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PMID:30727143 Baseline Sensitivity of Monilinia fructicola from China to the DMI Fungicide SYP-Z048 and Analysis of DMI-Resistant Mutants #206
Comments
Hi @CuzickA, the paper doesn't allow editing unfortunately. |
Hi @jingluodatacurator, I'm looking to see if there is an alternative name for 'SYP-Z048 (5-(4-chlorophenyl)-2,3-di-methyl-3-(pyridine-3)-oxazoline) ' It looks like 'pyrisoxazole' could be a synonym Do you agree that this chemical is 'pyrisoxazole'? (Note: pyrisoxazole is on the FRAC list and already added to our anti-infective list). |
Mutant generation by UV irradiation. It is not clear to me from the paper which parental strains generated which UV mutants. I think we will have to choose a representative wild type S strain and a R mutant. Several S and R strains had Y136F respectively so hopefully this will rule out complications of any other UV mutations in the background outside of the Cyp51 target. |
I think we need to change the strain here to 'MPA18 ' to represent the S wildtype isolate in Table 4. For some reason strain 'MBJA8' is not mentioned in Table 4, just in earlier Tables. @jingluodatacurator, please could you read my comments above and see if you agree. If you do, please could you add the strain 'MPA18' instead of 'MBJA8' |
Next steps
Then session will be ready for approval. |
@CuzickA, yes it looks correct to me. |
Hi @jingluodatacurator, I have just noticed that the PMID and title entered here for curation does not match the title of the paper that we are curating. I have just looked up the correct PMID for this article and it is PMID: 30727143 not PMID:30717143. Please could you start a new curation session with the correct PMID and enter the curated information. Unfortunately there is no shortcut for this but at least there is only one annotation :-). (Once this is done, I will then ask James to delete the incorrect PMID:30717143 session from PHI-Canto.) Here is the UniProt D0VVD6 and if you agree with my comments above you can amend the strain in the genotype from 'MBJA8' to 'MPA18'. |
Hi @CuzickA, thanks so much for spotting the mistake (I was wondering why I couldn't find the curation session in my curation list). |
Hi @CuzickA, I have created the new session with annotations, please check. |
Hi @jingluodatacurator, thank you for doing this. I have just made a couple of changes to match the original entry. |
Next steps
Then session will be ready for approval.
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Hi @jseager7, please could you delete this incorrectly added PMID/session from PHI-Canto?
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Sure, I'll try to get this done this week. |
PMID:30717143 and its curation session (374b149aa1776aac) have been removed from PHI-Canto now. |
AE alteration in archetype checked by Nichola and looks fine. Approving session and closing ticket. |
Curated by @jingluodatacurator
https://canto.phi-base.org/curs/374b149aa1776aac (this session will need to be deleted)
Link with correct PMID https://canto.phi-base.org/curs/93b1e80c305cc8da
Uniprot No.:D0VVD6
Strains: MBJA8, MSB11, MPA18
Main expt. for curation: see in Materials and Methods 'Generation of SYP-Z048-resistant mutants' section.
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