Query for druggable 2nd order interactors

queries/sparql/query-04-druggable-sars-cov-2-interactors_2nd_order.yaml

@@ -0,0 +1,28 @@
+title:
+  "Get druggable 2nd order interactors"
+description:
+  "Get druggable (Tclind) human proteins that interact human proteins that interact with SARS-CoV-2 proteins, along with the relevant drugs"
+endpoint:
+  "http://kg-hub-rdf.berkeleybop.io/blazegraph/sparql"
+query: >
+  PREFIX xsd: <http://www.w3.org/2001/XMLSchema#>
+  prefix owl: <http://www.w3.org/2002/07/owl#>
+  prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#>
+  prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#>
+  prefix bl: <https://w3id.org/biolink/vocab/>
+  SELECT ?covp ?covplab ?humanp ?humanplab ?humanp2 ?humanp2lab ?drug ?druglab
+  WHERE {
+    VALUES ?covtaxon {"2697049"^^xsd:string }
+    VALUES ?humantaxon { "9606"^^xsd:string }
+  ?humanp bl:interacts_with ?covp .
+  ?humanp bl:interacts_with ?humanp2 .
+  ?covp bl:category bl:Protein; <https://www.example.org/UNKNOWN/ncbi_taxid> ?covtaxon .
+  ?humanp bl:category bl:Protein; <https://www.example.org/UNKNOWN/ncbi_taxid> ?humantaxon .
+  ?humanp2 bl:category bl:Protein; <https://www.example.org/UNKNOWN/ncbi_taxid> ?humantaxon .
+  ?humanp2 <https://www.example.org/UNKNOWN/TDL> "Tclin"^^<http://www.w3.org/2001/XMLSchema#string> .
+  ?drug bl:category bl:Drug; bl:interacts_with ?humanp2 .
+  OPTIONAL { ?covp rdfs:label ?covplab } .
+  OPTIONAL { ?humanp rdfs:label ?humanplab } .
+  OPTIONAL { ?humanp2 rdfs:label ?humanp2lab } .
+  OPTIONAL { ?drug rdfs:label ?druglab } .
+  }