1) Complete synthesis of racemic MMV670652 through solving difluoromethylation step.

[alintheopen]

MMV670652 was a promising active compound from the CRO data set. Resynthesis is necessary to confirm potency and to subsequently separate and evaluate the biological activities of each enantiomer.

The trickiest step in the synthesis seems to be the difluoromethylation. The CRO synthesis used Freon to alkylate the alcohol but this is not possible as Freon-22 can't be used in Australia.

First steps in solving this challenge is to post an appeal for help from community on difluoromethylation, along with full context: what we know of the literature and the links to the attempts described in the ELN.

[alintheopen]

Blog post appeal is here: http://malaria.ourexperiment.org/uri/49b

[mattodd]

Closing - see comments on #111