pch=16,cex=1,frame=F,ylab='',xlab=xlab,col=rep(col_city,each=NSCEN),
yaxt='n',xlim=range(unlist(ninefive)))
axis(2,las=2,at=(1+0.1):(NSCEN+0.1),labels=SCEN_SHORT_NAME[2:length(SCEN_SHORT_NAME)])
#for(i in 1:length(outcome[-length(outcome)])) for(j in 1:NSCEN) lines(ninefive[[i]][,j],rep(yvals[j+(i-1)*NSCEN],2),lwd=2,col=cols[i])
for(j in 1:NSCEN) lines(ninefive[,j],rep(yvals[j],2),lwd=2,col=col_city)
abline(v=0,col='grey',lty=2,lwd=2)
text(y=(NSCEN-1)+0.2,x=ninefive[1,(NSCEN-1)],'90%',col='navyblue',adj=c(-0,-0.3*sp_index))
legend(col=col_city, lty=1,bty='n',x= mean(means),legend=city,y=NSCEN-1,lwd=2)
par(par_city)
}
dev.off()
}
# plotting the output as sums across all cities
comb_out <- sapply(1:NSCEN,function(y)rowSums(outcome[[length(outcome)]][,seq(y,ncol(outcome[[length(outcome)]]),by=NSCEN)]))
ninefive <- apply(comb_out,2,quantile,c(0.05,0.95))
means <- apply(comb_out,2,mean)
{pdf(paste0('results/multi_city/combined_yll_pp','_',output_version,'.pdf'),height=3,width=6); par(mar=c(5,5,1,1))
plot(as.vector(means),1:NSCEN,pch=16,cex=1,frame=F,ylab='',xlab='Change in YLL pp relative to baseline',col='navyblue',yaxt='n',xlim=range(ninefive))
axis(2,las=2,at=1:NSCEN,labels=SCEN_SHORT_NAME[2:length(SCEN_SHORT_NAME)])
for(j in 1:NSCEN) lines(ninefive[,j],c(j,j),lwd=2,col='navyblue')
abline(v=0,col='grey',lty=2,lwd=2)
text(y=(NSCEN-1),x=ninefive[1,(NSCEN-1)],'90%',col='navyblue',adj=c(-0,-0.7))
dev.off()
}
}
################################################ calculate EVPPI ################################################
print('start EVPPI analysis')
if (nsamples > 1){ # only run EVPPI part if more than one sample was selected
# first extract input parameters of interest
# create list with global parameters
general_inputs <- sapply(colnames(parameter_samples),function(x)!grepl(paste(cities, collapse = "|"),x))
general_parsampl <- parameter_samples[,general_inputs]
# remove alpha, beta, gamma and tmrel dose response parameters as they are not independent of each other
general_noDRpara <- sapply(colnames(general_parsampl), function(x)!grepl(paste(c('ALPHA','BETA','GAMMA','TMREL'),
collapse = "|"),x))
general_noDRpara_parsampl <- general_parsampl[,general_noDRpara]
evppi_df <- data.frame()
for (city in cities){
# extract city specific input parameters
city_inputs <- sapply(colnames(parameter_samples),function(x)grepl(city,x))
city_parsampl <- parameter_samples[,city_inputs]
# remove CO2 parameters
city_noCO2para <- sapply(colnames(city_parsampl), function(x)!grepl('CO2',x))
city_parsampl <- city_parsampl[,city_noCO2para]
# extract the required outcomes for each city
city_out <- as.data.frame(outcome[[city]])
city_outputs <- sapply(colnames(city_out),function(x)grepl(paste(outcome_voi_list, collapse = "|"),x))
city_outcomes <- city_out[,city_outputs]
if(voi_add_sum){
# add total result for each scenario - only makes sense if results are independent of each other
# i.e. combining e.g. "total_cancer" with "lung_cancer" results in double-counting and invalid VOI analysis for the sum
for (n in 1:NSCEN){
scen_outputs <- sapply(colnames(city_outcomes), function(x)grepl(paste0("scen",n),x))
if (length(outcome_voi_list) == 1){
city_outcomes[paste0('scen',n,"_ylls_sum_",city)] <- city_outcomes[,scen_outputs]
} else{
city_outcomes[paste0('scen',n,"_ylls_sum_",city)] <- rowSums(city_outcomes[,scen_outputs])
}
}
}
param_no <- ncol(city_parsampl) + ncol(general_noDRpara_parsampl)
evppi_city <- future_lapply(1:param_no, # calculate the evppi for each city
FUN = ithimr::compute_evppi,
global_para = as.data.frame(general_noDRpara_parsampl),
city_para = as.data.frame(city_parsampl),
city_outcomes = city_outcomes,
nsamples = NSAMPLES)
# evppi_city <- future_lapply(1:param_no, # calculate the evppi for each city
# FUN = compute_evppi,
# global_para = as.data.frame(general_noDRpara_parsampl),
# city_para = as.data.frame(city_parsampl),
# city_outcomes = city_outcomes,
# nsamples = NSAMPLES)
#
evppi_city2 <- do.call(rbind,evppi_city)
