DiscoverySystemSimulator

Introduction

DiscoverySystemSimulator is an R package that simulates effect discovery in an active surveillance system.

Features

Simulates:

• Multiple databases
• Multiple exposure-outcome pairs
• Multiple methods (simulated by resampling the comparator, reflecting different ways to construct the counterfactual), each with different systematic error distributions
• Multiple times at risk
• Multiple looks over time

For each estimate, this is computed:

• Patient time in target and comparator (during time at risk)
• Outcomes observed in target and comparator (during time at risk)
• Estimated effect size, confidence interval, p-value, log likelihood ratio, and likelihood profile (Poisson regression)

Technology

DiscoverySystemSimulator is an R package.

System Requirements

Requires R (version 4.0.0 or higher). Installation on Windows requires RTools. Libraries used in DiscoverySystemSimulator require Java.

Installation

1. See the instructions here for configuring your R environment, including RTools and Java.

2. In R, use the following commands to download and install CohortMethod:

install.packages("remotes")
remotes::install_github("schuemie/DiscoverySystemSimulator")

User Documentation

• Package manual: DiscoverySystemSimulator.pdf

Support

• Developer questions/comments/feedback: OHDSI Forum
• We use the GitHub issue tracker for all bugs/issues/enhancements

Contributing

Read here how you can contribute to this package.

License

CohortMethod is licensed under Apache License 2.0

Development

DiscoverySystemSimulator is being developed in R Studio.

Development status

DiscoverySystemSimulator is under development. Do not use.