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Following discussion (Issue #232) a selection of target compounds for the second round of biological evaluation for the triazolopyrazines.
This compound is a representative example from the chiral ethers that could be resolved by preparative HPLC at a later stage in the project. It also meets 3 of the 4 ESAC criteria:
Aim for log P between 1.5 and 3.5
Revisit other cores with good metabolic profiles, e.g. MMV669846
Use more sp3 carbons, and de-planarize through chirality at C-5 or in substitutions at C-2 or C-5
Following discussion (Issue #232) a selection of target compounds for the second round of biological evaluation for the triazolopyrazines.
This compound is a representative example from the chiral ethers that could be resolved by preparative HPLC at a later stage in the project. It also meets 3 of the 4 ESAC criteria:
ELN Links: AEW 173-1 (http://malaria.ourexperiment.org/uri/67c)
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