evppi_city3 <- as.data.frame(evppi_city2) # turn into dataframe
evppi_outcome_names <- strsplit(colnames(city_outcomes),paste("_",city,sep="")) # add column names without city part
colnames(evppi_city3) <- evppi_outcome_names
evppi_outcome_names <- colnames(evppi_city3)
evppi_city3$parameters <- c(colnames(general_noDRpara_parsampl), colnames(city_parsampl)) # add parameter name column
evppi_city3$city <- city # add city name column
# look at dose response input parameters separately, as alpha, beta, gammy and trmel are dependent on each other
if(any(ap_dr_quantile)&&NSAMPLES>=300){
AP_names <- sapply(colnames(parameter_samples),function(x)length(strsplit(x,'AP_DOSE_RESPONSE_QUANTILE_ALPHA')[[1]])>1)
diseases <- sapply(colnames(parameter_samples)[AP_names],function(x)strsplit(x,'AP_DOSE_RESPONSE_QUANTILE_ALPHA_')[[1]][2])
sources <- list()
for(di in diseases){
col_names <- sapply(colnames(parameter_samples),function(x)grepl('AP_DOSE_RESPONSE_QUANTILE',x)&grepl(di,x))
sources[[di]] <- parameter_samples[,col_names]
}
evppi_for_AP_city <- future_lapply(1:length(sources),
FUN = ithimr:::compute_evppi,
global_para = sources,
city_para = data.frame(),
city_outcomes = city_outcomes,
nsamples = NSAMPLES)
evppi_for_AP_city2 <- do.call(rbind,evppi_for_AP_city)
evppi_for_AP_city3 <- as.data.frame(evppi_for_AP_city2) # turn into dataframe
colnames(evppi_for_AP_city3) <- evppi_outcome_names
evppi_for_AP_city3$parameters <- c(paste0('AP_DOSE_RESPONSE_QUANTILE_',diseases)) # add parameter name column
evppi_for_AP_city3$city <- city # add city name column
evppi_city3 <- rbind(evppi_city3, evppi_for_AP_city3)
}
evppi_df <- rbind(evppi_df, evppi_city3) # add to total evppi dataframe
} # end of city loop
evppi_df <- evppi_df %>% relocate(city,parameters) # change order of columns
saveRDS(evppi_df,'results/multi_city/evppi.Rds',version=2) # save evppi dataframe
evppi_csv <- paste0('results/multi_city/evppi_',output_version,".csv")
#write.csv(evppi_df,'results/multi_city/evppi.csv',row.names = FALSE) # save as csv file
write.csv(evppi_df,evppi_csv,row.names = FALSE) # save as csv file
# add to output control document
timestamp <- Sys.time()
input_version <- input_parameter_file
global_path <- paste0(file.path(find.package('ithimr',lib.loc = .libPaths()),
'extdata/global'), "/")
cat("",
paste(timestamp, "by", author, sep = " "),
paste("Cities:", cities, sep = " "),
paste("Input parameter file:", input_version, sep = " "),
paste("Version number of outputs:", output_version, sep = " "),
paste("Number of samples:", nsamples, sep = " "),
paste("Comments:", comment, sep=" "),
paste("Path of other input files:", global_path, sep=" "),
file="OutputVersionControl.txt",sep="\n",append=TRUE)
# create output plots
output_pdf <- paste0('results/multi_city/evppi_',output_version,".pdf")
#{pdf('results/multi_city/evppi.pdf',height=15,width=4+length(outcome_voi_list))
{pdf(output_pdf,height=15,width=4+length(outcome_voi_list)+1)
for ( city_name in cities){
evppi_city_df <- evppi_df %>% filter(city == city_name)
par_city <- par(mar=c(10,13,4,3.5))
labs <- evppi_city_df$parameters # y axis label
labs <- str_replace(labs,'DOSE_RESPONSE','DR') # replace DOSE_RESPONSE with DR
labs <- str_replace(labs,'EMISSION_INVENTORY','EMISSION_INV') # replace EMISSION_INVENTORY with EMISSION_INV
evppi_dummy <- evppi_city_df[,evppi_outcome_names]
# for plotting purposes, replace all NaN with 0
evppi_dummy[is.na(evppi_dummy)] <- 0
get.pal=colorRampPalette(brewer.pal(9,"Reds"))
redCol=rev(get.pal(12))
bkT <- seq(max(evppi_dummy[!is.na(evppi_dummy)])+1e-10, 0,length=13)
cex.lab <- 1.0
maxval <- round(bkT[1],digits=1)
col.labels<- c(0,maxval/2,maxval)
cellcolors <- vector()
