You signed in with another tab or window. Reload to refresh your session.You signed out in another tab or window. Reload to refresh your session.You switched accounts on another tab or window. Reload to refresh your session.Dismiss alert
Currently the Hill equation is written in PK-Sim in the following way (e.g. a cellular process):
R ~ K_water_cell * C_cell^alpha / (Km^alpha + K_water_cell * C_cell^alpha)
Since K_water_cell * C_cell is the free drug concentration, I would think the equation should read as follows:
R ~ (K_water_cell * C_cell)^alpha / (Km^alpha + (K_water_cell * C_cell)^alpha)
This applies for all metabolization and transport rate equations and analogously to the equations "BrainPgPToPlasma_Hill" and "BrainActiveInfluxFromPlasma_Hill" with fu instead of K_water_cell.
The text was updated successfully, but these errors were encountered:
Currently the Hill equation is written in PK-Sim in the following way (e.g. a cellular process):
R ~ K_water_cell * C_cell^alpha / (Km^alpha + K_water_cell * C_cell^alpha)
Since K_water_cell * C_cell is the free drug concentration, I would think the equation should read as follows:
R ~ (K_water_cell * C_cell)^alpha / (Km^alpha + (K_water_cell * C_cell)^alpha)
This applies for all metabolization and transport rate equations and analogously to the equations "BrainPgPToPlasma_Hill" and "BrainActiveInfluxFromPlasma_Hill" with fu instead of K_water_cell.
The text was updated successfully, but these errors were encountered: