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text mining bug? Imatinib Treats Coronary Artery Disorder #334
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I tried to rerun the query https://ui.test.transltr.io/results?l=Coronary%20Artery%20Disorder&t=0&q=8a4ab001-3e8e-4690-92a3-539c9c1dc0bc but unfortunately imatinib no longer shows up in the results. However, it looks like this record from text mining provider is the one that came through previously https://biothings.ncats.io/text_mining_targeted_association/association/caac13f5f0d9dd679cf2e30e8304350ea0774981ec1775f74cd1503bca2e3853-treats. assigning to @bill-baumgartner... |
@gglusman please retest |
My vote would be to leave open for now as TMKP has not addressed the issue yet. |
I retested and have a couple of novel observations. When asking what drugs may treat Heart Disorder, imatinib is not among the answers. => https://ui.ci.transltr.io/results?l=Heart%20Disorder&i=MONDO:0005267&t=0&q=1ee0b9e4-f5ee-47e2-b446-af5bf94cbf8f When asking what drugs may treat Coronary Artery Disorder (CAD), imatinib is listed among the 1132 results, with a score of 87.0 this time. Last time it had a score of 0.8 ! The new problem I see is that the other three publications don't talk about CAD at all... but they cite Nozawa 2014. The title of Nozawa 2014 in the References section is the only place where CAD is mentioned. |
This answer of But what I find curious about this case is that the cited evidence in the Translator UI, the ARAX UI and the robokop doesn't seem to match what's returned by the TMKP API. That's illustrated in the screenshot below, which are snippets from these API calls:
I don't think the original TMKP pubs are any better at supporting the assertion that imatinib treats CAD, but I'm pointing this out just so the ROBOKOB team can make sure that the provenance is being handled as intended. (Also, I think ROBOKOP is using |
@EvanDietzMorris is this a known issue that you are working on? |
Yes, we do have the wrong infores for tmkp edges in the robokop graph at
the moment but it will be fixed in the next graph very soon.
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@EvanDietzMorris I think that this is a different issue. Take a look at Andrew's comment above. Is this because we maybe have an old pull of TMPK? |
At any rate, I don't think that this is an "opposite of what I asked for", so I'm removing the label |
Re-tested on CI August 12. The evidence for the direct path is just a link to BTE. Evidence supporting 'imatinib treats heart failure' is one publication without displayed information: |
"Given the optimal response to imatinib treatment with a stable course of disease and the patient's good general state of health despite significant comorbidities such as arterial hypertension, insulin‐dependent diabetes mellitus, coronary artery disease, asymptomatic peripheral arterial disease, and cerebrovascular disease with a history of stroke, the patient was considered eligible for retransplantation"
In other words, CAD is mentioned as one comorbidity of that patient, and there's no indication that imatinib treats CAD.
Moreover, imatinib is considered potentially cardiotoxic.
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