title <- paste(city_name, " - No of samples: ", nsamples,
# ': By how much (%) could we\n reduce uncertainty in the outcome\n if we knew this parameter perfectly?')
'- By how much (%) could we reduce\n uncertainty in the outcome if we knew this parameter perfectly?')
for(ii in 1:length(unlist(evppi_dummy))) # determine the cellcolors
cellcolors[ii] <- redCol[tail(which(unlist(evppi_dummy)[ii]<bkT),n=1)]
color2D.matplot(evppi_dummy,cellcolors=cellcolors,xlab="",ylab="",axes=F,border='white')
title(title, adj = 0, cex.main = 0.7 )
fullaxis(side=1,at=(ncol(evppi_dummy)-1):0+0.5,labels=rev(colnames(evppi_dummy)),
las = 2, line=NA,pos=NA,outer=FALSE,font=NA,lwd=0,cex.axis=0.65) # x-axis labels
fullaxis(side=2,las=1,at=(length(labs)-1):0+0.5,labels=labs,
line=NA,pos=NA,outer=FALSE,font=NA,lwd=0,cex.axis=0.6) # y-axis labels
color.legend(ncol(evppi_dummy)+0.5,0,ncol(evppi_dummy)+1.2,length(labs),col.labels,rev(redCol),
gradient="y",cex=0.7,align="rb")
for(i in seq(0,ncol(evppi_dummy),by=NSCEN)) abline(v=i, lwd=2) # add vertical lines
for(i in c(0,length(labs))) abline(h=i, lwd = 2) # add horizontal lines at top and bottom
par(par_city)
}
dev.off()}
##### run EVPPI for different age groups and gender
if(voi_age_gender){
print('starting EVPPI analysis by age and sex')
evppi_agesex_df <- data.frame()
for (city in cities){
print(city)
# extract city specific input parameters
city_inputs <- sapply(colnames(parameter_samples),function(x)grepl(city,x))
city_parsampl <- parameter_samples[,city_inputs]
param_no <- ncol(city_parsampl) + ncol(general_noDRpara_parsampl)
# extract the required outcomes for each city - loop through age and gender categories
city_name <- city
city_agesex_out <- voi_data_all_df %>% filter(city == city_name)
age_gender_cat <- unique(city_agesex_out$age_sex)
k <- 1
for(age_gender in age_gender_cat){
city_agesex_out2 <- city_agesex_out %>% filter(age_sex == age_gender)
city_agesex_outputs <- sapply(colnames(city_agesex_out2),function(x)grepl(paste(outcome_voi_list, collapse = "|"),x))
city_agesex_outcomes <- city_agesex_out2[,city_agesex_outputs]
if(voi_add_sum){
# add total result for each scenario - only makes sense if results are independent of each other
# i.e. combining e.g. "total_cancer" with "lung_cancer" results in double-counting and invalid VOI analysis for the sum
for (n in 1:NSCEN){
scen_outputs <- sapply(colnames(city_agesex_outcomes), function(x)grepl(paste0("scen",n),x))
if (length(outcome_voi_list) == 1){
city_agesex_outcomes[paste0('scen',n,"_ylls_sum_",city)] <- sapply(city_agesex_outcomes[,scen_outputs], unlist)
} else{
city_agesex_outcomes[paste0('scen',n,"_ylls_sum_",city)] <- rowSums(sapply(city_agesex_outcomes[,scen_outputs], unlist))
}
}
}
# replace NA with 0s, note that the evppi analysis returns NA for all outcomes that are all 0
city_agesex_outcomes_na_cols <- names(which(colSums(is.na(city_agesex_outcomes))>0)) # record colnames
city_agesex_outcomes[is.na(city_agesex_outcomes)] <- 0 # replace NAs with 0
# calculate evppi
evppi_agesex_city <- future_lapply(1:param_no, # calculate the evppi for each city
FUN = ithimr::compute_evppi,
global_para = as.data.frame(general_noDRpara_parsampl),
city_para = as.data.frame(city_parsampl),
city_outcomes = city_agesex_outcomes,
nsamples = NSAMPLES)
evppi_agesex_city2 <- do.call(rbind,evppi_agesex_city)
evppi_agesex_city3 <- as.data.frame(evppi_agesex_city2) # turn into dataframe
