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Unit of t1/2 in individual enzyme expression is not updated when changing unit in Expression profile #2847

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TWendl opened this issue Dec 6, 2023 · 7 comments · Fixed by #2852
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hotfix To be implemented in hotfix prio: high type: bug
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@TWendl
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TWendl commented Dec 6, 2023

Steps to reproduce:
Individual was loaded from template and opened. CYP3A4 expression profile was opened and value and unit of t1/2 were changed.
-->value was updated in individual, but not unit!

@Yuri05
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Yuri05 commented Dec 14, 2023

I can confirm that it's not just a refresh problem.
When using the individual in a simulation - the simulation results are wrong.
Removing the expression profile from the individual and adding it again, fixes the problem

The problem still exists in V12. It seems that only t1/2 (intestine) is affected, not other parameters.
E.g. before the change:

After the change:

@msevestre FYI

@msevestre msevestre self-assigned this Dec 18, 2023
@msevestre
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I can reproduce with all paramters

@msevestre
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@msevestre
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adding and removing updates
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@msevestre
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updating UNIT first and then value also works

@msevestre
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@msevestre
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I think the sync is not triggered for unit change that's all

msevestre added a commit that referenced this issue Dec 19, 2023
@msevestre msevestre mentioned this issue Dec 19, 2023
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rwmcintosh pushed a commit that referenced this issue Dec 19, 2023
@rwmcintosh rwmcintosh added the hotfix To be implemented in hotfix label Feb 28, 2024
rwmcintosh added a commit that referenced this issue Feb 28, 2024
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Labels
hotfix To be implemented in hotfix prio: high type: bug
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4 participants