MMV670652 was a promising candidate from the briefing document (/data/7353.html) and should be resynthesised and the enantiomers separated by prep HPLC. Will need to find a collaborator to assist with separation.
The briefing document seems unclear - it reads like they currently have one enantiomer and think the other one might be better? Or was it screened as a racemate? I could potentially have one of my students take this as a project (one's on amide linkers, the other on alcohol linkers).
For clarification - MMV670652 was tested as a racemate. It would be beneficial to find a collaborator to separate the enantiomers in order to understand the activity and stability of each enantiomer. Is someone responsible for reaching out to these contacts listed by Mat and inquiring about willingness to help?
I'll ask around my university about this, or in-case I need to do any separation in future.
Closing before March 2014 meeting (http://malaria.ourexperiment.org/osddmalaria_meeting_/9470) owing to shift in focus away from MMV670652 towards synthetically more tractable MMV669844