Probenecid-Furosemide-DDI

Modeling of published clinical Probenecid-Furosemide-DDI studies for model evaluation

Repository files

Within this repository, we share a PK-Sim project file containing simulations of all published clinical studies used to evaluate the predictive performance of our models regarding the Probenecid-Furosemide-DDI, including the respective observed data. For further details and documentation please refer to [1].

Version information

PK-Sim Version 9.0.

Code of conduct

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Contribution

We encourage contribution to the Open Systems Pharmacology community. Before getting started please read the contribution guidelines. If you are contributing code, please be familiar with the coding standard.

License

The model is distributed under the GPLv2 License.

Reference

[1] Britz H, Hanke N, Taub ME, Wang T, Prasad B, Fernandez É, Stopfer P, Nock V, Lehr T. Physiologically Based Pharmacokinetic Models of Probenecid and Furosemide to Predict Transporter Mediated Drug-Drug Interactions. Pharm Res. 2020 Nov 25;37(12):250