evppi_agesex_outcome_names <- strsplit(colnames(city_agesex_outcomes),paste("_",city,sep="")) # add column names without city part
colnames(evppi_agesex_city3) <- paste(evppi_agesex_outcome_names, age_gender, sep = "_")
evppi_agesex_outcome_names <- colnames(evppi_agesex_city3)
# replace columns for which the outcomes where originally NA by NA again
if (length(city_agesex_outcomes_na_cols)>0){
city_agesex_outcomes_na_cols2 <- strsplit(city_agesex_outcomes_na_cols,paste("_",city,sep=""))
city_agesex_outcomes_na_cols3 <- paste(city_agesex_outcomes_na_cols2,age_gender, sep = "_")
evppi_agesex_city3[,city_agesex_outcomes_na_cols3] <- NaN
}
if(k == 1){
evppi_agesex_city_df <- evppi_agesex_city3
}else{evppi_agesex_city_df <- cbind(evppi_agesex_city_df, evppi_agesex_city3)}
k <- k + 1
}
evppi_agesex_city_df$parameters <- c(colnames(general_noDRpara_parsampl), colnames(city_parsampl)) # add parameter name column
evppi_agesex_city_df$city <- city # add city name column
# look at dose response input parameters separately, as alpha, beta, gammy and trmel are dependent on each other
if(any(ap_dr_quantile)&&NSAMPLES>=300){
AP_names <- sapply(colnames(parameter_samples),function(x)length(strsplit(x,'AP_DOSE_RESPONSE_QUANTILE_ALPHA')[[1]])>1)
diseases <- sapply(colnames(parameter_samples)[AP_names],function(x)strsplit(x,'AP_DOSE_RESPONSE_QUANTILE_ALPHA_')[[1]][2])
sources <- list()
for(di in diseases){
col_names <- sapply(colnames(parameter_samples),function(x)grepl('AP_DOSE_RESPONSE_QUANTILE',x)&grepl(di,x))
sources[[di]] <- parameter_samples[,col_names]
}
k <- 1
for(age_gender in age_gender_cat){
city_agesex_out2 <- city_agesex_out %>% filter(age_sex == age_gender)
city_agesex_outputs <- sapply(colnames(city_agesex_out2),function(x)grepl(paste(outcome_voi_list, collapse = "|"),x))
city_agesex_outcomes <- city_agesex_out2[,city_agesex_outputs]
if(voi_add_sum){
# add total result for each scenario - only makes sense if results are independent of each other
# i.e. combining e.g. "total_cancer" with "lung_cancer" results in double-counting and invalid VOI analysis for the sum
for (n in 1:NSCEN){
scen_outputs <- sapply(colnames(city_agesex_outcomes), function(x)grepl(paste0("scen",n),x))
if (length(outcome_voi_list) == 1){
city_agesex_outcomes[paste0('scen',n,"_ylls_sum_",city)] <- sapply(city_agesex_outcomes[,scen_outputs], unlist)
} else{
city_agesex_outcomes[paste0('scen',n,"_ylls_sum_",city)] <- rowSums(sapply(city_agesex_outcomes[,scen_outputs], unlist))
}
}
}
# replace NA with 0s, note that the evppi analysis returns NA for all outcomes that are all 0
city_agesex_outcomes_na_cols <- names(which(colSums(is.na(city_agesex_outcomes))>0)) # record colnames
city_agesex_outcomes[is.na(city_agesex_outcomes)] <- 0 # replace NAs with 0
evppi_agesex_for_AP_city <- future_lapply(1:length(sources),
FUN = ithimr:::compute_evppi,
global_para = sources,
city_para = data.frame(),
city_outcomes = city_agesex_outcomes,
nsamples = NSAMPLES)
evppi_agesex_for_AP_city2 <- do.call(rbind,evppi_agesex_for_AP_city)
evppi_agesex_for_AP_city3 <- as.data.frame(evppi_agesex_for_AP_city2) # turn into dataframe
evppi_agesex_AP_outcome_names <- strsplit(colnames(city_agesex_outcomes),paste("_",city,sep="")) # add column names without city part
colnames(evppi_agesex_for_AP_city3) <- paste(evppi_agesex_AP_outcome_names, age_gender, sep = "_")
#evppi_agesex_AP_outcome_names <- colnames(evppi_agesex_for_AP_city3)
