Code for filtering UK biobank data for heart failure phenotypes.
bb <- fread("filename.tab", header=TRUE, sep="\t", fill=TRUE)
Change <filename> to the .tab UKBB data file.
Patient self- reported non-cancer diagnosis (datafield 20002) and operations (datafield 2004) at initial nurse-led interview.
Primary (datafield 40001) and contributory/secondary (datafield 40002) causes of death.
Primary (ICD-10 - datafield 41202; ICD-9 - datafield 41203) and secondary (ICD-10 41204; ICD-9 datafield 41205) diagnosis codes recorded during all hospital admission episodes.
Patient self-reported previous vascular problems diagnosed by a doctor (datafield 6150).
All cause heart failure
Any heart failure (as defined below) excluding individuals with HCM (ICD10 codes I42.1 and I42.2, and self reported HCM at nurse interview).
Non-ischaemic cardiomyopathy (or heart failure without known coronary artery disease)
Any heart failure (as defined below) excluding individuals with HCM (ICD10 codes I42.1 and I42.2, and self reported HCM at nurse interview) and coronary artery disease (defined below).
Non-ischaemic cardiomyopathy (SZ definition)
Non-ischaemic cardiomyopathy (as defined below) excluding individuals with HCM (ICD10 codes I42.1 and I42.2, and self reported HCM at nurse interview) and coronary artery disease (defined below).
Non-ischaemic cardiomyopathy (Aragam definition)
Hospitalisation or death due to the following codes: ICD-10: I42.0 (dilated cardiomyopathy) and I50.1 (left ventricular failure), ICD-9: left heart failure (4281); excluding individuals with HCM (ICD10 codes I42.1 and I42.2, and self reported HCM at nurse interview) and coronary artery disease (defined below).
Coronary artery disease
Coronary artery disease (as defined below).
ICD-10 (40001, 400002, 41202, 41204)
I11.0 (I110) – Hypertensive heart disease with HF
I13.0 (I130) – Hypertensive heart and renal disease with HF
I13.2 (I132) - Hypertensive heart and renal disease with HF and renal failure
I25.5 (I255) – Ischaemic CM
I42.0 (I420) – dilated CM
I42.5 (I425) – restrictive CM
I42.8 (I428) – other CM
I42.9 (I429) – CM, unspecified
I50.0 (I500) – congestive HF
I50.1 (I501) – left ventricular failure
I50.9 (I509) – HF, unspecified
ICD-9 (41203, 41205)
428 – HF
425 – CM
4254 – other primary CM
4280 – congestive HF
4281 – left HF
4289 – HF unspecified
Self-reported (20002)
1076 – HF/pulmonary oedema
1079 - CM
ICD-10 (40001, 400002, 41202, 41204)
I42.0 (I420) – dilated CM
I50.0 (I500) – congestive HF
I50.1 (I501) – left ventricular failure
I50.9 (I509) – HF, unspecified
ICD-9 (41203, 41205)
428 – HF
425 – CM
4254 – other primary CM
4280 – congestive HF
4281 – left HF
4289 – HF unspecified
Self-reported (20002)
1076 – HF/pulmonary oedema
1079 - CM
ICD-10 (40001, 400002, 41202, 41204)
I21.0 (I210) – acute anterior MI
I21.1 (I211) – acute inferior MI
I21.2 (I212) – acute other site MI
I21.3 (I213) – acute unspecified site MI
I21.4 (I214) – acute subendocardial MI
I21.9 (I219) – acute MI unspecified
I22 (I22) – subsequent MI
I22.0 (I220) – subsequent anterior mI
I22.1 (I221) – subsequent inferior MI
I22.8 (I228) – subsequent other site MI
I22.9 (I229) – subsequent unspecified site MI
I25.2 – old MI
ICD-9 (41203, 41205)
410
411
412
Self-reported (20002, 20004)
1075 - MI
1095 – CABG
1523 – Triple heart bypass
1070 – Coronary angioplasty +/- stenting
Vascular problems diagnosed by dr (6150)
1 – heart attack