# replace columns for which the outcomes where originally NA by NA again
if (length(city_agesex_outcomes_na_cols)>0){
city_agesex_outcomes_na_cols2 <- strsplit(city_agesex_outcomes_na_cols,paste("_",city,sep=""))
city_agesex_outcomes_na_cols3 <- paste(city_agesex_outcomes_na_cols2,age_gender, sep = "_")
evppi_agesex_for_AP_city3[,city_agesex_outcomes_na_cols3] <- NaN
}
if(k == 1){
evppi_agesex_ap_city_df <- evppi_agesex_for_AP_city3
} else{
evppi_agesex_ap_city_df <- cbind(evppi_agesex_ap_city_df, evppi_agesex_for_AP_city3)
}
k <- k + 1
}
evppi_agesex_ap_city_df$parameters <- c(paste0('AP_DOSE_RESPONSE_QUANTILE_',diseases)) # add parameter name column
evppi_agesex_ap_city_df$city <- city # add city name column
evppi_agesex_city_df <- rbind(evppi_agesex_city_df, evppi_agesex_ap_city_df)
}
# change structure of evppi_agesex_city_df to make it more flexible when different age categories are used for different cities
# create one df for each city
assign(paste0("evppi_agesex_",city_name,'_df'), evppi_agesex_city_df)
evppi_agesex_city_df_rearranged <- data.frame()
k <- 1
for (ag in age_gender_cat){
ag_colnames <- sapply(colnames(evppi_agesex_city_df),function(x)grepl(paste0("_",ag),x)) # find column names depending on age and gender
ag_columns_df <- evppi_agesex_city_df[,ag_colnames] # only keep those columns that are dependent on age and gender
new_col_names <- sapply(colnames(ag_columns_df),function(x)strsplit(x,paste0('_',ag))[[1]]) # remove age and gender part from those columns
colnames(ag_columns_df) = new_col_names
ag_columns_df$parameters <- evppi_agesex_city_df$parameters
ag_columns_df$city <- evppi_agesex_city_df$city
ag_columns_df$gender <- strsplit(ag, " ")[[1]][1]
ag_columns_df$age <- strsplit(ag, " ")[[1]][2]
ag_columns_df$age_gender <- ag
if (k == 1){
evppi_agesex_city_df_rearranged <- ag_columns_df
}else{
evppi_agesex_city_df_rearranged <- rbind(evppi_agesex_city_df_rearranged, ag_columns_df)
}
k <- k +1
}
evppi_agesex_df <- rbind(evppi_agesex_df, evppi_agesex_city_df_rearranged) # add to total evppi dataframe
} # end of city loop
# merge with evppi_df data
evppi_df$gender <- 'all'
evppi_df$age <- 'all'
evppi_df$age_gender <- 'all'
evppi_agesex_df <- rbind(evppi_agesex_df,evppi_df)
# change order of columns such that ordered by scenario and demographic group
evppi_agesex_df <- evppi_agesex_df %>% relocate(city,parameters, age, gender, age_gender)
# re-order rows
evppi_agesex_df <- evppi_agesex_df[order(evppi_agesex_df$city, evppi_agesex_df$age_gender),]
saveRDS(evppi_agesex_df,'results/multi_city/evppi_agesex.Rds',version=2)
evppi_agesex_csv <- paste0('results/multi_city/evppi_agesex_',output_version,".csv")
#write.csv(evppi_df,'results/multi_city/evppi.csv',row.names = FALSE) # save as csv file
write.csv(evppi_agesex_df,evppi_agesex_csv,row.names = FALSE) # save as csv file
# create output plots
output_pdf <- paste0('results/multi_city/evppi_agesex_',output_version,".pdf")
#{pdf('results/multi_city/evppi.pdf',height=15,width=4+length(outcome_voi_list))
{pdf(output_pdf,height=15,width=4+length(age_gender_cat)+1)
for ( city_name in cities){
evppi_agesex_city_df <- get(paste0("evppi_agesex_",city_name,'_df'))
if (voi_add_sum){outcome_list <- c(outcome_voi_list, 'sum')
}else{ outcome_list <- outcome_voi_list}
# loop through each outcome in outcome_voi_list separately and create one page per outcome and city